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Pishdad, Parisa, Zeinali-Rafsanjani, Banafsheh, Poursadeghfard, Maryam, Kalaee, Mahsa, Ostovarfar, Jeyran, Salehi, Alireza. (1404). Investigating Depression and MRI Associations in Middle Eastern Relapsing-Remitting Multiple Sclerosis. سامانه مدیریت نشریات علمی, (), -.
Parisa Pishdad; Banafsheh Zeinali-Rafsanjani; Maryam Poursadeghfard; Mahsa Kalaee; Jeyran Ostovarfar; Alireza Salehi. "Investigating Depression and MRI Associations in Middle Eastern Relapsing-Remitting Multiple Sclerosis". سامانه مدیریت نشریات علمی, , , 1404, -.
Pishdad, Parisa, Zeinali-Rafsanjani, Banafsheh, Poursadeghfard, Maryam, Kalaee, Mahsa, Ostovarfar, Jeyran, Salehi, Alireza. (1404). 'Investigating Depression and MRI Associations in Middle Eastern Relapsing-Remitting Multiple Sclerosis', سامانه مدیریت نشریات علمی, (), pp. -.
Pishdad, Parisa, Zeinali-Rafsanjani, Banafsheh, Poursadeghfard, Maryam, Kalaee, Mahsa, Ostovarfar, Jeyran, Salehi, Alireza. Investigating Depression and MRI Associations in Middle Eastern Relapsing-Remitting Multiple Sclerosis. سامانه مدیریت نشریات علمی, 1404; (): -.

Investigating Depression and MRI Associations in Middle Eastern Relapsing-Remitting Multiple Sclerosis

Journal of Biomedical Physics and Engineering
مقالات آماده انتشار، اصلاح شده برای چاپ، انتشار آنلاین از تاریخ 30 شهریور 1404    اصل مقاله (946.24 K)
نوع مقاله: Original Research
نویسندگان
Parisa Pishdad1؛ Banafsheh Zeinali-Rafsanjani1؛ Maryam Poursadeghfard2؛ Mahsa Kalaee3؛ Jeyran Ostovarfar4؛ Alireza Salehi* 4
1Medical Imaging Research Center, Department of Radiology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
2Clinical Neurology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
3Department of Neurology, Shiraz University of Medical Science, Shiraz, Iran
4Department of MPH, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
چکیده
Background: Multiple Sclerosis (MS) is often complicated by depression, worsening disability and quality of life. Global depression prevalence in MS is ~27%, but Middle Eastern data are scarce. The neurobiological basis of depression in Relapsing-Remitting Multiple Sclerosis (RRMS) is unclear.
Objective: This study aimed to assess depression prevalence in Middle Eastern RRMS patients versus controls, evaluate disability using the Expanded Disability Status Scale (EDSS), and explore Magnetic Resonance Imaging (MRI) correlations with depressive symptoms.
Material and Methods: In a cross-sectional study (June 2022–June 2023), 105 RRMS patients (mean age 36.2 ±13.9 years, 83.8% female) and 111 controls (mean age 39.1±10.9 years, 74.8% female) were recruited from Shiraz, Iran MS clinics. Depression was measured using the Beck Depression Inventory (BDI), disability via EDSS, and MRI (1.5-Tesla) analyzed for lesion burden and brain volume using VolBrain. Statistical analyses included t-tests, chi-squared tests, and correlations (P-value<0.05).
Results: Depression was more prevalent in RRMS patients (33.3%) than controls (24.5%; P-value=0.15), especially in younger females (P-value=0.02). Mean EDSS was low (1.3–1.4), weakly correlating with right insular cortex plaque volume (r=0.20, P-value=0.03). Depressed patients had higher left limbic (P-value=0.05) and insular cortex (P-value=0.05) plaque burdens, with weak BDI correlations (r=0.19–0.20, P-value<0.04). Brain volume was reduced in depressed patients (P-value=0.09).
Conclusion: Depression affects one-third of Middle Eastern RRMS patients, exceeding controls. Limbic and insular plaque burdens suggest network dysconnectivity drives depressive symptoms. Routine screening and region-specific interventions are needed.
کلیدواژه‌ها
Relapsing-Remitting Multiple Sclerosis؛ Depression؛ Magnetic Resonance Imaging؛ Brain Atrophy؛ Middle East
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