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Simplified Intravoxel Incoherent Motion (IVIM) Imaging for Glioma Grading: A Comparative Analysis of Routine and Three b-Value Approaches | ||
| Journal of Biomedical Physics and Engineering | ||
| مقالات آماده انتشار، اصلاح شده برای چاپ، انتشار آنلاین از تاریخ 30 شهریور 1404 اصل مقاله (1.83 M) | ||
| نوع مقاله: Original Research | ||
| نویسندگان | ||
| Hadi Akbari-Zadeh1؛ Babak r Ganjeifa2؛ Marziyeh Maleki2؛ Sedighe Khoshbash3؛ Behzad Aminzadeh4؛ Pegah Lotfi1؛ Alireza Montazerabadi* 1، 5 | ||
| 1Department of Medical Physics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran | ||
| 2Department of Neurosurgery, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran | ||
| 3Ghaem Educational, Research and Treatment Center, Mashhad, Iran | ||
| 4Department of Radiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran | ||
| 5Medical Physics Research Center, Basic Sciences Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran | ||
| چکیده | ||
| Background: Intravoxel Incoherent Motion (IVIM) imaging shows promise for glioma characterization, but complex acquisition and analysis hinder its clinical use. Simplifying IVIM by using fewer b-values could improve feasibility. This study investigates a simplified three b-value IVIM approach for glioma grading. Objective: To assess the diagnostic performance of a simplified IVIM model using three b-values and to analyze all derived quantitative parameters for glioma grading. Material and Methods: This retrospective study analyzed IVIM data acquired from 30 glioma patients. A simplified model was implemented using b-values of 0, 200, and 1000 s/mm². In addition to routine IVIM parameters (D, f, D*), we calculated simplified parameters: D3b, f3b, D3b*, ADC0-200, ADC0-1000, ADC200-1000, and Simple Perfusion Fraction (SPF) for each region of interest (tumor, edema, and normal-appearing white matter). Correlations were assessed, and diagnostic performance was evaluated. Results: Strong correlations were observed between simplified and routine IVIM parameters. The cancerous region was the optimal Regions of Interest (ROI) for grading. ADC200-1000, and SPF demonstrated superior diagnostic performance (the Area Under the Curve (AUCs) of 85.3% and 77.2%, respectively) compared to routine IVIM parameters. Conclusion: This study demonstrates that a simplified three b-value IVIM approach is clinically feasible for glioma grading. Analyzing all derived parameters shows the potential of this simplified technique to provide valuable diagnostic information, reducing acquisition time and complexity while maintaining accuracy. Furthermore, ADC200-1000 has shown superior performance compared to conventional Apparent Diffusion Coefficient (ADC) ADC0-1000 in Diffusion-Weighted Imaging (DWI) with a more accurate representation of tissue diffusion characteristics, resulting in its replacement for conventional ADC. | ||
| کلیدواژه‌ها | ||
| Glioma؛ Diffusion Magnetic Resonance Imaging؛ Perfusion Imaging؛ Simplified IVIM؛ Three b-value IVIM | ||
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