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Farahmand, Faranak, Rafiee, Azade, Mohammadi, Najmeh. (1405). In vitro Evaluation of the Remineralizing Potential and Color Change of Modified Fluoride Varnish with Polyvinylpyrrolidone-Coated Silver Nanoparticles on Incipient Enamel Lesions in Primary Teeth. سامانه مدیریت نشریات علمی, 27(3), 265-275. doi: 10.30476/dentjods.2025.107027.2711
Faranak Farahmand; Azade Rafiee; Najmeh Mohammadi. "In vitro Evaluation of the Remineralizing Potential and Color Change of Modified Fluoride Varnish with Polyvinylpyrrolidone-Coated Silver Nanoparticles on Incipient Enamel Lesions in Primary Teeth". سامانه مدیریت نشریات علمی, 27, 3, 1405, 265-275. doi: 10.30476/dentjods.2025.107027.2711
Farahmand, Faranak, Rafiee, Azade, Mohammadi, Najmeh. (1405). 'In vitro Evaluation of the Remineralizing Potential and Color Change of Modified Fluoride Varnish with Polyvinylpyrrolidone-Coated Silver Nanoparticles on Incipient Enamel Lesions in Primary Teeth', سامانه مدیریت نشریات علمی, 27(3), pp. 265-275. doi: 10.30476/dentjods.2025.107027.2711
Farahmand, Faranak, Rafiee, Azade, Mohammadi, Najmeh. In vitro Evaluation of the Remineralizing Potential and Color Change of Modified Fluoride Varnish with Polyvinylpyrrolidone-Coated Silver Nanoparticles on Incipient Enamel Lesions in Primary Teeth. سامانه مدیریت نشریات علمی, 1405; 27(3): 265-275. doi: 10.30476/dentjods.2025.107027.2711

In vitro Evaluation of the Remineralizing Potential and Color Change of Modified Fluoride Varnish with Polyvinylpyrrolidone-Coated Silver Nanoparticles on Incipient Enamel Lesions in Primary Teeth

Journal of Dentistry
مقاله 9، دوره 27، شماره 3 - شماره پیاپی 92، آذر 2026، صفحه 265-275    اصل مقاله (779.46 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.30476/dentjods.2025.107027.2711
نویسندگان
Faranak Farahmand1؛ Azade Rafiee* 2؛ Najmeh Mohammadi3
1Student Research Committee, Dept. of Pediatric Dentistry, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.
2Postgraduate Student of Research Committee, Dept. of Pediatric Dentistry, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.
3Pediatric Dentist, Private Practice, Shiraz, Iran.
چکیده
Background: Dental caries is closely associated with biofilms and characterized by cycles of demineralization and remineralization that weaken tooth structure over time. Given the need for effective prevention and enhanced remineralization, developing a more esthetic and efficient approach is essential in improving oral health outcomes.
Purpose: The present study aimed to assess the remineralizing potential and color change of modified fluoride varnish with polyvinylpyrrolidone-coated silver nanoparticles (PVP-coated AgNPs) on incipient enamel lesions in primary teeth.
Materials and Method: In this in vitro study, 130 caries-free primary canine teeth underwent caries induction and were randomly assigned to one of three treatments: (1) fluoride varnish (FV), (2) silver diamine fluoride (SDF), and (3) FV with PVP-coated AgNPs. After thermocycling-aging and an eight-day pH cycling regimen, the remineralization effects and color change were evaluated by enamel microhardness (EMH) test and spectrophotometric color assessment. Ten samples were used for surface morphology assessment with field emission scanning electron microscopy and energy-dispersive X-ray spectrometry (FESEM-EDS). One-way ANOVA and Tukey's post-hoc tests were used for data analysis (p Value<0.05).
Results: The highest average±SD recovery of EMH values was found in the SDF group (52.43±2.58), followed by FV with PVP-coated AgNPs group (43.21±1.73), and FV group (35.60±1.36), respectively (all, p< 0.001). The voids on the demineralized enamel surface were partially coated with newly deposited minerals in FESEM images of all groups. SDF Group had the best calcium/ phosphorus ratio among the intervention groups (2.58± 0.001); followed by FV with PVP-coated AgNPs group (1.94±0.001) and FV group (1.91± 0.001), respectively. The color change of enamel samples treated with FV and modified FV with PVP-coated AgNPs was clinically imperceptible (all, ∆E < 3.3), whereas SDF-treated samples caused distinct staining (p< 0.001).
Conclusion: FV with PVP-coated AgNPs effectively remineralizes incipient enamel lesions in primary teeth with minimal color change, offering a promising alternative to SDF.
کلیدواژه‌ها
Silver Compounds؛ Fluorides؛ Nanoparticles؛ Tooth Remineralization؛ Microscopy
مراجع
  • Pitts NB, Zero DT, Marsh PD, Ekstrand K, Weintraub JA, Ramos-Gomez F, et al. Dental caries. Nat Rev Dis Primers. 2017; 3: 17030.
  • Nimbeni SB, Nimbeni BS, Divakar DD. Role of chitosan in remineralization of enamel and dentin: A systematic review. Int J Clin Pediatr Dent. 2021; 14: 562.
  • Dhanapriyanka M, Kosgallana S, Kanthi R, Jayasekara P, Dao TMA, Ha DH, et al. Professionally applied fluorides for preventing and arresting dental caries in low- and middle-income countries: Systematic review. J Public Health Dent. 2024; 84: 213-227.
  • Mohd Said SN, Ekambaram M, Yiu CK. Effect of different fluoride varnishes on remineralization of artificial enamel carious lesions. Int J Paediatr Dent. 2017; 27: 163-173.
  • Chu CH, Mei L, Seneviratne CJ, Lo EC. Effects of silver diamine fluoride on dentine carious lesions induced by Streptococcus mutans and Actinomyces naeslundii biofilms. Int J Paediatr Dent. 2012; 22: 2-10.
  • Rafiee A, Memarpour M, Benam H. Evaluation of bleaching agent effects on color and microhardness change of silver diamine fluoride-treated demineralized primary tooth enamel: An in vitro study. BMC Oral Health. 2022; 22: 347.
  • Horst JA, Ellenikiotis H, Milgrom PL. UCSF Protocol for Caries Arrest Using Silver Diamine Fluoride: Rationale, Indications and Consent. J Calif Dent Assoc. 2016; 44: 16-28.
  • Freire PL, Stamford TC, Albuquerque AJ, Sampaio FC, Cavalcante HM, Macedo RO, et al. Action of silver nanoparticles towards biological systems: cytotoxicity evaluation using hen's egg test and inhibition of Streptococcus mutans biofilm formation. Int J Antimicrob Agents. 2015; 45: 183-187.
  • Javed R, Zia M, Naz S, Aisida SO, Ain Nu, Ao Q. Role of capping agents in the application of nanoparticles in biomedicine and environmental remediation: recent trends and future prospects. J Nanobiotechnol. 2020; 18: 172.
  • Yin IX, Zhao IS, Mei ML, Li Q, Yu OY, Chu CH. Use of silver nanomaterials for caries prevention: a concise review. Int J Nanomed. 2020: 3181-3191.
  • Zein R, Alghoraibi I, Soukkarieh C, Ismail M, Alahmad A. Influence of Polyvinylpyrrolidone Concentration on Properties and Anti-Bacterial Activity of Green Synthesized Silver Nanoparticles. Micromachines. 2022; 13: 777.
  • Butrón Téllez Girón C, Mariel J, Pierdant M, Hernández-Sierra J, Morales-Sánchez JE, Ruiz F. Effectiveness of a combined silver nanoparticles/fluoride varnish in dental remineralization in children: in vivo study. Superficies y Vacio. 2017; 30: 21-24.
  • Ali A, Ismail H, Amin K. Effect of nanosilver mouthwash on prevention of white spot lesions in patients undergoing fixed orthodontic treatment- a randomized double-blind clinical trial. J Dent Sci. 2022; 17: 249-255.
  • Atteya SM, Amer HA, Saleh SM, Safwat Y. Self-assembling peptide and nano-silver fluoride in remineralizing early enamel carious lesions: randomized controlled clinical trial. BMC Oral Health. 2023; 23: 577.
  • Nozari A, Ajami S, Rafiei A, Niazi E. Impact of nano hydroxyapatite, nano silver fluoride and sodium fluoride varnish on primary teeth enamel remineralization: an in vitro study. J Clin Diagn Res. 2017; 11: ZC97.
  • Akyildiz M, Sönmez IS. Comparison of Remineralising Potential of Nano Silver Fluoride, Silver Diamine Fluoride and Sodium Fluoride Varnish on Artificial Caries: An in vitro Study. Oral health Prev Dent. 2019; 17: 469-477.
  • Arnaud M, Junior PC, Lima MG, e*Silva AV, Araujo JT, Gallembeck A, et al. Nano-silver fluoride at Higher Concentration for Caries Arrest in primary molars: a Randomized Controlled Trial. Int J Clin Pediatr Dent. 2021; 14: 207.
  • El-Desouky DI, Hanno*A, Elhamouly Y, Hamza SA, El-Desouky LM, Dowidar KM. Preventive potential of nano silver fluoride versus sodium fluoride varnish on enamel caries like lesions in primary teeth: in vitro study. BMC Oral Health. 2022; 22: 244.
  • Favaro JC, Detomini TR, Maia LP, Poli RC, Guiraldo RD, Lopes MB, et al. Anticaries agent based on silver nanoparticles and fluoride: characterization and biological and remineralizing effects: An in vitro study. Int J Dent. 2022; 2022: 9483589.
  • Rafiee A, Memarpour M, Amiri M, Azadi A, Fekri N, Mozafari N, et al. Comparison of various chitosan-based in situ forming gels with sodium fluoride varnish for enamel biomineralization: an in vitro pH cycling model. Sci Rep. 2024; 14: 21100.
  • Haghgoo R, Saderi H, Eskandari M, Haghshenas H, Rezvani M. Evaluation of the antimicrobial effect of conventional and nanosilver-containing varnishes on oral streptococci. J Dent. 2014; 15: 57.
  • Price RB, Sullivan B. Effect of Indenter Load on Vickers Microhardness and Indentation Depth of One Resin Composite. Materials. 2024; 17: 6156.
  • Espíndola-Castro L, Rosenblatt A, Galembeck A, Monteiro G. Dentin staining caused by nano-silver fluoride: a comparative study. Oper Dent. 2020; 45: 435-441.
  • Saikaew P, Katekovit K, Buranarachada A, Saimala N, Prayongrat A, Fuangtharnthip P. Effects of NaF versus SDF treatment on microhardness of artificial radiation caries at cervical and root areas. Dent Mater J. 2024; 43: 591-596.
  • Mei ML, Nudelman F, Marzec B, Walker J, Lo E, Walls A, et al. Formation of fluorohydroxyapatite with silver diamine fluoride. J Dent Res. 2017; 96: 1122-1128.
  • Dos*Santos*Jr VE, Vasconcelos*Filho A, Targino AGR, Flores MAP, Galembeck A, Caldas*Jr AF, et al. A new “silver-bullet” to treat caries in children–nano silver fluoride: a randomised clinical trial. J Dent. 2014; 42: 945-951.
  • Freire PL, Albuquerque AJ, Farias IA, da*Silva TG, Aguiar JS, Galembeck A, et al. Antimicrobial and cytotoxicity evaluation of colloidal chitosan–silver nanoparticles–fluoride nanocomposites. Int J Biol Macromol. 2016; 93: 896-903.
  • Poorni S, Kumar RA, Shankar P, Indira R, Ramachandran S. Effect of 10% sodium ascorbate on the calcium: Phosphorus ratio of enamel bleached with 35% hydrogen peroxide: an in vitro quantitative energy-dispersive X-ray analysis. Contemp Clin Dent. 2010; 1: 223-226.
  • Sakr AH, Nassif MS, El-Korashy DI. Amelogenin-inspired peptide, calcium phosphate solution, fluoride and their synergistic effect on enamel biomimetic remineralization: an in vitro pH-cycling model. BMC Oral Health. 2024; 24: 279.
  • Brandt J, Nelson S, Lauer HC, von Hehn U, Brandt S. In vivo study for tooth colour determination-visual versus digital. Clin Oral Investig. 2017; 21: 2863-2871.
  • Ghani S, Hussain T, Bajwa S, Ijaz F, Khan MA, Babar B, et al. Role of Silver Ions in Preventing Demineralisation of Human Enamel. Pak J Med Health Sci. 2022; 16: 163-166.
  • Sayed M, Hiraishi N, Matin K, Abdou A, Burrow MF, Tagami J. Effect of silver-containing agents on the ultra-structural morphology of dentinal collagen. Dent Mater. 2020; 36: 936-944.
  • Albahoth AS, Jeon MJ, Park JW. Synergistic effect of nanosilver fluoride with L-arginine on remineralization of early carious lesions. Scientific Reports. 2025; 15: 5993.
  • Young DA, Quock RL, Horst J, Kaur R, MacLean JK, Frachella JC, et al. Clinical Instructions for Using Silver Diamine Fluoride (SDF) in Dental Caries Management. Compend Contin Educ Dent. 2021; 42: e5-e9.
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