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Gholipour, Farshad, Bahrami Samani, Hossein, Assadi, Alireza, Behnamfar, Amir, Nazarpour, Mohammadjavad, Saberi, Narjes. (1404). Prophylactic Intravenous Furosemide for Reducing Hyponatremia Risk in Monopolar Transurethral Prostate Surgery: A Randomized Clinical Trial. سامانه مدیریت نشریات علمی, 50(10), 698-706. doi: 10.30476/ijms.2025.105024.3860
Farshad Gholipour; Hossein Bahrami Samani; Alireza Assadi; Amir Behnamfar; Mohammadjavad Nazarpour; Narjes Saberi. "Prophylactic Intravenous Furosemide for Reducing Hyponatremia Risk in Monopolar Transurethral Prostate Surgery: A Randomized Clinical Trial". سامانه مدیریت نشریات علمی, 50, 10, 1404, 698-706. doi: 10.30476/ijms.2025.105024.3860
Gholipour, Farshad, Bahrami Samani, Hossein, Assadi, Alireza, Behnamfar, Amir, Nazarpour, Mohammadjavad, Saberi, Narjes. (1404). 'Prophylactic Intravenous Furosemide for Reducing Hyponatremia Risk in Monopolar Transurethral Prostate Surgery: A Randomized Clinical Trial', سامانه مدیریت نشریات علمی, 50(10), pp. 698-706. doi: 10.30476/ijms.2025.105024.3860
Gholipour, Farshad, Bahrami Samani, Hossein, Assadi, Alireza, Behnamfar, Amir, Nazarpour, Mohammadjavad, Saberi, Narjes. Prophylactic Intravenous Furosemide for Reducing Hyponatremia Risk in Monopolar Transurethral Prostate Surgery: A Randomized Clinical Trial. سامانه مدیریت نشریات علمی, 1404; 50(10): 698-706. doi: 10.30476/ijms.2025.105024.3860

Prophylactic Intravenous Furosemide for Reducing Hyponatremia Risk in Monopolar Transurethral Prostate Surgery: A Randomized Clinical Trial

Iranian Journal of Medical Sciences
مقاله 5، دوره 50، شماره 10، دی 2025، صفحه 698-706    اصل مقاله (441.7 K)
نوع مقاله: Original Article(s)
شناسه دیجیتال (DOI): 10.30476/ijms.2025.105024.3860
نویسندگان
Farshad Gholipour1؛ Hossein Bahrami Samani* 1؛ Alireza Assadi2؛ Amir Behnamfar1؛ Mohammadjavad Nazarpour1؛ Narjes Saberi1
1Department of Urology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
2School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
چکیده
Background: Transurethral resection of the prostate (TURP) is the gold standard surgical treatment for benign prostatic hyperplasia (BPH). Despite its widespread use, monopolar TURP carries a risk of significant complications, particularly transurethral resection (TUR) syndrome leading to hyponatremia and fluid overload. The study evaluates whether prophylactic furosemide prevents hyponatremia and TUR syndrome in monopolar TURP.
Methods: This study was a triple-blind randomized clinical trial conducted in Al-Zahra and Khorshid educational hospitals of Isfahan, Iran, in 2022-2023. Patients undergoing monopolar TURP, were divided into two groups: those receiving preoperative furosemide and a control group. The primary outcomes were changes in serum sodium levels and the incidence of hyponatremia. Secondary outcomes included fluid balance, complication rates, and recovery times. Continuous data were analyzed using t test/Mann-Whitney U, categorical data with Fisher’s exact test, and time-based changes with repeated measures ANOVA. Normality was checked via Kolmogorov-Smirnov, and power analysis determined sample size.
Results: The furosemide group demonstrated a significantly lower incidence of hyponatremia than the control group (P=0.008). Additionally, serum sodium levels were significantly higher in the furosemide group after surgery (P=0.011), while potassium levels were lower (P=0.003). Mild hypokalemia was observed as a manageable side effect, primarily in patients with baseline potassium levels below 4.1 mmol/L.
Conclusion: Preoperative administration of furosemide effectively reduces the risk of TUR syndrome during monopolar TURP. Furosemide effectively reduces hyponatremia but may increase hypokalemia in some cases, limiting its clinical utility during monopolar TURP. Patient-specific assessment and further research are needed to ensure its safe and effective use.
Trial registration number: IRCT20211208053328N2.

تازه های تحقیق

Farshad Gholipour (Google Scholar)

Hossein Bahrami Samani (Google Scholar)

کلیدواژه‌ها
Transurethral resection of prostate؛ Hyponatremia؛ Furosemide؛ Water-electrolyte imbalance؛ Postoperative complications
مراجع
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