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Tamadon, Amin, Zare, Afshin, Mahdipour, Mahdi, Salehpour, Aria, Mussin, Nadiar M., Mussina, Aliya A., Aringazina, Raisa A., Duisenova, Ainash, Zhilisbayeva, Kulyash R., Kurmanalina, Madina A., Fu, Chong. (1404). From Mice to Primates: Assessing Hormone-Based Endometriosis Models for Preclinical and Therapeutic Insights. سامانه مدیریت نشریات علمی, (), -. doi: 10.30476/ijms.2025.105805.3975
Amin Tamadon; Afshin Zare; Mahdi Mahdipour; Aria Salehpour; Nadiar M. Mussin; Aliya A. Mussina; Raisa A. Aringazina; Ainash Duisenova; Kulyash R. Zhilisbayeva; Madina A. Kurmanalina; Chong Fu. "From Mice to Primates: Assessing Hormone-Based Endometriosis Models for Preclinical and Therapeutic Insights". سامانه مدیریت نشریات علمی, , , 1404, -. doi: 10.30476/ijms.2025.105805.3975
Tamadon, Amin, Zare, Afshin, Mahdipour, Mahdi, Salehpour, Aria, Mussin, Nadiar M., Mussina, Aliya A., Aringazina, Raisa A., Duisenova, Ainash, Zhilisbayeva, Kulyash R., Kurmanalina, Madina A., Fu, Chong. (1404). 'From Mice to Primates: Assessing Hormone-Based Endometriosis Models for Preclinical and Therapeutic Insights', سامانه مدیریت نشریات علمی, (), pp. -. doi: 10.30476/ijms.2025.105805.3975
Tamadon, Amin, Zare, Afshin, Mahdipour, Mahdi, Salehpour, Aria, Mussin, Nadiar M., Mussina, Aliya A., Aringazina, Raisa A., Duisenova, Ainash, Zhilisbayeva, Kulyash R., Kurmanalina, Madina A., Fu, Chong. From Mice to Primates: Assessing Hormone-Based Endometriosis Models for Preclinical and Therapeutic Insights. سامانه مدیریت نشریات علمی, 1404; (): -. doi: 10.30476/ijms.2025.105805.3975

From Mice to Primates: Assessing Hormone-Based Endometriosis Models for Preclinical and Therapeutic Insights

Iranian Journal of Medical Sciences
مقالات آماده انتشار، اصلاح شده برای چاپ، انتشار آنلاین از تاریخ 23 شهریور 1404    اصل مقاله (1.55 M)
نوع مقاله: Review Article
شناسه دیجیتال (DOI): 10.30476/ijms.2025.105805.3975
نویسندگان
Amin Tamadon1، 2؛ Afshin Zare3؛ Mahdi Mahdipour4، 5؛ Aria Salehpour3؛ Nadiar M. Mussin6؛ Aliya A. Mussina7؛ Raisa A. Aringazina8؛ Ainash Duisenova9؛ Kulyash R. Zhilisbayeva10؛ Madina A. Kurmanalina11؛ Chong Fu* 12
1Department of Natural Sciences, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan
2Stem Cells Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran;
3PerciaVista R&D Co., Shiraz, Iran
4Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
5Department of Applied Cell Sciences, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
6Department of General Surgery, West Kazakhstan Medical University, Aktobe, Kazakhstan
7Department of Family Medicine No 1, Astana Medical University, Astana, Kazakhstan
8Department of Internal Medicine No. 1, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan
9Department of Psychology, West Kazakhstan Marat Ospanov Medical University, Aktobe, Republic of Kazakhstan
10Department of Languages, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan
11Department of Therapeutic and Prosthetic Dentistry, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan
12Health Management Center, The Fifth People's Hospital of Chongqing,Chongqing,400060, China
چکیده
Endometriosis, a complex gynecological disorder characterized by ectopic endometrial-like tissue, affects over 10% of women, causing chronic pain and infertility. Despite extensive research, its pathophysiology remains incompletely understood, with proposed mechanisms including inflammation, hormonal dysregulation, and retrograde menstruation. Given ethical and practical challenges in human studies, animal models are essential for investigating endometriosis pathogenesis and evaluating therapeutic interventions. This review examines hormone-related animal models of endometriosis, comparing induction methods (autotransplantation, xenotransplantation, and spontaneous models) and their applications in studying sex steroid hormones (SSH) and the hypothalamic-pituitary-gonadal (HPG) axis. We analyzed 158 studies (2010–2024) from PubMed Central/Medline, focusing on SSH and HPG axis involvement. A novel scoring system was developed to assess the model’s suitability based on species, induction method, pharmacological effects, hormonal/genetic evaluations, histological confirmation, feasibility, ethics, and cost. Non-human primate models, particularly spontaneous and hormone-induced baboon models, scored highest due to their physiological resemblance to humans. However, rodent models remain widely used due to practicality. Our findings highlight the need for improved preclinical models to enhance translational research, ultimately aiding in the development of targeted therapies for endometriosis. This comprehensive analysis provides a framework for selecting optimal animal models in future endometriosis research.

تازه های تحقیق

Amin Tamadon (Google Scholar)

Chong Fu (Google Scholar)

کلیدواژه‌ها
Sex steroid hormones؛ Estrogens؛ Progesterone؛ Endometriosis؛ Models, animal
مراجع
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