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Impact of Intravenous Lidocaine on Airway Complications and Hemodynamic Stability Following Emergency Laparoscopic Cholecystectomy: A Randomized Controlled Trial on Age-Related Differences | ||
| Bulletin of Emergency And Trauma | ||
| مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 15 شهریور 1404 اصل مقاله (552.34 K) | ||
| نوع مقاله: Original Article | ||
| شناسه دیجیتال (DOI): 10.30476/beat.2025.106751.1604 | ||
| نویسندگان | ||
| Mohammad Mmohammadifard1؛ Kowsar Ali Akbari1؛ Pooyan Ahanrobai2؛ Reza Pakzad3؛ Aminollah Vasigh* 4 | ||
| 1Anesthesia Department, Faculty of Medicine, Ilam University of Medical Sciences, Iran. | ||
| 2Anesthesiology Department, Imam Khomeini Hospital, Ilam University of Medical Sciences, Iran. | ||
| 3Assistant Professor of Epidemiology, Department of Epidemiology, School of Health, Ilam University of Medical Sciences. | ||
| 4Associate Professor of Anesthesiology, Department of Anesthesiology, School of Medical Sciences, Ilam University of Medical Sciences. | ||
| چکیده | ||
| Objectives: This randomized controlled trial aimed to evaluate the impact of intravenous lidocaine (1 mg/kg) administered prior to extubation on airway complications and hemodynamic stability in patients undergoing emergency laparoscopic cholecystectomy, with a focus on age-related differences. Methods: This single-center, prospective, randomized controlled trial was conducted at Imam Khomeini Hospital, Iran, from 2021 to 2023. Ninety patients undergoing emergency laparoscopic cholecystectomy were stratified into two age cohorts (<50 and ≥50 years) and randomized to receive either intravenous lidocaine (1 mg/kg) or standard extubation protocol. Primary outcomes included post-extubation airway complications (cough, laryngospasm, sore throat); secondary outcomes assessed hemodynamic and respiratory parameters. Results: Lidocaine exhibited divergent hemodynamic effects between age groups. In patients <50 years, systolic blood pressure (SBP) increased from 129.2 ± 16.4 mmHg to 133.1 ± 23.1 mmHg, while diastolic blood pressure (DBP) rose from 83.9 ± 14.4 mmHg to 92.3 ± 19.4 mmHg (both p<0.001). Conversely, in patients ≥50 years, SBP decreased from 160.5 ± 26.7 mmHg to 145.2 ± 19.7 mmHg, and DBP declined from 107.9 ± 19.5 mmHg to 99.0 ± 16.1 mmHg (both p<0.001). Airway complications showed non-significant trends, with lower cough incidence in the older group (15.6% vs. 31.8%) and no laryngospasm observed in this cohort. No serious adverse events (e.g., bronchospasm, arrhythmias) were reported. Conclusion: Intravenous lidocaine is safe, with trends suggesting potential reductions in airway complications during extubation in emergency laparoscopic cholecystectomy, particularly in older patients, though these findings did not reach statistical significance, likely due to limited statistical power. | ||
| کلیدواژه‌ها | ||
| Lidocaine؛ Cholecystectomy؛ laparoscopic؛ Hemodynamic | ||
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آمار تعداد مشاهده مقاله: 3 تعداد دریافت فایل اصل مقاله: 1 |
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