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Daneshparvar, Afrooz, Jamhiri, Iman, Handjani, Farhad, Hamidizadeh, Nasrin. (1404). The Role of Functional Polymorphisms of Apoptotic BAX (-248G>A) and Anti-Apoptotic BCL2 (-938C>A) Genes in the Development of Vitiligo: A Cross-sectional Study. سامانه مدیریت نشریات علمی, (), -. doi: 10.30476/ijms.2025.104043.3750
Afrooz Daneshparvar; Iman Jamhiri; Farhad Handjani; Nasrin Hamidizadeh. "The Role of Functional Polymorphisms of Apoptotic BAX (-248G>A) and Anti-Apoptotic BCL2 (-938C>A) Genes in the Development of Vitiligo: A Cross-sectional Study". سامانه مدیریت نشریات علمی, , , 1404, -. doi: 10.30476/ijms.2025.104043.3750
Daneshparvar, Afrooz, Jamhiri, Iman, Handjani, Farhad, Hamidizadeh, Nasrin. (1404). 'The Role of Functional Polymorphisms of Apoptotic BAX (-248G>A) and Anti-Apoptotic BCL2 (-938C>A) Genes in the Development of Vitiligo: A Cross-sectional Study', سامانه مدیریت نشریات علمی, (), pp. -. doi: 10.30476/ijms.2025.104043.3750
Daneshparvar, Afrooz, Jamhiri, Iman, Handjani, Farhad, Hamidizadeh, Nasrin. The Role of Functional Polymorphisms of Apoptotic BAX (-248G>A) and Anti-Apoptotic BCL2 (-938C>A) Genes in the Development of Vitiligo: A Cross-sectional Study. سامانه مدیریت نشریات علمی, 1404; (): -. doi: 10.30476/ijms.2025.104043.3750

The Role of Functional Polymorphisms of Apoptotic BAX (-248G>A) and Anti-Apoptotic BCL2 (-938C>A) Genes in the Development of Vitiligo: A Cross-sectional Study

Iranian Journal of Medical Sciences
مقالات آماده انتشار، اصلاح شده برای چاپ، انتشار آنلاین از تاریخ 28 مرداد 1404    اصل مقاله (549.13 K)
نوع مقاله: Original Article(s)
شناسه دیجیتال (DOI): 10.30476/ijms.2025.104043.3750
نویسندگان
Afrooz Daneshparvar1؛ Iman Jamhiri1؛ Farhad Handjani2، 3؛ Nasrin Hamidizadeh* 1
1Molecular Dermatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
2Department of Dermatology, University Hospitals Coventry & Warwickshire, Coventry, UK
3Department of Dermatology, Shiraz University of Medical Sciences, Shiraz, Iran
چکیده
Background: Vitiligo is an autoimmune skin disorder in which apoptosis plays an exceptionally vital role in its occurrence. Research has shown a strong association between the presence of polymorphisms and the occurrence of diseases. This study aimed to determine the association of BAX-248G>A and BCL2-938C>A polymorphisms with vitiligo.
Methods: This cross-sectional study utilized the tetra-primer amplification refractory mutation system polymerase chain reaction (ARMS PCR) in a cohort of vitiligo patients referred to the esteemed dermatology department of Shahid Faqihi Hospital in Shiraz between 2022 and 2023. The Chi square test and t test were used to analyze data, and logistic regression was employed to calculate odds ratios (ORs) and 95% confidence intervals (CIs) for vitiligo risk associated with BAX-248G>A, BCL2-938 C>A polymorphisms. P values<0.05 indicated statistical significance.
Results: From 112 healthy individuals and 107 vitiligo patients, our research uncovered a significant association between the C allele (BCL2-938C>A) and the chance of vitiligo, with the CC genotype increasing the risk of developing this disease (OR=2.59, 95% CI=1.66-4.05, P<0.001). We also found that in individuals with the GG genotype (BAX-248G>A), the risk of vitiligo is higher (OR=4.576, 95% CI=1.19-17.60, P=0.027). Parental kinship was strongly correlated with vitiligo (OR=1.83, 95% CI=1.00-3.33, P=0.048). Moreover, no significant association was observed between smoking and vitiligo. 
Conclusion: The results showed that BCL2-938C>A and BAX-248G>A polymorphisms may play a role in the pathogenesis of vitiligo and can be used as prognosis markers. However, further studies in larger groups and different populations are needed. 

تازه های تحقیق

Afrooz Daneshparvar (Google Scholar)

Nasrin Hamidizadeh (Google Scholar)

کلیدواژه‌ها
Polymorphism؛ Apoptosis؛ Bcl-2 associated X؛ B-cell lymphoma-2؛ Vitiligo
مراجع
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