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Evaluation of Antibacterial, Physicochemical, and Mechanical Properties of a Pit and Fissure Material Containing Silver Nanoparticles Attached to Metal-organic Framework | ||
| Journal of Dentistry | ||
| مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 27 مرداد 1404 اصل مقاله (852.99 K) | ||
| نوع مقاله: Original Article | ||
| شناسه دیجیتال (DOI): 10.30476/dentjods.2025.105348.2589 | ||
| نویسندگان | ||
| Niloofar Mokhtari1؛ Mahtab Memarpour* 2؛ Marzieh Alizadeh2؛ Azade Rafiee2 | ||
| 1Student Research Committee, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran. | ||
| 2Oral and Dental Disease Research Center, Dept. of Pediatric Dentistry, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran. | ||
| چکیده | ||
| Background: The use of nanotechnology in dentistry is considered as an innovative science to produce materials with more anti-caries properties. The release of metal ions and the longevity of the antibacterial activity of nanoparticles are critical factors that have garnered significant attention in recent research. Purpose: The study compared the antibacterial effects, physicochemical, and mechanical properties of a resin -based fissure sealant (FS) dental material, plus silver (Ag) nanoparticles (NPs) doped copper-based metal-organic framework NPs (Ag@HKUST-1) to FS alone. Materials and Method: HKUST-1 and Ag@HKUST-1 were characterized by Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), Scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDS), and Dynamic light scattering (DLS). Then, 0.1%, 0.5%, and 1% Ag@HKUST-1 plus a FS (ClinproTM, 3M, USPE, USA) compared to FS alone (control group). The antibacterial effects against Streptococcus mutans (s. mutans) were assessed with confocal laser scanning microscopy (CLSM), colony-forming unit (CFU) analysis, and SEM. Metabolic activity and cytotoxicity were evaluated by MTT assay and SEM. Results: The results confirmed the successful synthesis of HKUST-1 and Ag@HKUST-1. Compared to control, the Ag@HKUST-1 + FS groups significantly reduced bacterial growth (p Value < 0.001). Both 0.5% and 1% Ag@HKUST-1 + FS groups had nonsignificant lower biocompatibility than the control group (p> 0.05). Based on the results, we selected the 0.5% Ag@HKUST-1 + FS group. The 0.5% Ag@HKUST-1 + FS group did not reduce shear bond strength, microleakage, or increase color change compared to the control (all p> 0.05). Depth of cure, microhardness, flowability, and flexural strength in the 0.5% Ag@HKUST-1 + FS group were higher than the control (all p< 0.05). The release of copper (Cu) ions increased between days 4–60, and Ag ions increased between days 1–21 and 30–60. Conclusion: The antibacterial, physicochemical, and mechanical properties of 0.5% Ag@HKUST-1 + FS showed that it might be suitable alternative to conventional FS. | ||
| کلیدواژه‌ها | ||
| Antibacterial؛ Fissure sealant؛ Mechanical properties؛ Nanoparticles | ||
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آمار تعداد مشاهده مقاله: 3 تعداد دریافت فایل اصل مقاله: 2 |
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