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Barghamadi, Bita, Ghorat, Fereshteh, Dastjerdi, Ali, Karimi, Asrin, Peyghambari, Robab. (1404). Lipid-Lowering Effect of Citrullus colocynthis in Diabetic Patients. سامانه مدیریت نشریات علمی, (), -. doi: 10.30476/ijns.2025.105628.1399
Bita Barghamadi; Fereshteh Ghorat; Ali Dastjerdi; Asrin Karimi; Robab Peyghambari. "Lipid-Lowering Effect of Citrullus colocynthis in Diabetic Patients". سامانه مدیریت نشریات علمی, , , 1404, -. doi: 10.30476/ijns.2025.105628.1399
Barghamadi, Bita, Ghorat, Fereshteh, Dastjerdi, Ali, Karimi, Asrin, Peyghambari, Robab. (1404). 'Lipid-Lowering Effect of Citrullus colocynthis in Diabetic Patients', سامانه مدیریت نشریات علمی, (), pp. -. doi: 10.30476/ijns.2025.105628.1399
Barghamadi, Bita, Ghorat, Fereshteh, Dastjerdi, Ali, Karimi, Asrin, Peyghambari, Robab. Lipid-Lowering Effect of Citrullus colocynthis in Diabetic Patients. سامانه مدیریت نشریات علمی, 1404; (): -. doi: 10.30476/ijns.2025.105628.1399

Lipid-Lowering Effect of Citrullus colocynthis in Diabetic Patients

International Journal of Nutrition Sciences
مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 26 مرداد 1404    اصل مقاله (431.3 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.30476/ijns.2025.105628.1399
نویسندگان
Bita Barghamadi* 1؛ Fereshteh Ghorat2؛ Ali Dastjerdi3؛ Asrin Karimi4؛ Robab Peyghambari2
1Emdad Hospital Research Center, Sabzevar University of Medical Sciences, Sabzevar, Iran
2Non-Communicable Diseases Research Center, Sabzevar University of Medical Sciences, Sabzevar, Iran
3Student Research Committee, Sabzevar University of Medical Sciences, Sabzevar, Iran
4Department of Epidemiology and Statistics, Deputy of Health, Sanandaj University of Medical sciences, Sanandaj, Iran
چکیده
Background: Citrullus colocynthis (C. colocynthis) is a traditional medicinal plant used as an antidiabetic herb in the northeast of Iran. However, its effects on diabetes-related disorders, such as diabetic dyslipidemia have not been extensively studied. This study aimed to evaluate the effect of C. colocynthis on the lipid profile of type 2 diabetes patients with dyslipidemia.
Methods: Seventy-six diabetic patients with dyslipidemia who attended the diabetes clinic in Sabzevar, Iran were randomly assigned to either an intervention group (n=38) to receive C. colocynthis capsules (125 mg) or a placebo group (n=38) receiving starch and Tragacanth powder (125 mg) once daily for 8 weeks. The primary outcome was the change in low-density lipoprotein cholesterol (LDL-C) level at 8th week. Secondary outcomes included modifications in total cholesterol, triglycerides, and high-density lipoprotein cholesterol (HDL-C) levels.
Results: After 8 weeks, the intervention group showed a significant reduction in LDL-C level compared to baseline (p=0.001) and to the placebo group (p=0.006). No significant differences were observed between the C. colocynthis and placebo groups for total cholesterol (p=0.1), HDL-C (p=0.6), and triglycerides (p=0.06). No adverse events were recorded during the study.
Conclusion: In type 2 diabetic patients with dyslipidemia, C. colocynthis supplementation could significantly decline the LDL-C level over 8 weeks when compared to placebo. Further studies with larger sample sizes and longer follow-up periods are needed to confirm these findings and evaluate the long-term efficacy and safety of C. colocynthis.
کلیدواژه‌ها
Diabetes mellitus؛ Citrullus colocynthis؛ Dyslipidemia؛ Herbal medicine؛ Traditional medicine
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