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Could L-Arginine Be a Feasible Treatment for Chronic Anal Fissure? | ||
Iranian Journal of Colorectal Research | ||
دوره 13، شماره 1، خرداد 2025، صفحه 30-31 اصل مقاله (477.36 K) | ||
نوع مقاله: Commentary | ||
شناسه دیجیتال (DOI): 10.30476/acrr.2025.107961.1253 | ||
نویسندگان | ||
Sara Shojaei-Zarghani؛ Seyed Vahid Hosseini* | ||
Colorectal Research Center, Shiraz University of Medical Sciences, Shiraz, Iran | ||
چکیده | ||
Anal fissure is a common benign anorectal condition characterized by a small, painful ulcer in the skin of the anal canal below the dentate line, which gradually leads to spasm of the internal sphincter muscle. | ||
تازه های تحقیق | ||
Sara Shojaei-Zarghani (Google Scholar) Seyed Vahid Hosseini (Google Scholar) | ||
کلیدواژهها | ||
Arginine؛ Fissure in ano؛ Conservative treatment | ||
مراجع | ||
1. Jahnny B, Ashurst JV. Anal Fissures. [Updated 2022 Nov 14]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-. Available from: https://www.ncbi. nlm.nih.gov/books/NBK526063/. 2. Chen B, Liu Y, Wang Y, Wang Q. Causal relationship between body mass index and anal fistula: a twosample Mendelian randomization study. Frontiers in Genetics. 2024;15:1406231. 3. Mapel DW, Schum M, Von Worley A. The epidemiology and treatment of anal fissures in a populationbased cohort. BMC gastroenterology. 2014;14(1):129. 4. Zuhan A, Widyastuti P, Mawaddah A, Indrasari AD, Alawiya BH, Priyahita PD, et al. Anal Fissure: Clinical Practice, Diagnosis in Primary Care and Management Guideline. A Literature Reviews. Lombok Health And Science Journal. 2024;3(1):24-35. 5. Lu Y, Kwaan MR, Lin AY. Diagnosis and treatment of anal fissures in 2021. JAMA. 2021;325(7):688-9. 6. Acheson A, Griffin N, Scholefield J, Wilson V. L-Arginine-induced relaxation of the internal anal sphincter is not mediated by nitric oxide. Journal of British Surgery. 2003;90(9):1155-62. 7. Hnia K, Gayraud J, Hugon G, Ramonatxo M, De La Porte S, Matecki S, et al. L-arginine decreases inf lammation and modulates the nuclear factor-κB/matrix metalloproteinase cascade in mdx muscle fibers. The American journal of pathology. 2008;172(6):1509-19. 8. Griffin N, Zimmerman D, Briel J, Gruss H-J, Jonas M, Acheson A, et al. Topical L-arginine gel lowers resting anal pressure: possible treatment for anal fissure. Diseases of the colon & rectum. 2002;45(10):1332-6. 9. Gosselink MP, Darby M, Zimmerman D, Gruss H, Schouten WRJDotc. Treatment of chronic anal fissure by application of L-arginine gel: a phase II study in 15 patients. Diseases of the colon & rectum. 2005;48(4):832-7. 10. Khalighi Sikaroudi M, Sedaghat M, Shidfar F, Talebi S, Hosseini- Baharanchi FS, Masoodi M, et al. l-Arginine is a feasible supplement to heal chronic anal fissure via reducing internal anal sphincter pressure: a randomized clinical trial study. Amino Acids. 2023;55(2):193-202. 11. Prins H, Gosselink MP, Mitales L, Buise M, Teerlink T, Esser C, et al. The effect of oral administration of L–arginine on anal resting pressure and anodermal blood flow in healthy volunteers. Techniques in Coloproctology. 2005;9(3):229-33. | ||
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