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Khoshandam, Mohadeseh, Naserpour, Leila, Hedayati Goudarzi, Mohammad Taghi, Soltaninejad, Hossein, Zare-Zardini, Hadi, Hoseiny, Ashraf Alsavdat, Golpar Raboki, Neda, Mousavi, Elahe Sadat, Salami, Mohammad Ali. (1404). Regulatory Roles of MicroRNAs in Female and Male Human Reproduction: A Narrative Review. سامانه مدیریت نشریات علمی, (), -. doi: 10.30476/ijms.2025.104375.3797
Mohadeseh Khoshandam; Leila Naserpour; Mohammad Taghi Hedayati Goudarzi; Hossein Soltaninejad; Hadi Zare-Zardini; Ashraf Alsavdat Hoseiny; Neda Golpar Raboki; Elahe Sadat Mousavi; Mohammad Ali Salami. "Regulatory Roles of MicroRNAs in Female and Male Human Reproduction: A Narrative Review". سامانه مدیریت نشریات علمی, , , 1404, -. doi: 10.30476/ijms.2025.104375.3797
Khoshandam, Mohadeseh, Naserpour, Leila, Hedayati Goudarzi, Mohammad Taghi, Soltaninejad, Hossein, Zare-Zardini, Hadi, Hoseiny, Ashraf Alsavdat, Golpar Raboki, Neda, Mousavi, Elahe Sadat, Salami, Mohammad Ali. (1404). 'Regulatory Roles of MicroRNAs in Female and Male Human Reproduction: A Narrative Review', سامانه مدیریت نشریات علمی, (), pp. -. doi: 10.30476/ijms.2025.104375.3797
Khoshandam, Mohadeseh, Naserpour, Leila, Hedayati Goudarzi, Mohammad Taghi, Soltaninejad, Hossein, Zare-Zardini, Hadi, Hoseiny, Ashraf Alsavdat, Golpar Raboki, Neda, Mousavi, Elahe Sadat, Salami, Mohammad Ali. Regulatory Roles of MicroRNAs in Female and Male Human Reproduction: A Narrative Review. سامانه مدیریت نشریات علمی, 1404; (): -. doi: 10.30476/ijms.2025.104375.3797

Regulatory Roles of MicroRNAs in Female and Male Human Reproduction: A Narrative Review

Iranian Journal of Medical Sciences
مقالات آماده انتشار، اصلاح شده برای چاپ، انتشار آنلاین از تاریخ 25 مرداد 1404    اصل مقاله (305.87 K)
نوع مقاله: Review Article
شناسه دیجیتال (DOI): 10.30476/ijms.2025.104375.3797
نویسندگان
Mohadeseh Khoshandam1، 2؛ Leila Naserpour1، 3؛ Mohammad Taghi Hedayati Goudarzi4؛ Hossein Soltaninejad* 5؛ Hadi Zare-Zardini6؛ Ashraf Alsavdat Hoseiny1؛ Neda Golpar Raboki1؛ Elahe Sadat Mousavi1؛ Mohammad Ali Salami7
1Department of Reproductive Biology, Academic Center for Education, Culture, and Research (ACECR), Qom, Iran
2National Institute of Genetic Engineering and Biotechnology (NIGEB), Tehran, Iran
3Department of Tissue Engineering, Qom University of Medical Sciences, Qom, Iran
4Department of Cardiology, School of Medicine, Babol University of Medical Sciences, Babol, Iran
5Department of Stem Cells Technology and Tissue Regeneration, Faculty of Interdisciplinary Science and Technologies, Tarbiat Modares University, Tehran, Iran
6Department of Biomedical Engineering, Meybod University, Meybod, Iran
7Department of Biomaterials, Nanotechnology and Tissue Engineering, School of Advanced Technologies in Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
چکیده
The role of microRNAs (miRNAs) in human reproduction represents an area of research, as these regulatory molecules appear to play essential roles in reproductive function. However, the current understanding of miRNAs’ regulatory mechanisms in male and female reproduction remains incomplete, with considerable contradictory evidence in the literature. This targeted review aimed to analyze high-quality studies published to date on miRNA expression patterns in female and male reproduction to elucidate their biological roles and associations with infertility, thereby updating knowledge in this field. A comprehensive review of the literature was conducted using different electronic databases and search engines, including PubMed Central, MEDLINE, and Google Scholar from the earliest available records up to 2023. This search identified 18,100 articles related to miRNA expression in infertility, polycystic ovary syndrome (PCOS), endometriosis, and biomarkers, of which 72 met our criteria for further analysis. The findings of the present study revealed that specific, stable miRNA populations exist in different tissues and cells, potentially influencing spermatogenesis and oogenesis. The extensive review of studies suggested a consistent relationship between aberrant miRNA expression patterns and infertility. Consequently, the miRNAs identified in this review might serve as valuable biomarkers for both male and female infertility and could lead to the development of novel and specialized treatments.

تازه های تحقیق

Mohadeseh Khoshandam (Google Scholar)

Hossein Soltaninejad (Google Scholar)

کلیدواژه‌ها
Infertility؛ MicroRNAs؛ Spermatogenesis؛ Polycystic ovary syndrome؛ Endometriosis؛ Biomarkers
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آمار
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