LinkedIn

 آمار

تعداد نشریات20
تعداد شماره‌ها1,218
تعداد مقالات11,135
تعداد مشاهده مقاله76,505,480
تعداد دریافت فایل اصل مقاله100,832,627
Mehrabadi, Fatemeh, Arian, Mahdieh, Badiee, Zahra. (1404). Effect of Therapy Reminder Application on Treatment Adherence in Adults with Beta-Thalassemia Major: A Randomized Clinical Trial. سامانه مدیریت نشریات علمی, 50(9), 597-606. doi: 10.30476/ijms.2025.104207.3783
Fatemeh Mehrabadi; Mahdieh Arian; Zahra Badiee. "Effect of Therapy Reminder Application on Treatment Adherence in Adults with Beta-Thalassemia Major: A Randomized Clinical Trial". سامانه مدیریت نشریات علمی, 50, 9, 1404, 597-606. doi: 10.30476/ijms.2025.104207.3783
Mehrabadi, Fatemeh, Arian, Mahdieh, Badiee, Zahra. (1404). 'Effect of Therapy Reminder Application on Treatment Adherence in Adults with Beta-Thalassemia Major: A Randomized Clinical Trial', سامانه مدیریت نشریات علمی, 50(9), pp. 597-606. doi: 10.30476/ijms.2025.104207.3783
Mehrabadi, Fatemeh, Arian, Mahdieh, Badiee, Zahra. Effect of Therapy Reminder Application on Treatment Adherence in Adults with Beta-Thalassemia Major: A Randomized Clinical Trial. سامانه مدیریت نشریات علمی, 1404; 50(9): 597-606. doi: 10.30476/ijms.2025.104207.3783

Effect of Therapy Reminder Application on Treatment Adherence in Adults with Beta-Thalassemia Major: A Randomized Clinical Trial

Iranian Journal of Medical Sciences
مقاله 2، دوره 50، شماره 9، آذر 2025، صفحه 597-606    اصل مقاله (619.46 K)
نوع مقاله: Original Article(s)
شناسه دیجیتال (DOI): 10.30476/ijms.2025.104207.3783
نویسندگان
Fatemeh Mehrabadi1، 2؛ Mahdieh Arian* 2، 3؛ Zahra Badiee4
1Department of Intensive Care Nursing, School of Nursing and Midwifery, Mashhad University of Medical Sciences, Mashhad, Iran
2Nursing and Midwifery Care Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
3Department of Medical-Surgical Nursing, School of Nursing and Midwifery, Mashhad University of Medical Sciences, Mashhad, Iran
4Department of Pediatric Hematology and Oncology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
چکیده
Background: Non-adherence to treatment in patients with beta-thalassemia major (BTM) presents a significant challenge in effective disease management. This study aimed to assess the effect of a therapy reminder application (app) on treatment adherence in adult patients with BTM in Mashhad in 2024.
Methods: A randomized clinical trial was conducted in 2024 at a thalassemia clinic affiliated with Mashhad University of Medical Sciences (Mashhad, Iran). Participants were randomly assigned to the intervention and control groups, using permuted block randomization, with concealed allocation. The intervention group used the ThalaMe therapy reminder app for 8 weeks (February-July 2024), while the control group received standard care. Medication adherence was measured using the Morisky Medication Adherence Scale (MMAS-8) and the Chronic Disease Treatment Adherence Questionnaire (CDTAQ) before and after the intervention. Statistical analysis was conducted using SPSS software, using paired t tests or Wilcoxon signed-rank tests for within-group comparisons and independent t tests or Mann-Whitney U tests for between-group comparisons. P<0.05 was considered statistically significant.
Results: The study included 76 adult patients with BTM, equally distributed between the intervention and control groups (n=38 each). Baseline measurements showed no significant differences between groups in either MMAS-8 scores (P=0.75) or CDTAQ scores (P=0.11). The MMAS-8 was inversely scored, with lower scores indicating higher adherence. Following the 8-week intervention period, the group using the ThalaMe app demonstrated significantly better adherence outcomes (1.05±0.78) than the controls (2.92±1.4, P<0.001). The intervention group had significantly higher CDTAQ scores (185.5±8.07) than the control group (151.79±27.08, P<0.001).
Conclusion: The therapy reminder app significantly enhanced medication adherence and treatment management in patients with BTM, while simultaneously enhancing patient and family engagement through counseling.
Trial registration number: IRCT20240222061079N1

تازه های تحقیق

Fatemeh Mehrabadi (Google Scholar)

Mahdieh Arian (Google Scholar)

کلیدواژه‌ها
Thalassemia؛ Patient compliance؛ Medication adherence؛ Treatment adherence and compliance؛ Telemedicine
سایر فایل های مرتبط با مقاله
مراجع
  1. Arian M, Soleimani M, Fakhr-Movahedi A, Oghazian MB, Badiee Z. Quality of life in patients with thalassemia major: A concept analysis using Rodgers’ evolutionary method. Journal of Pediatric Perspectives. 2020;8:11197-217.
  2. Galanello R, Origa R. Beta-thalassemia. Orphanet J Rare Dis. 2010;5:11. doi: 10.1186/1750-1172-5-11. PubMed PMID: 20492708; PubMed Central PMCID: PMCPMC2893117.
  3. Arian M, Badiee Z, Soleimani M. Investigating Challenges Facing the Improvement of Health Related Quality of Life in Iranian β-Thalassemia Major Patients: A Qualitative Study. Journal of Pediatric Perspectives. 2021;9:14457-73.
  4. Arian M, Mirmohammadkhani M, Ghorbani R, Soleimani M. Health-related quality of life (HRQoL) in beta-thalassemia major (beta-TM) patients assessed by 36-item short form health survey (SF-36): a meta-analysis. Qual Life Res. 2019;28:321-34. doi: 10.1007/s11136-018-1986-1. PubMed PMID: 30194626.
  5. Chauke GD, Nakwafila O, Chibi B, Sartorius B, Mashamba-Thompson T. Factors influencing poor medication adherence amongst patients with chronic disease in low-and-middle-income countries: A systematic scoping review. Heliyon. 2022;8:e09716. doi: 10.1016/j.heliyon.2022.e09716. PubMed PMID: 35770147; PubMed Central PMCID: PMCPMC9234585.
  6. Onder G, Bonassi S, Abbatecola AM, Folino-Gallo P, Lapi F, Marchionni N, et al. High prevalence of poor quality drug prescribing in older individuals: a nationwide report from the Italian Medicines Agency (AIFA). J Gerontol A Biol Sci Med Sci. 2014;69:430-7. doi: 10.1093/gerona/glt118. PubMed PMID: 23913935.
  7. Naderi SH, Bestwick JP, Wald DS. Adherence to drugs that prevent cardiovascular disease: meta-analysis on 376,162 patients. Am J Med. 2012;125:882-7 e1. doi: 10.1016/j.amjmed.2011.12.013. PubMed PMID: 22748400.
  8. Peng Y, Wang H, Fang Q, Xie L, Shu L, Sun W, et al. Effectiveness of Mobile Applications on Medication Adherence in Adults with Chronic Diseases: A Systematic Review and Meta-Analysis. J Manag Care Spec Pharm. 2020;26:550-61. doi: 10.18553/jmcp.2020.26.4.550. PubMed PMID: 32223596; PubMed Central PMCID: PMCPMC10391210.
  9. Jonassaint J, De Castro LM. Information technology use by patients with hemoglobinopathies. Blood. 2012;120:4698. doi: 10.1182/blood.V120.21.4698.4698.
  10. Santo K, Chow CK, Thiagalingam A, Rogers K, Chalmers J, Redfern J. MEDication reminder APPs to improve medication adherence in Coronary Heart Disease (MedApp-CHD) Study: a randomised controlled trial protocol. BMJ Open. 2017;7:e017540. doi: 10.1136/bmjopen-2017-017540. PubMed PMID: 28993388; PubMed Central PMCID: PMCPMC5640083.
  11. Santo K, Richtering SS, Chalmers J, Thiagalingam A, Chow CK, Redfern J. Mobile Phone Apps to Improve Medication Adherence: A Systematic Stepwise Process to Identify High-Quality Apps. JMIR Mhealth Uhealth. 2016;4:e132. doi: 10.2196/mhealth.6742. PubMed PMID: 27913373; PubMed Central PMCID: PMCPMC5161780.
  12. Ng R, Carter SR, El-Den S. The impact of mobile applications on medication adherence: a systematic review. Transl Behav Med. 2020;10:1419-35. doi: 10.1093/tbm/ibz125. PubMed PMID: 31384950.
  13. Badawy SM, Morrone K, Thompson A, Palermo TM. Computer and mobile technology interventions to promote medication adherence and disease management in people with thalassemia. Cochrane Database Syst Rev. 2019;6:CD012900. doi: 10.1002/14651858.CD012900.pub2. PubMed PMID: 31250923; PubMed Central PMCID: PMCPMC6598413.
  14. Bal P, Shamsir S, Warid N, Yahya A, Yunus J, Supriyanto E, et al., editors. MHealth application: Mobile thalassemia patient management application. 2014 IEEE Conference on Biomedical Engineering and Sciences (IECBES); 2014. doi: 10.1109/IECBES.2014.7047618.
  15. Fatemi NS, Rafii F, Hajizadeh E, Modanloo M. Psychometric properties of the adherence questionnaire in patients with chronic disease: A mix method study. Koomesh. 2018;20:179-91.
  16. Morisky DE, Ang A, Krousel-Wood M, Ward HJ. Predictive validity of a medication adherence measure in an outpatient setting. J Clin Hypertens (Greenwich). 2008;10:348-54. doi: 10.1111/j.1751-7176.2008.07572.x. PubMed PMID: 18453793; PubMed Central PMCID: PMCPMC2562622.
  17. Zhou L, Bao J, Setiawan IMA, Saptono A, Parmanto B. The mHealth App Usability Questionnaire (MAUQ): Development and Validation Study. JMIR Mhealth Uhealth. 2019;7:e11500. doi: 10.2196/11500. PubMed PMID: 30973342; PubMed Central PMCID: PMCPMC6482399.
  18. Lawshe CH. A quantitative approach to content validity. Personnel psychology. 1975;28:563-75. doi: 10.1111/j.1744-6570.1975.tb01393.x.
  19. Waltz CF, Bausell BR. Nursing research: design statistics and computer analysis. Philadelphia: Davis Fa; 1981.
  20. Mortezaei S, Khanjani S, Mohammadnejad E, Mokari AP. Design and Evaluation of an mHealth Application in Self-Management of Post-Traumatic Stress Disorder. Journal of Health and Biomedical Informatics. 2023;9:196-208. doi: 10.34172/jhbmi.2023.01.
  21. Aksoy MK, Demirci H, Karlibel IA, Ayar K, Ture DA, Altan L. Health literacy and medication adherence in fibromyalgia. European Health Literacy Journal, 1 (1). 2021:1-11. doi: 10.29228/ehlj.51016.
  22. Laghousi D, Rezaie F, Alizadeh M, Asghari Jafarabadi M. The eight-item Morisky Medication Adherence Scale: validation of its Persian version in diabetic adults. Caspian J Intern Med. 2021;12:77-83. doi: 10.22088/cjim.12.1.77. PubMed PMID: 33680402; PubMed Central PMCID: PMCPMC7919181.
  23. Barzegari S, Sharifi Kia A, Bardus M, Stoyanov SR, GhaziSaeedi M, Rafizadeh M. The Persian Version of the Mobile Application Rating Scale (MARS-Fa): Translation and Validation Study. JMIR Form Res. 2022;6:e42225. doi: 10.2196/42225. PubMed PMID: 36469402; PubMed Central PMCID: PMCPMC9764158.
  24. Nouri R, Samouei R, Zare-Farashbandi F, Shirvanian-Dehkordi M. Validation of the Persian Version of the Mobile Application Rating Scale (MARS) in the field of pregnancy. The Iranian Journal of Obstetrics, Gynecology and Infertility. 2024;27:1-9.
  25. Najafi Ghezeljeh T, Davoudi M, Vakilian F. The impact of using a smartphone-based application on medication adherence in people with heart failure. Nursing And Midwifery Journal. 2019;17:494-504.
  26. Efird J. Blocked randomization with randomly selected block sizes. Int J Environ Res Public Health. 2011;8:15-20. doi: 10.3390/ijerph8010015. PubMed PMID: 21318011; PubMed Central PMCID: PMCPMC3037057.
  27. Andrade C. Intent-to-Treat (ITT) vs Completer or Per-Protocol Analysis in Randomized Controlled Trials. Indian J Psychol Med. 2022;44:416-8. doi: 10.1177/02537176221101996. PubMed PMID: 35949630; PubMed Central PMCID: PMCPMC9301744.
  28. Sainani KL. Making sense of intention-to-treat. PM R. 2010;2:209-13. doi: 10.1016/j.pmrj.2010.01.004. PubMed PMID: 20359686.
  29. Poorcheraghi H, Negarandeh R, Pashaeypoor S, Jorian J. Effect of using a mobile drug management application on medication adherence and hospital readmission among elderly patients with polypharmacy: a randomized controlled trial. BMC Health Serv Res. 2023;23:1192. doi: 10.1186/s12913-023-10177-4. PubMed PMID: 37919712; PubMed Central PMCID: PMCPMC10621100.
  30. Torkabad SM, Bonabi TN, Heidari S. Effectiveness of smartphone-based medication reminder application on medication adherence of patients with essential hypertension: A clinical trial study. Journal of Nursing and Midwifery Sciences. 2020;7:219-25. doi: 10.4103/JNMS.JNMS_16_20.
  31. Santo K, Singleton A, Rogers K, Thiagalingam A, Chalmers J, Chow CK, et al. Medication reminder applications to improve adherence in coronary heart disease: a randomised clinical trial. Heart. 2019;105:323-9. doi: 10.1136/heartjnl-2018-313479. PubMed PMID: 30150326.
  32. Morawski K, Ghazinouri R, Krumme A, Lauffenburger JC, Lu Z, Durfee E, et al. Association of a Smartphone Application With Medication Adherence and Blood Pressure Control: The MedISAFE-BP Randomized Clinical Trial. JAMA Intern Med. 2018;178:802-9. doi: 10.1001/jamainternmed.2018.0447. PubMed PMID: 29710289; PubMed Central PMCID: PMCPMC6145760.
  33. Chawsamtong S, Jetsrisuparb A, Kengkla K, Jaisue S. Effect of drug use calendar on adherence to iron chelation therapy in young thalassemia patients. Pharm Pract (Granada). 2022;20:2570. doi: 10.18549/PharmPract.2022.1.2570. PubMed PMID: 35497900; PubMed Central PMCID: PMCPMC9014910.
  34. Spetz K, Hult M, Olbers T, Bonn S, Svedjeholm S, Lagerros YT, et al. A smartphone application to improve adherence to vitamin and mineral supplementation after bariatric surgery. Obesity (Silver Spring). 2022;30:1973-82. doi: 10.1002/oby.23536. PubMed PMID: 36050801; PubMed Central PMCID: PMCPMC9805084
  35. Abu-El-Noor NI, Aljeesh YI, Bottcher B, Abu-El-Noor MK. Impact of a mobile phone app on adherence to treatment regimens among hypertensive patients: A randomised clinical trial study. Eur J Cardiovasc Nurs. 2021;20:428-35. doi: 10.1177/1474515120938235. PubMed PMID: 32631080.
  36. Karaaslan-Eser A, Ayaz-Alkaya S. The effect of a mobile application on treatment adherence and symptom management in patients using oral anticancer agents: A randomized controlled trial. Eur J Oncol Nurs. 2021;52:101969. doi: 10.1016/j.ejon.2021.101969. PubMed PMID: 33991868.
  37. Jimenez-Chala EA, Durantez-Fernandez C, Martin-Conty JL, Mohedano-Moriano A, Martin-Rodriguez F, Polonio-Lopez B. Use of Mobile Applications to Increase Therapeutic Adherence in Adults: A Systematic Review. J Med Syst. 2022;46:87. doi: 10.1007/s10916-022-01876-2. PubMed PMID: 36272023.
  38. Pabbaraju A. ThalPal Android App-A medication alarm app to enhance medication adherence in adolescents with Thalassemia. 2015.
آمار
تعداد مشاهده مقاله: 1,105
تعداد دریافت فایل اصل مقاله: 287


سامانه مدیریت نشریات علمی. قدرت گرفته از سیناوب