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Maghsoumi-Norouzabad, Leila, Bagherzadeh-Karimi, Alireza, Aliakbari Majd, Shabnam, Hosseini, Leila, Shahi, Fatemeh. (1404). The Effects of Prebiotic Dietary Fibers, Probiotics, and Synbiotics on Gut Permeability and Immunity: A Systematic Review. سامانه مدیریت نشریات علمی, 50(8), 500-529. doi: 10.30476/ijms.2024.102363.3525
Leila Maghsoumi-Norouzabad; Alireza Bagherzadeh-Karimi; Shabnam Aliakbari Majd; Leila Hosseini; Fatemeh Shahi. "The Effects of Prebiotic Dietary Fibers, Probiotics, and Synbiotics on Gut Permeability and Immunity: A Systematic Review". سامانه مدیریت نشریات علمی, 50, 8, 1404, 500-529. doi: 10.30476/ijms.2024.102363.3525
Maghsoumi-Norouzabad, Leila, Bagherzadeh-Karimi, Alireza, Aliakbari Majd, Shabnam, Hosseini, Leila, Shahi, Fatemeh. (1404). 'The Effects of Prebiotic Dietary Fibers, Probiotics, and Synbiotics on Gut Permeability and Immunity: A Systematic Review', سامانه مدیریت نشریات علمی, 50(8), pp. 500-529. doi: 10.30476/ijms.2024.102363.3525
Maghsoumi-Norouzabad, Leila, Bagherzadeh-Karimi, Alireza, Aliakbari Majd, Shabnam, Hosseini, Leila, Shahi, Fatemeh. The Effects of Prebiotic Dietary Fibers, Probiotics, and Synbiotics on Gut Permeability and Immunity: A Systematic Review. سامانه مدیریت نشریات علمی, 1404; 50(8): 500-529. doi: 10.30476/ijms.2024.102363.3525

The Effects of Prebiotic Dietary Fibers, Probiotics, and Synbiotics on Gut Permeability and Immunity: A Systematic Review

Iranian Journal of Medical Sciences
مقاله 2، دوره 50، شماره 8، آبان 2025، صفحه 500-529    اصل مقاله (992.49 K)
نوع مقاله: Review Article
شناسه دیجیتال (DOI): 10.30476/ijms.2024.102363.3525
نویسندگان
Leila Maghsoumi-Norouzabad* 1، 2؛ Alireza Bagherzadeh-Karimi2، 3؛ Shabnam Aliakbari Majd4؛ Leila Hosseini5؛ Fatemeh Shahi6
1Traditional Medicine and Hydrotherapy Research Center, Ardabil University of Medical Sciences, Ardabil, Iran
2Research Center for Integrative Medicine in Aging, Aging Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran
3Department of Persian Medicine, School of Traditional Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
4Food and Drug Administration, Saveh University of Medical Sciences, Saveh, Iran
5Research Center of Psychiatry and Behavioral Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
6Infectious and Tropical Diseases Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
چکیده
Background: Modulation of intestinal barrier, which function through zonulin pathway downregulation, represents a promising therapeutic strategy for chronic diseases. This systematic review aimed to evaluate the effects of prebiotic dietary fibers, probiotics, and synbiotics on intestinal permeability and immunity. 
Methods: A systematic literature search of the EMBASE, PubMed, Web of Science, and Scopus electronic databases was conducted from database inception up to May 2024, supplemented by manual reference list searches. Included studies met the following criteria: (a) English language publications; (b) clinical trials; (c) investigated each factor of serum or fecal zonulin levels, serum or fecal calprotectin, glucagon-likepeptide-2 (GLP-2), short chain fatty acids (SCFAs), long chain fatty acids (LCFAs), fecal bile acid (BA), LPS-binding protein (LBP), lipopolysaccharide (LPS), intestinal microbiota composition, or inflammatory factors such as interleukin 6 (IL-6) and high-sensitivity C-reactive protein (hs-CRP); (d) supplemented prebiotic dietary fibers, probiotics, or symbiotics. Studies were excluded if they contained insufficient data or involved supplementation alongside other interventions. The study quality and risk of bias were assessed using Jadad’s Score.
Results: A total of 36 studies were included in this review. Of these, 14 articles (n=580 participants) evaluated the effect of dietary prebiotics, 18 articles (n=1502 participants) evaluated the effect of probiotics, and six articles (n=517 participants) examined the effect of synbiotics on intestinal health and immunity markers. According to the evidence presented in this study, prebiotic whole foods or food enriched with prebiotics, probiotics, and synbiotics might have favorable effects on the serum levels of zonulin as a measure of intestinal permeability. The effects on GLP-2, gut microbiota, and their metabolites (e.g., LCFAs/SCFAs and BA) were contradictory and inconclusive. Some studies indicated increased levels of Bifidobacteria and SCFA with prebiotic supplementation or prebiotics-enriched food products. Fecal calprotectin (as an important marker of the local gut inflammation), tumor necrosis factor-α (TNF-α), and hs-CRP were unaffected in most studies. 
Conclusion: The lack of consistent replication across studies made it difficult to draw definitive conclusions about the effects of prebiotics, probiotics, and synbiotics on gut-related health and immunity. Therefore, further evidence is required before definitive recommendations can be established. 

تازه های تحقیق

Leila Maghsoumi-Norouzabad (Google Scholar)

کلیدواژه‌ها
Probiotic؛ Synbiotic؛ Intestinal barrier function؛ Inflammation mediators؛ Zonulin
سایر فایل های مرتبط با مقاله
مراجع
  1. Pellegrini C, Fornai M, D’Antongiovanni V, Antonioli L, Bernardini N, Derkinderen P. The intestinal barrier in disorders of the central nervous system. Lancet Gastroenterol Hepatol. 2023;8:66-80. doi: 10.1016/S2468-1253(22)00241-2. PubMed PMID: 36334596.
  2. Fasano A. Zonulin and its regulation of intestinal barrier function: the biological door to inflammation, autoimmunity, and cancer. Physiol Rev. 2011;91:151-75. doi: 10.1152/physrev.00003.2008. PubMed PMID: 21248165.
  3. Wang W, Uzzau S, Goldblum SE, Fasano A. Human zonulin, a potential modulator of intestinal tight junctions. J Cell Sci. 2000;113 Pt 24:4435-40. doi: 10.1242/jcs.113.24.4435. PubMed PMID: 11082037.
  4. Fasano A. Regulation of intercellular tight junctions by zonula occludens toxin and its eukaryotic analogue zonulin. Ann N Y Acad Sci. 2000;915:214-22. doi: 10.1111/j.1749-6632.2000.tb05244.x. PubMed PMID: 11193578.
  5. Smecuol E, Sugai E, Niveloni S, Vazquez H, Pedreira S, Mazure R, et al. Permeability, zonulin production, and enteropathy in dermatitis herpetiformis. Clin Gastroenterol Hepatol. 2005;3:335-41. doi: 10.1016/s1542-3565(04)00778-5. PubMed PMID: 15822038.
  6. Sapone A, de Magistris L, Pietzak M, Clemente MG, Tripathi A, Cucca F, et al. Zonulin upregulation is associated with increased gut permeability in subjects with type 1 diabetes and their relatives. Diabetes. 2006;55:1443-9. doi: 10.2337/db05-1593. PubMed PMID: 16644703.
  7. Generoso M, De Rosa M, De Rosa R, De Magistris L, Secondulfo M, Fiandra R, et al. Cellobiose and lactulose coupled with mannitol and determined using ion-exchange chromatography with pulsed amperometric detection, are reliable probes for investigation of intestinal permeability. J Chromatogr B Analyt Technol Biomed Life Sci. 2003;783:349-57. doi: 10.1016/s1570-0232(02)00766-3. PubMed PMID: 12482477.
  8. Ohlsson B, Orho-Melander M, Nilsson PM. Higher Levels of Serum Zonulin May Rather Be Associated with Increased Risk of Obesity and Hyperlipidemia, Than with Gastrointestinal Symptoms or Disease Manifestations. Int J Mol Sci. 2017;18. doi: 10.3390/ijms18030582. PubMed PMID: 28282855; PubMed Central PMCID: PMCPMC5372598.
  9. Caviglia GP, Rosso C, Ribaldone DG, Dughera F, Fagoonee S, Astegiano M, et al. Physiopathology of intestinal barrier and the role of zonulin. Minerva biotecnologica. 2019;31:83-92. doi: 10.23736/S1120-4826.19.02554-0.
  10. Macura B, Kiecka A, Szczepanik M. Intestinal permeability disturbances: causes, diseases and therapy. Clin Exp Med. 2024;24:232. doi: 10.1007/s10238-024-01496-9. PubMed PMID: 39340718; PubMed Central PMCID: PMCPMC11438725.
  11. Fasano A. Zonulin, regulation of tight junctions, and autoimmune diseases. Ann N Y Acad Sci. 2012;1258:25-33. doi: 10.1111/j.1749-6632.2012.06538.x. PubMed PMID: 22731712; PubMed Central PMCID: PMCPMC3384703.
  12. Demir E, Ozkan H, Seckin KD, Sahtiyanci B, Demir B, Tabak O, et al. Plasma Zonulin Levels as a Non-Invasive Biomarker of Intestinal Permeability in Women with Gestational Diabetes Mellitus. Biomolecules. 2019;9. doi: 10.3390/biom9010024. PubMed PMID: 30641999; PubMed Central PMCID: PMCPMC6359541.
  13. Gamez-Macias PE, Felix-Soriano E, Samblas M, Sainz N, Moreno-Aliaga MJ, Gonzalez-Muniesa P. Intestinal Permeability, Gut Inflammation, and Gut Immune System Response Are Linked to Aging-Related Changes in Gut Microbiota Composition: A Study in Female Mice. J Gerontol A Biol Sci Med Sci. 2024;79. doi: 10.1093/gerona/glae045. PubMed PMID: 38364863; PubMed Central PMCID: PMCPMC10957128.
  14. Frati F, Salvatori C, Incorvaia C, Bellucci A, Di Cara G, Marcucci F, et al. The Role of the Microbiome in Asthma: The Gut(-)Lung Axis. Int J Mol Sci. 2018;20. doi: 10.3390/ijms20010123. PubMed PMID: 30598019; PubMed Central PMCID: PMCPMC6337651.
  15. Plovier H, Everard A, Druart C, Depommier C, Van Hul M, Geurts L, et al. A purified membrane protein from Akkermansia muciniphila or the pasteurized bacterium improves metabolism in obese and diabetic mice. Nat Med. 2017;23:107-13. doi: 10.1038/nm.4236. PubMed PMID: 27892954.
  16. Olsthoorn L, Vreeken D, Kiliaan AJ. Gut Microbiome, Inflammation, and Cerebrovascular Function: Link Between Obesity and Cognition. Front Neurosci. 2021;15:761456. doi: 10.3389/fnins.2021.761456. PubMed PMID: 34938153; PubMed Central PMCID: PMCPMC8685335.
  17. Moreno-Navarrete JM, Sabater M, Ortega F, Ricart W, Fernandez-Real JM. Circulating zonulin, a marker of intestinal permeability, is increased in association with obesity-associated insulin resistance. PLoS One. 2012;7:e37160. doi: 10.1371/journal.pone.0037160. PubMed PMID: 22629362; PubMed Central PMCID: PMCPMC3356365.
  18. Zak-Golab A, Kocelak P, Aptekorz M, Zientara M, Juszczyk L, Martirosian G, et al. Gut microbiota, microinflammation, metabolic profile, and zonulin concentration in obese and normal weight subjects. Int J Endocrinol. 2013;2013:674106. doi: 10.1155/2013/674106. PubMed PMID: 23970898; PubMed Central PMCID: PMCPMC3732644.
  19. Khaleghi S, Ju JM, Lamba A, Murray JA. The potential utility of tight junction regulation in celiac disease: focus on larazotide acetate. Therap Adv Gastroenterol. 2016;9:37-49. doi: 10.1177/1756283X15616576. PubMed PMID: 26770266; PubMed Central PMCID: PMCPMC4699279.
  20. American Diabetes A. Standards of medical care in diabetes--2008. Diabetes Care. 2008;31:S12-54. doi: 10.2337/dc08-S012. PubMed PMID: 18165335.
  21. Horvath A, Leber B, Schmerboeck B, Tawdrous M, Zettel G, Hartl A, et al. Randomised clinical trial: the effects of a multispecies probiotic vs. placebo on innate immune function, bacterial translocation and gut permeability in patients with cirrhosis. Aliment Pharmacol Ther. 2016;44:926-35. doi: 10.1111/apt.13788. PubMed PMID: 27593544; PubMed Central PMCID: PMCPMC5053220.
  22. Lamprecht M, Bogner S, Schippinger G, Steinbauer K, Fankhauser F, Hallstroem S, et al. Probiotic supplementation affects markers of intestinal barrier, oxidation, and inflammation in trained men; a randomized, double-blinded, placebo-controlled trial. J Int Soc Sports Nutr. 2012;9:45. doi: 10.1186/1550-2783-9-45. PubMed PMID: 22992437; PubMed Central PMCID: PMCPMC3465223.
  23. Serek P, Oleksy-Wawrzyniak M. The Effect of Bacterial Infections, Probiotics and Zonulin on Intestinal Barrier Integrity. Int J Mol Sci. 2021;22. doi: 10.3390/ijms222111359. PubMed PMID: 34768787; PubMed Central PMCID: PMCPMC8583036.
  24. Meng H, Ba Z, Lee Y, Peng J, Lin J, Fleming JA, et al. Consumption of Bifidobacterium animalis subsp. lactis BB-12 in yogurt reduced expression of TLR-2 on peripheral blood-derived monocytes and pro-inflammatory cytokine secretion in young adults. Eur J Nutr. 2017;56:649-61. doi: 10.1007/s00394-015-1109-5. PubMed PMID: 26621631.
  25. Ramezani Ahmadi A, Sadeghian M, Alipour M, Ahmadi Taheri S, Rahmani S, Abbasnezhad A. The Effects of Probiotic/Synbiotic on Serum Level of Zonulin as a Biomarker of Intestinal Permeability: A Systematic Review and Meta-Analysis. Iran J Public Health. 2020;49:1222-31. doi: 10.18502/ijph.v49i7.3575. PubMed PMID: 33083288; PubMed Central PMCID: PMCPMC7548501.
  26. Moher D, Liberati A, Tetzlaff J, Altman DG, Group P. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. BMJ. 2009;339:b2535. doi: 10.1136/bmj.b2535. PubMed PMID: 19622551; PubMed Central PMCID: PMCPMC2714657.
  27. Liu X, Wei X, Feng Y, Liu H, Tang J, Gao F, et al. Supplementation with Complex Dietary Fiber during Late Pregnancy and Lactation Can Improve Progeny Growth Performance by Regulating Maternal Antioxidant Status and Milk Quality. Antioxidants (Basel). 2023;13. doi: 10.3390/antiox13010022. PubMed PMID: 38275642; PubMed Central PMCID: PMCPMC10812556.
  28. Gargari G, Mantegazza G, Cremon C, Taverniti V, Valenza A, Barbaro MR, et al. Collinsella aerofaciens as a predictive marker of response to probiotic treatment in non-constipated irritable bowel syndrome. Gut Microbes. 2024;16:2298246. doi: 10.1080/19490976.2023.2298246. PubMed PMID: 38178601; PubMed Central PMCID: PMCPMC10773624.
  29. Rybak I, Haas KN, Dhaliwal SK, Burney WA, Pourang A, Sandhu SS, et al. Prospective Placebo-Controlled Assessment of Spore-Based Probiotic Supplementation on Sebum Production, Skin Barrier Function, and Acne. J Clin Med. 2023;12. doi: 10.3390/jcm12030895. PubMed PMID: 36769543; PubMed Central PMCID: PMCPMC9918080.
  30. Olveira G, Padial M, Hevilla F, Barril G, Blanca M, Climent E, et al. Could probiotics reduce depressive symptoms in malnourished hemodialysis patients? Renacare trial. Clinical Nutrition ESPEN. 2023;58:509. doi: 10.1016/j.clnesp.2023.09.250.
  31. Guiducci L, Cabiati M, Santocchi E, Prosperi M, Morales MA, Muratori F, et al. Expression of miRNAs in Pre-Schoolers with Autism Spectrum Disorders Compared with Typically Developing Peers and Its Effects after Probiotic Supplementation. J Clin Med. 2023;12. doi: 10.3390/jcm12227162. PubMed PMID: 38002774; PubMed Central PMCID: PMCPMC10672692.
  32. Haarman B, Ioannou M, Borkent J, Sommer IE. Personalized treatment with markers of intestinal inflammation, microbiome and permeability in bipolar disorder. Bipolar Disorders. 2022;24:37. doi: 10.1111/bdi.13234.
  33. Caviglia GP, Tucci A, Pellicano R, Fagoonee S, Rosso C, Abate ML, et al. Clinical Response and Changes of Cytokines and Zonulin Levels in Patients with Diarrhoea-Predominant Irritable Bowel Syndrome Treated with Bifidobacterium Longum ES1 for 8 or 12 Weeks: A Preliminary Report. J Clin Med. 2020;9. doi: 10.3390/jcm9082353. PubMed PMID: 32717980; PubMed Central PMCID: PMCPMC7464152.
  34. Lee IK, Kye B-H, Lee J-H, Park IJ, Oh H-K, Cho YB, et al. 944 – The Effects of Probiotics on Symptom and Surgical Outcome After Anterior Resection of Colon Cancer; Multicenter, Double-Blind, Randomized, Placebo-Controlled Trial (Postcare Study). Gastroenterology. 2019;156:1423. doi: 10.1016/S0016-5085(19)40610-0.
  35. Janczy A, Kochan Z, Małgorzewicz S. OR15: Does The Low-Calorie Diet and Probiotic Supplementation Influenced on Intestinal Barrier and Microbiome in Overweight and Obese Subjects? Clinical Nutrition. 2019;38:S10. doi: 10.1016/S0261-5614(19)32487-2.
  36. Horvath A, Durdevic M, Leber B, Schmerboeck B, Rainer F, Douschan P, et al. Multispecies probiotic enriches the microbiome with lactobacillus and lactococcus and reduces enterococcus abundance in patients with liver cirrhosis: Results of a randomized, doubleblind, placebo-controlled trial. United European Gastroenterology Journal. 2017;5:P1338. doi: 10.1177/2050640617725676. PubMed Central PMCID: PMCPMC7672678.
  37. Horvath A, Leber B, Schmerboeck B, Tawdrous M, Zettel G, Hartl A, et al. A multispecies probiotic enhances antimicrobial activity in cirrhosis: A randomized, double blind placebo-controlled study. Zeitschrift für Gastroenterologie. 2016;54:P84. doi: 10.1055/s-0036-1584062.
  38. Riviere AJ, Smith KS, Schaberg MN, Greene MW, Fruge AD. Plasma and fecal zonulin are not altered by a high green leafy vegetable dietary intervention: secondary analysis of a randomized control crossover trial. BMC Gastroenterol. 2022;22:184. doi: 10.1186/s12876-022-02248-3. PubMed PMID: 35413837; PubMed Central PMCID: PMCPMC9004007.
  39. Vuholm S, Nielsen DS, Iversen KN, Suhr J, Westermann P, Krych L, et al. Whole-Grain Rye and Wheat Affect Some Markers of Gut Health without Altering the Fecal Microbiota in Healthy Overweight Adults: A 6-Week Randomized Trial. J Nutr. 2017;147:2067-75. doi: 10.3945/jn.117.250647. PubMed PMID: 28954842.
  40. Kantah M, Catanzaro R, Kumar M, Jeong W, Marcellino M. Beneficial Gut Effect of a Symbiotic-Probiotic Regimen in Healthy Stressed Individuals: Effectiveness on Permeability, Microbiota and Detoxification Parameters. J Gastrointest Dig Syst. 2018;8:560.
  41. Townsend JR, Bender D, Vantrease WC, Sapp PA, Toy AM, Woods CA, et al. Effects of Probiotic (Bacillus subtilis DE111) Supplementation on Immune Function, Hormonal Status, and Physical Performance in Division I Baseball Players. Sports (Basel). 2018;6. doi: 10.3390/sports6030070. PubMed PMID: 30049931; PubMed Central PMCID: PMCPMC6162611.
  42. Cakir M, Aksel Isbilen A, Eyupoglu I, Sag E, Orem A, Mazlum Sen T, et al. Effects of long-term synbiotic supplementation in addition to lifestyle changes in children with obesity-related non-alcoholic fatty liver disease. Turk J Gastroenterol. 2017;28:377-83. doi: 10.5152/tjg.2017.17084. PubMed PMID: 28797988.
  43. Hiel S, Gianfrancesco MA, Rodriguez J, Portheault D, Leyrolle Q, Bindels LB, et al. Link between gut microbiota and health outcomes in inulin -treated obese patients: Lessons from the Food4Gut multicenter randomized placebo-controlled trial. Clin Nutr. 2020;39:3618-28. doi: 10.1016/j.clnu.2020.04.005. PubMed PMID: 32340903.
  44. Bloomer RJ, Butawan M, van der Merwe M, Keating FH. An Assessment of the Glyconutrient Ambrotose on Immunity, Gut Health, and Safety in Men and Women: A Placebo-Controlled, Double-Blind, Randomized Clinical Trial. Nutrients. 2020;12. doi: 10.3390/nu12061751. PubMed PMID: 32545396; PubMed Central PMCID: PMCPMC7353283.
  45. Ranaivo H, Zhang Z, Alligier M, Van Den Berghe L, Sothier M, Lambert-Porcheron S, et al. Chitin-glucan supplementation improved postprandial metabolism and altered gut microbiota in subjects at cardiometabolic risk in a randomized trial. Sci Rep. 2022;12:8830. doi: 10.1038/s41598-022-12920-z. PubMed PMID: 35614185; PubMed Central PMCID: PMCPMC9132890.
  46. Ramos CI, Armani RG, Canziani MEF, Dalboni MA, Dolenga CJR, Nakao LS, et al. Effect of prebiotic (fructooligosaccharide) on uremic toxins of chronic kidney disease patients: a randomized controlled trial. Nephrol Dial Transplant. 2019;34:1876-84. doi: 10.1093/ndt/gfy171. PubMed PMID: 29939302.
  47. Vaghef-Mehrabani E, Harouni R, Behrooz M, Ranjbar F, Asghari-Jafarabadi M, Ebrahimi-Mameghani M. Effects of inulin supplementation on inflammatory biomarkers and clinical symptoms of women with obesity and depression on a calorie-restricted diet: a randomised controlled clinical trial. Br J Nutr. 2023;129:1897-907. doi: 10.1017/S000711452200232X. PubMed PMID: 36059088.
  48. Krawczyk M, Maciejewska D, Ryterska K, Czerwinka-Rogowska M, Jamiol-Milc D, Skonieczna-Zydecka K, et al. Gut Permeability Might be Improved by Dietary Fiber in Individuals with Nonalcoholic Fatty Liver Disease (NAFLD) Undergoing Weight Reduction. Nutrients. 2018;10. doi: 10.3390/nu10111793. PubMed PMID: 30453660; PubMed Central PMCID: PMCPMC6266494.
  49. Drabinska N, Krupa-Kozak U, Jarocka-Cyrta E. Intestinal Permeability in Children with Celiac Disease after the Administration of Oligofructose-Enriched Inulin into a Gluten-Free Diet-Results of a Randomized, Placebo-Controlled, Pilot Trial. Nutrients. 2020;12. doi: 10.3390/nu12061736. PubMed PMID: 32531982; PubMed Central PMCID: PMCPMC7352250.
  50. Russo F, Linsalata M, Clemente C, Chiloiro M, Orlando A, Marconi E, et al. Inulin-enriched pasta improves intestinal permeability and modifies the circulating levels of zonulin and glucagon-like peptide 2 in healthy young volunteers. Nutr Res. 2012;32:940-6. doi: 10.1016/j.nutres.2012.09.010. PubMed PMID: 23244539.
  51. Czerwinska-Rogowska M, Skonieczna-Zydecka K, Kaseja K, Jakubczyk K, Palma J, Bott-Olejnik M, et al. Kitchen Diet vs. Industrial Diets-Impact on Intestinal Barrier Parameters among Stroke Patients. Int J Environ Res Public Health. 2022;19. doi: 10.3390/ijerph19106168. PubMed PMID: 35627704; PubMed Central PMCID: PMCPMC9141131.
  52. Neyrinck AM, Rodriguez J, Zhang Z, Seethaler B, Sanchez CR, Roumain M, et al. Prebiotic dietary fibre intervention improves fecal markers related to inflammation in obese patients: results from the Food4Gut randomized placebo-controlled trial. Eur J Nutr. 2021;60:3159-70. doi: 10.1007/s00394-021-02484-5. PubMed PMID: 33544206; PubMed Central PMCID: PMCPMC8354918.
  53. Lee DPS, Gan AX, Xia XJ, Toh KQX, Chan G, Jung S, et al. Regular Consumption of Biovalorized Okara-Containing Biscuit Improves Circulating Short-Chain Fatty Acids and Fecal Bile Acids Concentrations by Modulating the Gut Microbiome: A Randomized Controlled Crossover Trial. Mol Nutr Food Res. 2023;67:e2200756. doi: 10.1002/mnfr.202200756. PubMed PMID: 37118978.
  54. Liu Z, Li C, Huang M, Tong C, Zhang X, Wang L, et al. Positive regulatory effects of perioperative probiotic treatment on postoperative liver complications after colorectal liver metastases surgery: a double-center and double-blind randomized clinical trial. BMC Gastroenterol. 2015;15:34. doi: 10.1186/s12876-015-0260-z. PubMed PMID: 25881090; PubMed Central PMCID: PMCPMC4374379.
  55. Stenman LK, Lehtinen MJ, Meland N, Christensen JE, Yeung N, Saarinen MT, et al. Probiotic With or Without Fiber Controls Body Fat Mass, Associated With Serum Zonulin, in Overweight and Obese Adults-Randomized Controlled Trial. EBioMedicine. 2016;13:190-200. doi: 10.1016/j.ebiom.2016.10.036. PubMed PMID: 27810310; PubMed Central PMCID: PMCPMC5264483.
  56. de Roos NM, van Hemert S, Rovers JMP, Smits MG, Witteman BJM. The effects of a multispecies probiotic on migraine and markers of intestinal permeability-results of a randomized placebo-controlled study. Eur J Clin Nutr. 2017;71:1455-62. doi: 10.1038/ejcn.2017.57. PubMed PMID: 28537581.
  57. Liu ZH, Huang MJ, Zhang XW, Wang L, Huang NQ, Peng H, et al. The effects of perioperative probiotic treatment on serum zonulin concentration and subsequent postoperative infectious complications after colorectal cancer surgery: a double-center and double-blind randomized clinical trial. Am J Clin Nutr. 2013;97:117-26. doi: 10.3945/ajcn.112.040949. PubMed PMID: 23235200.
  58. Mokkala K, Pussinen P, Houttu N, Koivuniemi E, Vahlberg T, Laitinen K. The impact of probiotics and n-3 long-chain polyunsaturated fatty acids on intestinal permeability in pregnancy: a randomised clinical trial. Benef Microbes. 2018;9:199-208. doi: 10.3920/BM2017.0072. PubMed PMID: 29345158.
  59. Horvath A, Leber B, Feldbacher N, Tripolt N, Rainer F, Blesl A, et al. Effects of a multispecies synbiotic on glucose metabolism, lipid marker, gut microbiome composition, gut permeability, and quality of life in diabesity: a randomized, double-blind, placebo-controlled pilot study. Eur J Nutr. 2020;59:2969-83. doi: 10.1007/s00394-019-02135-w. PubMed PMID: 31729622; PubMed Central PMCID: PMCPMC7501130.
  60. Ghavami A, Khorvash F, Heidari Z, Khalesi S, Askari G. Effect of synbiotic supplementation on migraine characteristics and inflammatory biomarkers in women with migraine: Results of a randomized controlled trial. Pharmacol Res. 2021;169:105668. doi: 10.1016/j.phrs.2021.105668. PubMed PMID: 33989763.
  61. Wilms E, Gerritsen J, Smidt H, Besseling-van der Vaart I, Rijkers GT, Garcia Fuentes AR, et al. Effects of Supplementation of the Synbiotic Ecologic(R) 825/FOS P6 on Intestinal Barrier Function in Healthy Humans: A Randomized Controlled Trial. PLoS One. 2016;11:e0167775. doi: 10.1371/journal.pone.0167775. PubMed PMID: 27936169; PubMed Central PMCID: PMCPMC5147956.
  62. Petelin A, Sik Novak K, Hladnik M, Bandelj D, Baruca Arbeiter A, Kramberger K, et al. Helichrysum italicum (Roth) G. Don and Helichrysum arenarium (L.) Moench Infusion Consumption Affects the Inflammatory Status and the Composition of Human Gut Microbiota in Patients with Traits of Metabolic Syndrome: A Randomized Comparative Study. Foods. 2022;11. doi: 10.3390/foods11203277. PubMed PMID: 37431025; PubMed Central PMCID: PMCPMC9601527.
  63. Stadlbauer V, Leber B, Lemesch S, Trajanoski S, Bashir M, Horvath A, et al. Lactobacillus casei Shirota Supplementation Does Not Restore Gut Microbiota Composition and Gut Barrier in Metabolic Syndrome: A Randomized Pilot Study. PLoS One. 2015;10:e0141399. doi: 10.1371/journal.pone.0141399. PubMed PMID: 26509793; PubMed Central PMCID: PMCPMC4625062.
  64. Roman E, Nieto JC, Gely C, Vidal S, Pozuelo M, Poca M, et al. Effect of a Multistrain Probiotic on Cognitive Function and Risk of Falls in Patients With Cirrhosis: A Randomized Trial. Hepatol Commun. 2019;3:632-45. doi: 10.1002/hep4.1325. PubMed PMID: 31061952; PubMed Central PMCID: PMCPMC6492476.
  65. Axelrod CL, Brennan CJ, Cresci G, Paul D, Hull M, Fealy CE, et al. UCC118 supplementation reduces exercise-induced gastrointestinal permeability and remodels the gut microbiome in healthy humans. Physiol Rep. 2019;7:e14276. doi: 10.14814/phy2.14276. PubMed PMID: 31758610; PubMed Central PMCID: PMCPMC6874782.
  66. Horvath A, Durdevic M, Leber B, di Vora K, Rainer F, Krones E, et al. Changes in the Intestinal Microbiome during a Multispecies Probiotic Intervention in Compensated Cirrhosis. Nutrients. 2020;12. doi: 10.3390/nu12061874. PubMed PMID: 32585997; PubMed Central PMCID: PMCPMC7353185.
  67. Karim A, Muhammad T, Shahid Iqbal M, Qaisar R. A multistrain probiotic improves handgrip strength and functional capacity in patients with COPD: A randomized controlled trial. Arch Gerontol Geriatr. 2022;102:104721. doi: 10.1016/j.archger.2022.104721. PubMed PMID: 35567889.
  68. Karim A, Muhammad T, Shah I, Khan J, Qaisar R. A multistrain probiotic reduces sarcopenia by modulating Wnt signaling biomarkers in patients with chronic heart failure. J Cardiol. 2022;80:449-55. doi: 10.1016/j.jjcc.2022.06.006. PubMed PMID: 35750555.
  69. Ayob N, Muhammad Nawawi KN, Mohamad Nor MH, Raja Ali RA, Ahmad HF, Oon SF, et al. The Effects of Probiotics on Small Intestinal Microbiota Composition, Inflammatory Cytokines and Intestinal Permeability in Patients with Non-Alcoholic Fatty Liver Disease. Biomedicines. 2023;11. doi: 10.3390/biomedicines11020640. PubMed PMID: 36831176; PubMed Central PMCID: PMCPMC9953317.
  70. Qaisar R, Burki A, Karim A, Iqbal MS, Ahmad F. Probiotics Supplements Improve the Sarcopenia-Related Quality of Life in Older Adults with Age-Related Muscle Decline. Calcif Tissue Int. 2024;114:583-91. doi: 10.1007/s00223-024-01211-6. PubMed PMID: 38642090.
  71. Lennon S, Lackie T, Miltko A, Kearns ZC, Paquette MR, Bloomer RJ, et al. Safety and efficacy of a probiotic cocktail containing P. acidilactici and L. plantarum for gastrointestinal discomfort in endurance runners: randomized double-blinded crossover clinical trial. Appl Physiol Nutr Metab. 2024;49:890-903. doi: 10.1139/apnm-2023-0449. PubMed PMID: 38427981.
  72. Delzenne NM, Cani PD. Interaction between obesity and the gut microbiota: relevance in nutrition. Annu Rev Nutr. 2011;31:15-31. doi: 10.1146/annurev-nutr-072610-145146. PubMed PMID: 21568707.
  73. Delzenne NM, Neyrinck AM, Cani PD. Modulation of the gut microbiota by nutrients with prebiotic properties: consequences for host health in the context of obesity and metabolic syndrome. Microb Cell Fact. 2011;10:S10. doi: 10.1186/1475-2859-10-S1-S10. PubMed PMID: 21995448; PubMed Central PMCID: PMCPMC3231917.
  74. Delzenne NM, Cani PD, Everard A, Neyrinck AM, Bindels LB. Gut microorganisms as promising targets for the management of type 2 diabetes. Diabetologia. 2015;58:2206-17. doi: 10.1007/s00125-015-3712-7. PubMed PMID: 26224102.
  75. Delzenne NM, Rodriguez J, Olivares M, Neyrinck AM. Microbiome response to diet: focus on obesity and related diseases. Rev Endocr Metab Disord. 2020;21:369-80. doi: 10.1007/s11154-020-09572-7. PubMed PMID: 32691288.
  76. Amiri P, Arefhosseini S, Bakhshimoghaddam F, Jamshidi Gurvan H, Hosseini SA. Mechanistic insights into the pleiotropic effects of butyrate as a potential therapeutic agent on NAFLD management: A systematic review. Front Nutr. 2022;9:1037696. doi: 10.3389/fnut.2022.1037696. PubMed PMID: 36532559; PubMed Central PMCID: PMCPMC9755748.
  77. Chavez-Talavera O, Tailleux A, Lefebvre P, Staels B. Bile Acid Control of Metabolism and Inflammation in Obesity, Type 2 Diabetes, Dyslipidemia, and Nonalcoholic Fatty Liver Disease. Gastroenterology. 2017;152:1679-94. doi: 10.1053/j.gastro.2017.01.055. PubMed PMID: 28214524.
  78. Hu FB, Rimm E, Smith-Warner SA, Feskanich D, Stampfer MJ, Ascherio A, et al. Reproducibility and validity of dietary patterns assessed with a food-frequency questionnaire. Am J Clin Nutr. 1999;69:243-9. doi: 10.1093/ajcn/69.2.243. PubMed PMID: 9989687.
  79. Leech B, Schloss J, Steel A. Association between increased intestinal permeability and disease: A systematic review. Advances in Integrative Medicine. 2019;6:23-34. doi: 10.1016/j.aimed.2018.08.003.
  80. Ohlsson B, Roth B, Larsson E, Hoglund P. Calprotectin in serum and zonulin in serum and feces are elevated after introduction of a diet with lower carbohydrate content and higher fiber, fat and protein contents. Biomed Rep. 2017;6:411-22. doi: 10.3892/br.2017.865. PubMed PMID: 28413639; PubMed Central PMCID: PMCPMC5374938.
  81. Ohlsson B. An Okinawan-based Nordic diet improves glucose and lipid metabolism in health and type 2 diabetes, in alignment with changes in the endocrine profile, whereas zonulin levels are elevated. Exp Ther Med. 2019;17:2883-93. doi: 10.3892/etm.2019.7303. PubMed PMID: 30936958; PubMed Central PMCID: PMCPMC6434283.
  82. Qi Y, Goel R, Kim S, Richards EM, Carter CS, Pepine CJ, et al. Intestinal Permeability Biomarker Zonulin is Elevated in Healthy Aging. J Am Med Dir Assoc. 2017;18:810. doi: 10.1016/j.jamda.2017.05.018. PubMed PMID: 28676292; PubMed Central PMCID: PMCPMC5581307.
  83. Guarner F. Studies with inulin-type fructans on intestinal infections, permeability, and inflammation. J Nutr. 2007;137:2568S-71S. doi: 10.1093/jn/137.11.2568S. PubMed PMID: 17951504.
  84. Akbari P, Fink-Gremmels J, Willems R, Difilippo E, Schols HA, Schoterman MHC, et al. Characterizing microbiota-independent effects of oligosaccharides on intestinal epithelial cells: insight into the role of structure and size : Structure-activity relationships of non-digestible oligosaccharides. Eur J Nutr. 2017;56:1919-30. doi: 10.1007/s00394-016-1234-9. PubMed PMID: 27295033; PubMed Central PMCID: PMCPMC5534205.
  85. Pham VT, Seifert N, Richard N, Raederstorff D, Steinert RE, Prudence K, et al. The effects of fermentation products of prebiotic fibres on gut barrier and immune functions in vitro. PeerJ. 2018;6:e5288. doi: 10.7717/peerj.5288. PubMed PMID: 30128177; PubMed Central PMCID: PMCPMC6089210.
  86. Hansen CHF, Larsen CS, Petersson HO, Zachariassen LF, Vegge A, Lauridsen C, et al. Targeting gut microbiota and barrier function with prebiotics to alleviate autoimmune manifestations in NOD mice. Diabetologia. 2019;62:1689-700. doi: 10.1007/s00125-019-4910-5. PubMed PMID: 31139852.
  87. Rodriguez J, Neyrinck AM, Zhang Z, Seethaler B, Nazare JA, Robles Sanchez C, et al. Metabolite profiling reveals the interaction of chitin-glucan with the gut microbiota. Gut Microbes. 2020;12:1810530. doi: 10.1080/19490976.2020.1810530. PubMed PMID: 32893709; PubMed Central PMCID: PMCPMC7524357.
  88. Jimenez-Escrig A, Tenorio MD, Espinosa-Martos I, Ruperez P. Health-promoting effects of a dietary fiber concentrate from the soybean byproduct okara in rats. J Agric Food Chem. 2008;56:7495-501. doi: 10.1021/jf800792y. PubMed PMID: 18636739.
  89. Yogo T, Ohashi Kunihiko Terakado Y, Harada Y, Nezu Y, Hara Y, Tagawa M, et al. Influence of dried okara-tempeh on the composition and metabolites of fecal microbiota in dogs. International Journal of Applied Research inVeterinary Medicine. 2011;9:176.
  90. Muller M, Hermes GDA, Canfora EE, Smidt H, Masclee AAM, Zoetendal EG, et al. Distal colonic transit is linked to gut microbiota diversity and microbial fermentation in humans with slow colonic transit. Am J Physiol Gastrointest Liver Physiol. 2020;318:G361-G9. doi: 10.1152/ajpgi.00283.2019. PubMed PMID: 31869241.
  91. Frolich W, Aman P, Tetens I. Whole grain foods and health - a Scandinavian perspective. Food Nutr Res. 2013;57. doi: 10.3402/fnr.v57i0.18503. PubMed PMID: 23411562; PubMed Central PMCID: PMCPMC3572214.
  92. Costabile A, Klinder A, Fava F, Napolitano A, Fogliano V, Leonard C, et al. Whole-grain wheat breakfast cereal has a prebiotic effect on the human gut microbiota: a double-blind, placebo-controlled, crossover study. Br J Nutr. 2008;99:110-20. doi: 10.1017/S0007114507793923. PubMed PMID: 17761020.
  93. Ross AB, Bruce SJ, Blondel-Lubrano A, Oguey-Araymon S, Beaumont M, Bourgeois A, et al. A whole-grain cereal-rich diet increases plasma betaine, and tends to decrease total and LDL-cholesterol compared with a refined-grain diet in healthy subjects. Br J Nutr. 2011;105:1492-502. doi: 10.1017/S0007114510005209. PubMed PMID: 21272402.
  94. Kelly BJ, Gross R, Bittinger K, Sherrill-Mix S, Lewis JD, Collman RG, et al. Power and sample-size estimation for microbiome studies using pairwise distances and PERMANOVA. Bioinformatics. 2015;31:2461-8. doi: 10.1093/bioinformatics/btv183. PubMed PMID: 25819674; PubMed Central PMCID: PMCPMC4514928.
  95. Gråsten SM, Juntunen KS, Mättö J, Mykkänen OT, El-Nezami H, Adlercreutz H, et al. High-fiber rye bread improves bowel function in postmenopausal women but does not cause other putatively positive changes in the metabolic activity of intestinal microbiota. Nutrition Research. 2007;27:454-61. doi: 10.1016/j.nutres.2007.05.010.
  96. Holma R, Hongisto SM, Saxelin M, Korpela R. Constipation is relieved more by rye bread than wheat bread or laxatives without increased adverse gastrointestinal effects. J Nutr. 2010;140:534-41. doi: 10.3945/jn.109.118570. PubMed PMID: 20089780.
  97. McIntosh GH, Noakes M, Royle PJ, Foster PR. Whole-grain rye and wheat foods and markers of bowel health in overweight middle-aged men. Am J Clin Nutr. 2003;77:967-74. doi: 10.1093/ajcn/77.4.967. PubMed PMID: 12663299.
  98. Ampatzoglou A, Atwal KK, Maidens CM, Williams CL, Ross AB, Thielecke F, et al. Increased whole grain consumption does not affect blood biochemistry, body composition, or gut microbiology in healthy, low-habitual whole grain consumers. J Nutr. 2015;145:215-21. doi: 10.3945/jn.114.202176. PubMed PMID: 25644340.
  99. Macfarlane GT, Macfarlane S. Bacteria, colonic fermentation, and gastrointestinal health. J AOAC Int. 2012;95:50-60. doi: 10.5740/jaoacint.sge_macfarlane. PubMed PMID: 22468341.
  100. Wong JM, de Souza R, Kendall CW, Emam A, Jenkins DJ. Colonic health: fermentation and short chain fatty acids. J Clin Gastroenterol. 2006;40:235-43. doi: 10.1097/00004836-200603000-00015. PubMed PMID: 16633129.
  101. Suhr J, Vuholm S, Iversen KN, Landberg R, Kristensen M. Wholegrain rye, but not wholegrain wheat, lowers body weight and fat mass compared with refined wheat: a 6-week randomized study. Eur J Clin Nutr. 2017;71:959-67. doi: 10.1038/ejcn.2017.12. PubMed PMID: 28327566.
  102. Alsaffar AA. Effect of food processing on the resistant starch content of cereals and cereal products – a review. International Journal of Food Science and Technology. 2011;46:455-62. doi: 10.1111/j.1365-2621.2010.02529.x.
  103. Lewis SJ, Heaton KW. Increasing butyrate concentration in the distal colon by accelerating intestinal transit. Gut. 1997;41:245-51. doi: 10.1136/gut.41.2.245. PubMed PMID: 9301506; PubMed Central PMCID: PMCPMC1891451.
  104. Slavin J. Whole grains and digestive health. Cereal Chemistry. 2010;87:292-6.
  105. Scheinin T, Butler DM, Salway F, Scallon B, Feldmann M. Validation of the interleukin-10 knockout mouse model of colitis: antitumour necrosis factor-antibodies suppress the progression of colitis. Clin Exp Immunol. 2003;133:38-43. doi: 10.1046/j.1365-2249.2003.02193.x. PubMed PMID: 12823276; PubMed Central PMCID: PMCPMC1808754.
  106. Atarashi K, Tanoue T, Oshima K, Suda W, Nagano Y, Nishikawa H, et al. Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota. Nature. 2013;500:232-6. doi: 10.1038/nature12331. PubMed PMID: 23842501.
  107. Gullon B, Gullon P, Tavaria F, Alonso JL, Pintado M. In vitro assessment of the prebiotic potential of Aloe vera mucilage and its impact on the human microbiota. Food Funct. 2015;6:525-31. doi: 10.1039/c4fo00857j. PubMed PMID: 25504136.
  108. Quezada MP, Salinas C, Gotteland M, Cardemil L. Acemannan and Fructans from Aloe vera (Aloe barbadensis Miller) Plants as Novel Prebiotics. J Agric Food Chem. 2017;65:10029-39. doi: 10.1021/acs.jafc.7b04100. PubMed PMID: 29072072.
  109. Fordjour L, D’Souza A, Cai C, Ahmad A, Valencia G, Kumar D, et al. Comparative effects of probiotics, prebiotics, and synbiotics on growth factors in the large bowel in a rat model of formula-induced bowel inflammation. J Pediatr Gastroenterol Nutr. 2010;51:507-13. doi: 10.1097/MPG.0b013e3181df5ff2. PubMed PMID: 20683203.
  110. Fukunaga T, Sasaki M, Araki Y, Okamoto T, Yasuoka T, Tsujikawa T, et al. Effects of the soluble fibre pectin on intestinal cell proliferation, fecal short chain fatty acid production and microbial population. Digestion. 2003;67:42-9. doi: 10.1159/000069705. PubMed PMID: 12743440.
  111. Farhangi MA, Javid AZ, Sarmadi B, Karimi P, Dehghan P. A randomized controlled trial on the efficacy of resistant dextrin, as functional food, in women with type 2 diabetes: Targeting the hypothalamic-pituitary-adrenal axis and immune system. Clin Nutr. 2018;37:1216-23. doi: 10.1016/j.clnu.2017.06.005. PubMed PMID: 28669666.
  112. Dehghan P, Pourghassem Gargari B, Asghari Jafar-abadi M. Oligofructose-enriched inulin improves some inflammatory markers and metabolic endotoxemia in women with type 2 diabetes mellitus: a randomized controlled clinical trial. Nutrition. 2014;30:418-23. doi: 10.1016/j.nut.2013.09.005. PubMed PMID: 24332524.
  113. Murray KA, Hoad CL, Garratt J, Kaviani M, Marciani L, Smith JK, et al. A pilot study of visceral fat and its association with adipokines, stool calprotectin and symptoms in patients with diverticulosis. PLoS One. 2019;14:e0216528. doi: 10.1371/journal.pone.0216528. PubMed PMID: 31067253; PubMed Central PMCID: PMCPMC6505945.
  114. Del Piano M, Balzarini M, Carmagnola S, Pagliarulo M, Tari R, Nicola S, et al. Assessment of the capability of a gelling complex made of tara gum and the exopolysaccharides produced by the microorganism Streptococcus thermophilus ST10 to prospectively restore the gut physiological barrier: a pilot study. J Clin Gastroenterol. 2014;48:S56-61. doi: 10.1097/MCG.0000000000000254. PubMed PMID: 25291130.
  115. Ten Bruggencate SJ, Bovee-Oudenhoven IM, Lettink-Wissink ML, Katan MB, van der Meer R. Dietary fructooligosaccharides affect intestinal barrier function in healthy men. J Nutr. 2006;136:70-4. doi: 10.1093/jn/136.1.70. PubMed PMID: 16365061.
  116. Zheng Y, Zhang Z, Tang P, Wu Y, Zhang A, Li D, et al. Probiotics fortify intestinal barrier function: a systematic review and meta-analysis of randomized trials. Front Immunol. 2023;14:1143548. doi: 10.3389/fimmu.2023.1143548. PubMed PMID: 37168869; PubMed Central PMCID: PMCPMC10165082.
  117. Wells JM, Rossi O, Meijerink M, van Baarlen P. Epithelial crosstalk at the microbiota-mucosal interface. Proc Natl Acad Sci U S A. 2011;108 4607-14. doi: 10.1073/pnas.1000092107. PubMed PMID: 20826446; PubMed Central PMCID: PMCPMC3063605.
  118. Cario E, Gerken G, Podolsky DK. Toll-like receptor 2 controls mucosal inflammation by regulating epithelial barrier function. Gastroenterology. 2007;132:1359-74. doi: 10.1053/j.gastro.2007.02.056. PubMed PMID: 17408640.
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