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Maghsoumi-Norouzabad, Leila, Bagherzadeh-Karimi, Alireza, Aliakbari Majd, Shabnam, Hosseini, Leila, Shahi, Fatemeh. (1404). The Effects of Prebiotic Dietary Fibers, Probiotics, and Synbiotics on Gut Permeability and Immunity: A Systematic Review. سامانه مدیریت نشریات علمی, (), -. doi: 10.30476/ijms.2024.102363.3525
Leila Maghsoumi-Norouzabad; Alireza Bagherzadeh-Karimi; Shabnam Aliakbari Majd; Leila Hosseini; Fatemeh Shahi. "The Effects of Prebiotic Dietary Fibers, Probiotics, and Synbiotics on Gut Permeability and Immunity: A Systematic Review". سامانه مدیریت نشریات علمی, , , 1404, -. doi: 10.30476/ijms.2024.102363.3525
Maghsoumi-Norouzabad, Leila, Bagherzadeh-Karimi, Alireza, Aliakbari Majd, Shabnam, Hosseini, Leila, Shahi, Fatemeh. (1404). 'The Effects of Prebiotic Dietary Fibers, Probiotics, and Synbiotics on Gut Permeability and Immunity: A Systematic Review', سامانه مدیریت نشریات علمی, (), pp. -. doi: 10.30476/ijms.2024.102363.3525
Maghsoumi-Norouzabad, Leila, Bagherzadeh-Karimi, Alireza, Aliakbari Majd, Shabnam, Hosseini, Leila, Shahi, Fatemeh. The Effects of Prebiotic Dietary Fibers, Probiotics, and Synbiotics on Gut Permeability and Immunity: A Systematic Review. سامانه مدیریت نشریات علمی, 1404; (): -. doi: 10.30476/ijms.2024.102363.3525

The Effects of Prebiotic Dietary Fibers, Probiotics, and Synbiotics on Gut Permeability and Immunity: A Systematic Review

Iranian Journal of Medical Sciences
مقالات آماده انتشار، اصلاح شده برای چاپ، انتشار آنلاین از تاریخ 08 مرداد 1404    اصل مقاله (992.02 K)
نوع مقاله: Review Article
شناسه دیجیتال (DOI): 10.30476/ijms.2024.102363.3525
نویسندگان
Leila Maghsoumi-Norouzabad* 1، 2؛ Alireza Bagherzadeh-Karimi2، 3؛ Shabnam Aliakbari Majd4؛ Leila Hosseini5؛ Fatemeh Shahi6
1Traditional Medicine and Hydrotherapy Research Center, Ardabil University of Medical Sciences, Ardabil, Iran
2Research Center for Integrative Medicine in Aging, Aging Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran
3Department of Persian Medicine, School of Traditional Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
4Food and Drug Administration, Saveh University of Medical Sciences, Saveh, Iran
5Research Center of Psychiatry and Behavioral Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
6Infectious and Tropical Diseases Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
چکیده
Background: Modulation of intestinal barrier, which function through zonulin pathway downregulation, represents a promising therapeutic strategy for chronic diseases. This systematic review aimed to evaluate the effects of prebiotic dietary fibers, probiotics, and synbiotics on intestinal permeability and immunity. 
Methods: A systematic literature search of the EMBASE, PubMed, Web of Science, and Scopus electronic databases was conducted from database inception up to May 2024, supplemented by manual reference list searches. Included studies met the following criteria: (a) English language publications; (b) clinical trials; (c) investigated each factor of serum or fecal zonulin levels, serum or fecal calprotectin, glucagon-likepeptide-2 (GLP-2), short chain fatty acids (SCFAs), long chain fatty acids (LCFAs), fecal bile acid (BA), LPS-binding protein (LBP), lipopolysaccharide (LPS), intestinal microbiota composition, or inflammatory factors such as interleukin 6 (IL-6) and high-sensitivity C-reactive protein (hs-CRP); (d) supplemented prebiotic dietary fibers, probiotics, or symbiotics. Studies were excluded if they contained insufficient data or involved supplementation alongside other interventions. The study quality and risk of bias were assessed using Jadad’s Score.
Results: A total of 36 studies were included in this review. Of these, 14 articles (n=580 participants) evaluated the effect of dietary prebiotics, 18 articles (n=1502 participants) evaluated the effect of probiotics, and six articles (n=517 participants) examined the effect of synbiotics on intestinal health and immunity markers. According to the evidence presented in this study, prebiotic whole foods or food enriched with prebiotics, probiotics, and synbiotics might have favorable effects on the serum levels of zonulin as a measure of intestinal permeability. The effects on GLP-2, gut microbiota, and their metabolites (e.g., LCFAs/SCFAs and BA) were contradictory and inconclusive. Some studies indicated increased levels of Bifidobacteria and SCFA with prebiotic supplementation or prebiotics-enriched food products. Fecal calprotectin (as an important marker of the local gut inflammation), tumor necrosis factor-α (TNF-α), and hs-CRP were unaffected in most studies. 
Conclusion: The lack of consistent replication across studies made it difficult to draw definitive conclusions about the effects of prebiotics, probiotics, and synbiotics on gut-related health and immunity. Therefore, further evidence is required before definitive recommendations can be established. 

تازه های تحقیق

Leila Maghsoumi-Norouzabad (Google Scholar)

کلیدواژه‌ها
Probiotic؛ Synbiotic؛ Intestinal barrier function؛ Inflammation mediators؛ Zonulin
سایر فایل های مرتبط با مقاله
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