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Nazari, Seyedeh Elnaz, Ghorbani, Elnaz, Al-Asady, Abdulridha Mohammed, Sayyed-Hosseinian, Sayyed-Hadi, Rahmani, Farzad, Vahedi, Ehsan, Avan, Amir, Askarnia-Faal, Mohammad-Mostafa, Naimi, Hamideh, Khazaei, Majid, Hassanian, Seyed Mahdi. (1404). Anti-Fibrotic Effect of Tacrolimus on Preventing Adhesion after Achilles Tendon Surgery in a Murine Model. سامانه مدیریت نشریات علمی, (), -. doi: 10.30476/ijms.2025.102711.3587
Seyedeh Elnaz Nazari; Elnaz Ghorbani; Abdulridha Mohammed Al-Asady; Sayyed-Hadi Sayyed-Hosseinian; Farzad Rahmani; Ehsan Vahedi; Amir Avan; Mohammad-Mostafa Askarnia-Faal; Hamideh Naimi; Majid Khazaei; Seyed Mahdi Hassanian. "Anti-Fibrotic Effect of Tacrolimus on Preventing Adhesion after Achilles Tendon Surgery in a Murine Model". سامانه مدیریت نشریات علمی, , , 1404, -. doi: 10.30476/ijms.2025.102711.3587
Nazari, Seyedeh Elnaz, Ghorbani, Elnaz, Al-Asady, Abdulridha Mohammed, Sayyed-Hosseinian, Sayyed-Hadi, Rahmani, Farzad, Vahedi, Ehsan, Avan, Amir, Askarnia-Faal, Mohammad-Mostafa, Naimi, Hamideh, Khazaei, Majid, Hassanian, Seyed Mahdi. (1404). 'Anti-Fibrotic Effect of Tacrolimus on Preventing Adhesion after Achilles Tendon Surgery in a Murine Model', سامانه مدیریت نشریات علمی, (), pp. -. doi: 10.30476/ijms.2025.102711.3587
Nazari, Seyedeh Elnaz, Ghorbani, Elnaz, Al-Asady, Abdulridha Mohammed, Sayyed-Hosseinian, Sayyed-Hadi, Rahmani, Farzad, Vahedi, Ehsan, Avan, Amir, Askarnia-Faal, Mohammad-Mostafa, Naimi, Hamideh, Khazaei, Majid, Hassanian, Seyed Mahdi. Anti-Fibrotic Effect of Tacrolimus on Preventing Adhesion after Achilles Tendon Surgery in a Murine Model. سامانه مدیریت نشریات علمی, 1404; (): -. doi: 10.30476/ijms.2025.102711.3587

Anti-Fibrotic Effect of Tacrolimus on Preventing Adhesion after Achilles Tendon Surgery in a Murine Model

Iranian Journal of Medical Sciences
مقالات آماده انتشار، اصلاح شده برای چاپ، انتشار آنلاین از تاریخ 29 تیر 1404    اصل مقاله (1.66 M)
نوع مقاله: Original Article(s)
شناسه دیجیتال (DOI): 10.30476/ijms.2025.102711.3587
نویسندگان
Seyedeh Elnaz Nazari1؛ Elnaz Ghorbani2؛ Abdulridha Mohammed Al-Asady3، 4؛ Sayyed-Hadi Sayyed-Hosseinian5؛ Farzad Rahmani6، 7؛ Ehsan Vahedi5؛ Amir Avan7، 8؛ Mohammad-Mostafa Askarnia-Faal9؛ Hamideh Naimi9؛ Majid Khazaei* 1، 7؛ Seyed Mahdi Hassanian7، 9
1Department of Medical Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
2Department of Medical Microbiology and Virology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
3Department of Medical Sciences, School of Nursing, University of Warith Al-Anbiyaa, Iraq
4Department of Pharmacology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
5Orthopedic Research Center, Shahid Kamyab Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
6Kashmar School of Nursing, Mashhad University of Medical Sciences, Mashhad, Iran
7Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
8Department of Human Genetics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
9Department of Clinical Biochemistry, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
چکیده
Background: Peritendinous adhesion as a common post-surgical complication usually occurs as a result of a large portion of sports and hard job-related injuries. This study aims to evaluate the repurposed potential of the immunosuppressive approved drug, tacrolimus, in decreasing adhesion band formation post-Achilles tendon surgeries in an animal model.
Methods: Rats were randomly assigned to four groups: control, sham with surgical intervention but no adhesion, positive control group with surgical transection and adhesion received no treatment, tacrolimus group was the same as the positive control group except that rats were treated with 2 mg/Kg/day tacrolimus orally for 21 days. The anti-inflammatory and fibrinolytic properties of oral tacrolimus treatment in attenuating the formation of adhesion bands were analyzed by One-way ANOVA or the Kruskal-Wallis test.
Results: Tacrolimus decreased the length (P=0.001), density (P=0.001), grading (P=0.023), severity (P=0.001), and thickness (P=0.008) of post-surgical adhesion bands compared to the untreated group. Histopathological changes and recruitment of inflammatory cells to the tendon tissue sections were attenuated in the tacrolimus-treated group (P=0.001) in comparison with the positive control group. Compared to the untreated group, tacrolimus treatment decreased the expression of IL-1β (P=0.059) in the tendon tissue, but the difference was not statistically significant. Moreover, tacrolimus elicited anti-fibrotic responses by reducing the expression of tissue growth factor-β (TGF-β) in the tendon and inhibiting collagen deposition, fibrosis quantity (P=0.001), fibrosis grading (P=0.001), and total fibrosis scores (P=0.001), as visualized by Masson’s trichrome staining.
Conclusion: These results support the protective properties of tacrolimus in decreasing post-operative adhesion band formation in the animal model.

تازه های تحقیق

Seyedeh Elnaz Nazari (Google Scholar)

Elnaz Ghorbani (Google Scholar)

Majid Khazaei (Google Scholar)

کلیدواژه‌ها
Tacrolimus؛ Fibrosis ● Inflammation
مراجع
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آمار
تعداد مشاهده مقاله: 13
تعداد دریافت فایل اصل مقاله: 3


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