LinkedIn

 آمار

تعداد نشریات20
تعداد شماره‌ها1,206
تعداد مقالات10,987
تعداد مشاهده مقاله74,178,880
تعداد دریافت فایل اصل مقاله52,231,562
Eghbali, Fateme, Owliaey, Hamid, Shirani, Soheila, Fatahi Asl, Fatemeh, Hosseinzadeh, Reza, Deravi, Niloofar, Ghasemirad, Hamidreza, Shariatpanahi, Marjan, Farajidana, Hoorvash. (1404). Rhabdomyolysis in Patients with Drug or Chemical Poisoning: Clinical Investigation and Implications. سامانه مدیریت نشریات علمی, 50(7), 455-463. doi: 10.30476/ijms.2024.103681.3700
Fateme Eghbali; Hamid Owliaey; Soheila Shirani; Fatemeh Fatahi Asl; Reza Hosseinzadeh; Niloofar Deravi; Hamidreza Ghasemirad; Marjan Shariatpanahi; Hoorvash Farajidana. "Rhabdomyolysis in Patients with Drug or Chemical Poisoning: Clinical Investigation and Implications". سامانه مدیریت نشریات علمی, 50, 7, 1404, 455-463. doi: 10.30476/ijms.2024.103681.3700
Eghbali, Fateme, Owliaey, Hamid, Shirani, Soheila, Fatahi Asl, Fatemeh, Hosseinzadeh, Reza, Deravi, Niloofar, Ghasemirad, Hamidreza, Shariatpanahi, Marjan, Farajidana, Hoorvash. (1404). 'Rhabdomyolysis in Patients with Drug or Chemical Poisoning: Clinical Investigation and Implications', سامانه مدیریت نشریات علمی, 50(7), pp. 455-463. doi: 10.30476/ijms.2024.103681.3700
Eghbali, Fateme, Owliaey, Hamid, Shirani, Soheila, Fatahi Asl, Fatemeh, Hosseinzadeh, Reza, Deravi, Niloofar, Ghasemirad, Hamidreza, Shariatpanahi, Marjan, Farajidana, Hoorvash. Rhabdomyolysis in Patients with Drug or Chemical Poisoning: Clinical Investigation and Implications. سامانه مدیریت نشریات علمی, 1404; 50(7): 455-463. doi: 10.30476/ijms.2024.103681.3700

Rhabdomyolysis in Patients with Drug or Chemical Poisoning: Clinical Investigation and Implications

Iranian Journal of Medical Sciences
مقاله 3، دوره 50، شماره 7، مهر 2025، صفحه 455-463    اصل مقاله (372.49 K)
نوع مقاله: Original Article(s)
شناسه دیجیتال (DOI): 10.30476/ijms.2024.103681.3700
نویسندگان
Fateme Eghbali1؛ Hamid Owliaey* 2؛ Soheila Shirani1؛ Fatemeh Fatahi Asl1؛ Reza Hosseinzadeh3؛ Niloofar Deravi4؛ Hamidreza Ghasemirad5؛ Marjan Shariatpanahi6؛ Hoorvash Farajidana7
1Department of Medical Sciences, Yazd Branch, Islamic Azad University, Yazd, Iran
2Department of Forensic Medicine and Clinical Toxicology, Yazd Branch, Islamic Azad University, Yazd, Iran
3Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
4Student Research Committee, Shahid Beheshti University of Medical Sciences, Tehran, Iran
5Student Research Committee, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
6Department of Pharmacology and Toxicology, School of Pharmacy, Iran University of Medical Sciences, Tehran, Iran
7Clinical Toxicology, Kosar Educational and Medical Center, Alborz University of Medical Sciences, Karaj, Iran
چکیده
Background: Given that poisoning patterns vary by region and no comprehensive data exist on chemical/drug-induced rhabdomyolysis in Yazd province (Iran), this investigation was conducted to assess rhabdomyolysis incidence among patients with drug or chemical poisoning.
Methods: This descriptive cross-sectional study was conducted on all patients with chemical or drug poisoning in Shah Vali (Yazd) and Shahid Beheshti (Taft) Hospitals,  Iran, from March 2015 to 2020. All data were extracted from medical records. 
Results: Among 7800 patients with poisoning, 788 individuals (10.1%) were diagnosed with rhabdomyolysis. The predominant drug poisoning agents causing rhabdomyolysis were methadone, with 327 cases (41.5%), and benzodiazepines, with 80 cases (10.1%). The most common chemical poisoning agent was lead, occurring in 18 cases (2.28%). Acute kidney injury (AKI) requiring dialysis and death occurred in 96 (12.2%) and 55 (7%) patients, respectively. Methadone was associated with the highest frequencies of death and AKI requiring dialysis, accounting for 23 (41.8%) and 41 (42.7%) cases, respectively. A significant relationship was found between death and AKI requiring dialysis (P=0.002).  
Conclusion: The frequency of rhabdomyolysis was approximately 10%, with a 7% mortality rate among affected patients. Rhabdomyolysis was more frequently associated with drug poisoning than chemical poisoning, with methadone and benzodiazepines being the most frequently causative agents. Notably, methadone poisoning was associated with significantly higher rates of both AKI requiring dialysis and mortality. Moreover, AKI necessitating dialysis was identified as a significant predictor of mortality in these patients.

تازه های تحقیق

Fateme Eghbali (Google Scholar)

Hamid Owliaey (Google Scholar)

کلیدواژه‌ها
Drug؛ Poisoning؛ Rhabdomyolysis
مراجع
  1. Mousavi S, Taghaddosinejad F, Talaee H, Zare GA, Sadeghi M, Rajaee P, et al. Clinical and laboratory evaluation of rhabdomyolysis in 165 patients with severe acute poisonings. Journal of Birjand University of Medical Sciences. 2010;17:136-42.
  2. Yang J, Zhou J, Wang X, Wang S, Tang Y, Yang L. Risk factors for severe acute kidney injury among patients with rhabdomyolysis. BMC Nephrol. 2020;21:498. doi: 10.1186/s12882-020-02104-0. PubMed PMID: 33225908; PubMed Central PMCID: PMCPMC7681970.
  3. Giannoglou GD, Chatzizisis YS, Misirli G. The syndrome of rhabdomyolysis: Pathophysiology and diagnosis. Eur J Intern Med. 2007;18:90-100. doi: 10.1016/j.ejim.2006.09.020. PubMed PMID: 17338959.
  4. Gonçalves LCO, Paulino E, Ferreira L, Matta N, Silva P, Lopes J, et al. Rhabdomyolysis a narrative review of the main causal factors and physiological outcomes. World Journal of Pharmacy and Pharmaceutical Sciences. 2020;9:225-35.
  5. Carneiro A, Viana-Gomes D, Macedo-da-Silva J, Lima GHO, Mitri S, Alves SR, et al. Risk factors and future directions for preventing and diagnosing exertional rhabdomyolysis. Neuromuscul Disord. 2021;31:583-95. doi: 10.1016/j.nmd.2021.04.007. PubMed PMID: 34193371.
  6. Kodadek L, Carmichael Ii SP, Seshadri A, Pathak A, Hoth J, Appelbaum R, et al. Rhabdomyolysis: an American Association for the Surgery of Trauma Critical Care Committee Clinical Consensus Document. Trauma Surg Acute Care Open. 2022;7:e000836. doi: 10.1136/tsaco-2021-000836. PubMed PMID: 35136842; PubMed Central PMCID: PMCPMC8804685.
  7. Rogliano PF, Voicu S, Labat L, Deye N, Malissin I, Laplanche JL, et al. Acute Poisoning with Rhabdomyolysis in the Intensive Care Unit: Risk Factors for Acute Kidney Injury and Renal Replacement Therapy Requirement. Toxics. 2020;8. doi: 10.3390/toxics8040079. PubMed PMID: 32998294; PubMed Central PMCID: PMCPMC7711436.
  8. Bosch X, Poch E, Grau JM. Rhabdomyolysis and acute kidney injury. N Engl J Med. 2009;361:62-72. doi: 10.1056/NEJMra0801327. PubMed PMID: 19571284.
  9. Long B, Koyfman A, Gottlieb M. An evidence-based narrative review of the emergency department evaluation and management of rhabdomyolysis. Am J Emerg Med. 2019;37:518-23. doi: 10.1016/j.ajem.2018.12.061. PubMed PMID: 30630682.
  10. Mousavi SR, Vahabzadeh M, Mahdizadeh A, Vafaee M, Sadeghi M, Afshari R, et al. Rhabdomyolysis in 114 patients with acute poisonings. J Res Med Sci. 2015;20:239-43. PubMed PMID: 26109969; PubMed Central PMCID: PMCPMC4468227.
  11. Gupta A, Thorson P, Penmatsa KR, Gupta P. Rhabdomyolysis: Revisited. Ulster Med J. 2021;90:61-9. PubMed PMID: 34276082; PubMed Central PMCID: PMCPMC8278949.
  12. Talaie H, Pajouhmand A, Abdollahi M, Panahandeh R, Emami H, Hajinasrolah S, et al. Rhabdomyolysis among acute human poisoning cases. Hum Exp Toxicol. 2007;26:557-61. doi: 10.1177/0960327107078667. PubMed PMID: 17884958.
  13. Deighan CJ, Wong KM, McLaughlin KJ, Harden P. Rhabdomyolysis and acute renal failure resulting from alcohol and drug abuse. QJM. 2000;93:29-33. doi: 10.1093/qjmed/93.1.29. PubMed PMID: 10623779.
  14. Amanollahi A, Babeveynezhad T, Sedighi M, Shadnia S, Akbari S, Taheri M, et al. Incidence of rhabdomyolysis occurrence in psychoactive substances intoxication: a systematic review and meta-analysis. Sci Rep. 2023;13:17693. doi: 10.1038/s41598-023-45031-4. PubMed PMID: 37848606; PubMed Central PMCID: PMCPMC10582156.
  15. Faraji Dana H, Heidari Jafari E, Ghorbani M, Elsagh A. Study of Prevalence of Rhabdomyolysis Due to Poisoning and Its Relation with Clinical Findings of Patients Who Have Been Admitted in Rajaie Hospital Since 1397. Alborz University Medical Journal. 2021;10:249-54.
  16. Sharif MR, Nouri S. Clinical Signs and Symptoms and Laboratory Findings of Methadone Poisoning in Children. Iran J Pediatr. 2015;25:e176. doi: 10.5812/ijp.176. PubMed PMID: 26199683; PubMed Central PMCID: PMCPMC4505965.
  17. Torkashvand F, Sheikh Fathollahi M, Shamsi S, Kamali M, Rezaeian M. Evaluating the pattern of acute poisoning in cases referred to the Emergency Department of Ali-ebn Abi Taleb Hospital of Rafsanjan from October 2013 to September 2014. Journal of Rafsanjan University of Medical Sciences. 2015;14:311-24.
  18. Babak K, Mohammad A, Mazaher G, Samaneh A, Fatemeh T. Clinical and laboratory findings of rhabdomyolysis in opioid overdose patients in the intensive care unit of a poisoning center in 2014 in Iran. Epidemiol Health. 2017;39:e2017050. doi: 10.4178/epih.e2017050. PubMed PMID: 29121712; PubMed Central PMCID: PMCPMC5790980.
  19. Majidi M, Nekoueifard S. Seizure and Rhabdomyolysis: Serious Complications of Tramadol Overdose. Asia Pacific Journal of Medical Toxicology. 2014;3:90.
  20. Rodriguez E, Soler MJ, Rap O, Barrios C, Orfila MA, Pascual J. Risk factors for acute kidney injury in severe rhabdomyolysis. PLoS One. 2013;8:e82992. doi: 10.1371/journal.pone.0082992. PubMed PMID: 24367578; PubMed Central PMCID: PMCPMC3867454.
  21. Allameh Y, Akrami FS, Mohammadi G, Molavi N, Babakhanian M. Methadone poisoning in children: a systematic review and meta-analysis in Iran. Journal of Pediatrics Review. 2017;5:1-8. doi: 10.5812/jpr.10133.
  22. Wald R, Quinn RR, Luo J, Li P, Scales DC, Mamdani MM, et al. Chronic dialysis and death among survivors of acute kidney injury requiring dialysis. JAMA. 2009;302:1179-85. doi: 10.1001/jama.2009.1322. PubMed PMID: 19755696.
  23. Afzali S, TAHERI SK, SEIFRABIEI MA, Pourabdollah J. Acute poisoning in elderly; a five-year study (2008-2013) in Hamadan, Iran. Asia Pacific Journal of Medical Toxicology. 2015;4.
  24. Park JS, Seo MS, Gil HW, Yang JO, Lee EY, Hong SY. Incidence, etiology, and outcomes of rhabdomyolysis in a single tertiary referral center. J Korean Med Sci. 2013;28:1194-9. doi: 10.3346/jkms.2013.28.8.1194. PubMed PMID: 23960447; PubMed Central PMCID: PMCPMC3744708.
آمار
تعداد مشاهده مقاله: 101
تعداد دریافت فایل اصل مقاله: 89


سامانه مدیریت نشریات علمی. قدرت گرفته از سیناوب