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Xu, Shengnan, Ye, Chaoqiong, Wu, Zhihua, Wen, Chuying, Huang, Wenhui, Deng, Cong, Hua, Jiaye, Xie, Wei, Xiao, Min. (1404). Interleukin-14 prevents cytarabine or irradiation induced neutropenia via JAK/STAT3 signaling. سامانه مدیریت نشریات علمی, 22(2), 2-2. doi: 10.22034/iji.2025.105019.2925
Shengnan Xu; Chaoqiong Ye; Zhihua Wu; Chuying Wen; Wenhui Huang; Cong Deng; Jiaye Hua; Wei Xie; Min Xiao. "Interleukin-14 prevents cytarabine or irradiation induced neutropenia via JAK/STAT3 signaling". سامانه مدیریت نشریات علمی, 22, 2, 1404, 2-2. doi: 10.22034/iji.2025.105019.2925
Xu, Shengnan, Ye, Chaoqiong, Wu, Zhihua, Wen, Chuying, Huang, Wenhui, Deng, Cong, Hua, Jiaye, Xie, Wei, Xiao, Min. (1404). 'Interleukin-14 prevents cytarabine or irradiation induced neutropenia via JAK/STAT3 signaling', سامانه مدیریت نشریات علمی, 22(2), pp. 2-2. doi: 10.22034/iji.2025.105019.2925
Xu, Shengnan, Ye, Chaoqiong, Wu, Zhihua, Wen, Chuying, Huang, Wenhui, Deng, Cong, Hua, Jiaye, Xie, Wei, Xiao, Min. Interleukin-14 prevents cytarabine or irradiation induced neutropenia via JAK/STAT3 signaling. سامانه مدیریت نشریات علمی, 1404; 22(2): 2-2. doi: 10.22034/iji.2025.105019.2925

Interleukin-14 prevents cytarabine or irradiation induced neutropenia via JAK/STAT3 signaling

Iranian Journal of Immunology
دوره 22، شماره 2، شهریور 2025، صفحه 2-2
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22034/iji.2025.105019.2925
نویسندگان
Shengnan Xu؛ Chaoqiong Ye؛ Zhihua Wu؛ Chuying Wen؛ Wenhui Huang؛ Cong Deng؛ Jiaye Hua؛ Wei Xie؛ Min Xiao*
Department of Hematology, The Second Affiliated Hospital of Guangzhou Medical University, ‎ Guangzhou, 510260, China.
چکیده
Background: Severe neutropenia significantly increases the risk of bacterial infections. Recent studies have shown that the cytokine interleukin 14 (IL-14) plays an important role in immune cells, but its potential role in neutropenia induced by cytarabine (ara-c) or irradiation is unclear.
Objective: To investigate the role of IL-14 in ara-c or irradiation-induced neutropenia.
Methods: Two neutropenia models were induced by ara-c or irradiation. Neutrophil count was confirmed through flow cytometry and routine blood tests. IL-14 was used to assess the impact on neutropenia. IL-14 expression was analyzed using qPCR, Western blotting and ELISA. A IL-14 receptor (IL-14R) knockout mice model was utilized to confirm the role of IL-14R/STAT3 signaling in vivo.
Results: The results indicated that IL-14 treatment promoted proliferation and increased neutrophil counts in both bone marrow and peripheral blood, while IL-14R knockout suppressed this process. Furthermore, the downstream molecule of IL-14R, STAT3, showed enhanced phosphorylation levels in the presence of IL-14. Finally, we explored the source of IL-14 in the bone marrow, and found that lymphocytes secreted the highest levels of IL-14. Serum levels of IL-14 were significantly reduced in patients after chemotherapy.
Conclusions: These results indicate that IL-14 prevents ara-c or irradiation-induced neutropenia by regulating lymphocytes and activating the IL-14R/STAT3 pathway in neutrophils. This evidence suggests that IL-14 is a potent cytokine for treating ara-c or irradiation-induced neutropenia.
کلیدواژه‌ها
Cytarabine؛ Interleukin 14؛ Irradiation؛ Neutropenia؛ STAT3‎
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