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Investigating the Relationship of Human Parvovirus Type B19 Infection in Benign and Malignant Salivary Gland Tumors | ||
| Journal of Dentistry | ||
| مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 21 خرداد 1404 اصل مقاله (345.52 K) | ||
| نوع مقاله: Original Article | ||
| شناسه دیجیتال (DOI): 10.30476/dentjods.2025.102008.2330 | ||
| نویسندگان | ||
| Ali Farhadi1؛ Ali Dehghani Nazhvani* 2؛ Fateneh Faghihi2؛ Mohammad Hadi Khademi3؛ Hasan Rezazadeh3 | ||
| 1Dept. of Virology, Dept. of Laboratory Sciences, Faculty of Paramedicine, Shiraz University of Medical Sciences, Shiraz, Iran. | ||
| 2Dept. of Oral and Maxillofacial Pathology, Biomaterials Research Center, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran. | ||
| 3Student Research Committee, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran. | ||
| چکیده | ||
| Background: Parvovirus B19 is a common virus that can affect everyone, especially immunocompromised patients. The virus is present in various leukemias and solid tumors, and several B19-related diseases including autoimmune disorders, hepatitis, vasculitis, acute and chronic inflammatory diseases, and some thyroid cancers have been described. Purpose: This investigation aimed to quantify the frequency of human Parvovirus-B19 infection in salivary gland tumors, both benign and malignant. Materials and Method: In this cross-sectional study, 71 formalin-fixed, paraffin-embedded tissue specimens associated with benign and malignant salivary gland tumors, along with tissues from 31 normal salivary glands from the maxillofacial pathology laboratory of Shiraz Dental School, Chamran, and Rajai teaching hospitals (the main two major referral centers), were examined using nested-PCR to determine if B19 DNA was present. All data, including age, sex, location, and the presence of the virus, were considered, presented in tables, and statistically analyzed. The prevalence of B19 was compared to the normal salivary gland group. Results: B19 DNA was identified in 11 specimens (15.5%) out of the 71 available specimens from the patient group. None of the specimens from the normal salivary gland group tested positive for B19 DNA. Consequently, the prevalence of B19 in the patient group was significantly higher than that in the normal salivary gland group (P value = 0.031). There was no significant relationship between age, sex, location, type of tumor, and the presence of B19 infection. Conclusion: Our results indicated a relationship between presence of B19 parvovirus in the patient group compared to that in the control groups. Based on our study's findings, it can be said that B19 virus is likely to be presenting in both benign and malignant salivary gland tumors. | ||
| کلیدواژه‌ها | ||
| Salivary gland tumor؛ Parvovirus B19؛ Pleomorphic adenoma؛ Mucoepidermoid carcinoma؛ Adenoid cystic carcinoma | ||
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آمار تعداد مشاهده مقاله: 13 تعداد دریافت فایل اصل مقاله: 7 |
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