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Akbari, Fatemeh, Hosseinimehr, Seyed Jalal, Noruz, Marzieh, Ebrahimi, Fatemeh, Bagheri, Ali, Vahedi, Lale, Azadbakht, Mohammad. (1404). Assessment of the Impact of Astragalus floccosus Boiss. Extract on Wound Based on Phytoestrogenic Properties: An In vitro and In vivo Study. سامانه مدیریت نشریات علمی, 50(6), 404-415. doi: 10.30476/ijms.2024.103120.3634
Fatemeh Akbari; Seyed Jalal Hosseinimehr; Marzieh Noruz; Fatemeh Ebrahimi; Ali Bagheri; Lale Vahedi; Mohammad Azadbakht. "Assessment of the Impact of Astragalus floccosus Boiss. Extract on Wound Based on Phytoestrogenic Properties: An In vitro and In vivo Study". سامانه مدیریت نشریات علمی, 50, 6, 1404, 404-415. doi: 10.30476/ijms.2024.103120.3634
Akbari, Fatemeh, Hosseinimehr, Seyed Jalal, Noruz, Marzieh, Ebrahimi, Fatemeh, Bagheri, Ali, Vahedi, Lale, Azadbakht, Mohammad. (1404). 'Assessment of the Impact of Astragalus floccosus Boiss. Extract on Wound Based on Phytoestrogenic Properties: An In vitro and In vivo Study', سامانه مدیریت نشریات علمی, 50(6), pp. 404-415. doi: 10.30476/ijms.2024.103120.3634
Akbari, Fatemeh, Hosseinimehr, Seyed Jalal, Noruz, Marzieh, Ebrahimi, Fatemeh, Bagheri, Ali, Vahedi, Lale, Azadbakht, Mohammad. Assessment of the Impact of Astragalus floccosus Boiss. Extract on Wound Based on Phytoestrogenic Properties: An In vitro and In vivo Study. سامانه مدیریت نشریات علمی, 1404; 50(6): 404-415. doi: 10.30476/ijms.2024.103120.3634

Assessment of the Impact of Astragalus floccosus Boiss. Extract on Wound Based on Phytoestrogenic Properties: An In vitro and In vivo Study

Iranian Journal of Medical Sciences
مقاله 5، دوره 50، شماره 6، شهریور 2025، صفحه 404-415    اصل مقاله (2.6 M)
نوع مقاله: Original Article(s)
شناسه دیجیتال (DOI): 10.30476/ijms.2024.103120.3634
نویسندگان
Fatemeh Akbari1؛ Seyed Jalal Hosseinimehr2؛ Marzieh Noruz1؛ Fatemeh Ebrahimi2؛ Ali Bagheri3؛ Lale Vahedi4؛ Mohammad Azadbakht* 5
1Department of Pharmacognosy, School of Pharmacy, Semnan University of Medical Sciences, Semnan, Iran
2Department of Radiopharmacy, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran
3Department of Plant and Animal Biology, Faculty of Biological Science and Technology, University of Isfahan, Isfahan, Iran
4Department of Pathology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
5Department of Pharmacognosy, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran
چکیده
Background: Investigations have shown that estrogen affects wound healing through skin receptors. Astragalus floccosus Boiss. contains estrogen-like isoflavonoids. This study examined the effects of A. floccosus Boiss (A. floccosus) extract on wound healing in vitro and in vivo.
Methods: For the in vitro test, Human Fetal Foreskin Fibroblast 2 (HFFF2) cells treated with the root extract of A. floccosus were followed over a 48-hour period. For the in vivo test, rats were categorized into five groups and received daily applications of a cream containing different concentrations of the extract: 5%, 10%, silver sulfadiazine, the ointment base, and no treatment for a duration of 21 days. The wound size and full-thickness wound healing were measured throughout the inspection, and a histological study was conducted as well. The two-way repeated measures ANOVA test was employed, with a significance level of 0.05 (P≤0.05) being used in all cases.
Results: A. floccosus at 125 ppm significantly improved the closer region and wound healing in HFFF2 cells over all periods of time and showed a significant healing effect during 8-12 h (P=0.0234). Moreover, an increase in fibrosis (compared to the base (P=0.0005), the 10% extract (P<0.0001), silver (P=0.0005), and free (P<0.0001) groups), epithelization (compared to base (P=0.0006), the 10% extract (P=0.0008), silver (P=0.0007), and free (P=0.0006) groups), and proliferation of fibroblasts (compared to the 10% extract and free groups (P=0.0020 and P=0.0024, respectively) were seen in the 5% extract sample on day 10. 
Conclusion: Wound healing processes were observed in rats treated with a 5% A. floccosus extract cream. This finding highlights the potential for future studies on wound healing processes using this extract.

تازه های تحقیق

Fatemeh Akbari (Google Scholar)

Mohammad Azadbakht (Google Scholar)

کلیدواژه‌ها
Astragalus plant؛ Wound healing؛ Flavonoids؛ Chromatography؛ Cell line
مراجع
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