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Commentary on Boswellia and Ginger for Memory Dysfunction in Mild TBI | ||
Bulletin of Emergency And Trauma | ||
مقاله 8، دوره 13، شماره 2، تیر 2025، صفحه 123-125 اصل مقاله (481.24 K) | ||
نوع مقاله: Letter to the Editor | ||
شناسه دیجیتال (DOI): 10.30476/beat.2025.106323.1590 | ||
نویسنده | ||
mohammad farhadi* | ||
medical student, Clinical research development center, Amir oncology hospital, Shiraz University of Medical Sciences, Shiraz, Iran | ||
چکیده | ||
I commend the authors for their insightful manuscript "Effect of a Boswellia and Ginger Mixture on the Memory Dysfunction of the Mild Traumatic Brain Injury Patients: A Randomized, Double-Blind Controlled Trial(1)This study examines whether a combination of Boswellia (360 mg) and ginger (36 mg) taken three times per day (marketed as “Memoral”) can improve memory deficits in patients who have sustained a mild traumatic brain injury (mTBI). One hundred patients were randomized (1:1) into either the intervention or placebo groups. All participants had subjective complaints of memory dysfunction post-injury. Memory performance was assessed at baseline (about one-week post-discharge), after one month (when the intervention was complete), and after three months, using the Persian version of the Rey Auditory-Verbal Learning Test (AVLT). Overall, this trial contributes valuable preliminary evidence that combining Boswellia and ginger may help hasten or strengthen recovery from memory dysfunction after mild TBI, at least over three months. The authors implemented a robust RCT methodology and demonstrated statistically significant improvements in several memory metrics (Total Learning, Retroactive Interference, Forgetting Rate, Net Positive Score) with no notable adverse effects. However, replication in larger, multi-center cohorts (emphasizing longer follow-up, formal adherence checks, and additional potential confounders) is needed as with many single-center trials. Future investigations measuring inflammatory and oxidative markers would also help clarify the mechanism of action. Despite these limitations, the study’s design and results suggest that the Boswellia–ginger mixture holds promise as an adjunct therapy for post-mTBI memory dysfunction. | ||
کلیدواژهها | ||
Trauma؛ memory؛ clinical trial | ||
اصل مقاله | ||
Dear Editor
I commend the authors for their insightful manuscript “Effect of a Boswellia and Ginger Mixture on the Memory Dysfunction in Mild Traumatic Brain Injury Patients: A Randomized, Double-Blind Controlled Trial”[1]. This study investigated whether a combination of Boswellia (360 mg) and ginger (36 mg), administered three times daily (marketed as “Memoral”), could improve memory deficits in patients with mild traumatic brain injury (mTBI). One hundred patients were randomized (1:1) into either the intervention or placebo groups. All participants reported subjective memory dysfunction post-injury. Memory performance was assessed at three-time points: baseline (approximately one-week post-discharge), after one month (completion of the intervention), and after three months, using the Persian version of the Rey Auditory-Verbal Learning Test (AVLT).
Strengths of the Study
Areas for Further Consideration
Overall, this trial provided valuable preliminary evidence that a Boswellia-ginger combination might accelerate or enhance recovery from memory dysfunction after mTBI, with benefits sustained over three months. The authors implemented a robust RCT design and reported statistically significant improvements across several memory metrics (Total Learning, Retroactive Interference, Forgetting Rate, Net Positive Score), with no notable adverse effects. However, as with many single-center trials, replication in larger, multi-center cohorts, with longer follow-up, formal adherence monitoring, and control for additional confounders, is warranted. Future studies incorporating inflammatory and oxidative biomarker analyses could further elucidate the mechanism of action. Despite these limitations, the study’s methodology and positive outcomes suggested that the Boswellia–ginger mixture holds promise as an adjunct therapy for post-mTBI memory dysfunction.
Declaration
Ethical approval and consent to participate: Not applicable.
Consent for Publication: All authors provide consent for the publication of this manuscript.
Conflict of Interest: The authors declared that they had no competing interests to declare.
Funding: This piece received no specific grant from funding agencies in the public, commercial, or not-for-profit sectors.
Authors’ Contribution: All authors contributed equally to all study aspects, including conceptualization, methodology, data collection, analysis, manuscript writing, and revision.
Acknowledgments: We sincerely thank the Clinical Research Development Center, Amir Oncology Teaching Hospital, and Shiraz University of Medical Sciences for their valuable mentorship and scientific support in the development of this article.
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