| Oncocytomas are benign tumors of salivary glands, characterized histopathologically by large epithelial cells with bright and eosinophilic cytoplasm. They occur mostly in parotid glands, with only a small percentage of these tumors occurring in minor salivary glands of buccal, mucosa, palate, maxillary sinus, and tonsillar fossa. They occur primarily in people older than 50 years and generally have a female predilection. Few authors have suggested that oncocytomas of minor salivary glands are more aggressive in nature in comparison to their major salivary gland counterparts. An exhaustive literature review of English language literature revealed 20 cases of minor salivary glands; hence, the present case is 21st case of minor salivary gland oncocytoma. We report a case of palatal oncocytoma in a 31-year-old male which was provisionally diagnosed as pleomorphic adenoma and also describe the immunohistochemical characteristics of this rare tumor of minor salivary glands. |
- Hamperl H. Beiträge zur normalen und pathologischen Histologie menschlichen Speicheldrüsen. Z Mikrosk Anat Forsch. 1931; 27: 1.
- Jaffe RH. Adenolymphoma (onkocytoma) of the parotid gland. American J Cancer. 1932; 16: 1414–1423.
- Meza-Chavez L. Oxyphilic granular cell adenoma of the parotid gland (oncocytoma) report of five cases and study of oxyphilic granular cells (oncocytes) in normal parotid glands. Am J Pathol. 1949; 25: 523-547.
- Ahlbom HE. Mucous and salivary gland tumours: A clinical study with special reference to radiotherapy, based on 254 cases treated at Radiumhemmet. Stockholm Acta Radiol.1935; 23:257.
- Miyoshi Y, Ohyama M, Takahashi S. A case of oxyphilicacinic cell adenoma of the soft palate. J Otolaryngol Jpn.1963; 66: 1258.
- Sato S, Watanabe T. Case of oncocytoma of the hard palate; a statistical survey on the cases of palatal neoplasms in japan. Jibiinkoka. 1964; 36: 855-860.
- Majumdar AB, Paul SS, Sarker G, Ray S. Oncocytoma of oral cavity mimicking as jaw tumor. Case Rep Otolaryngol. 2014; 2014: 315058.
- Kanazawa H, Furuya T, Murano A, Yamaki M. Oncocytoma of an intraoral minor salivary gland: report of a case and review of literature. J Oral Maxillofac Surg. 2000; 58: 894-897.
- Chau MN, Radden BG. Intra-oral benign solid oncocytoma. Int J Oral Maxillofac Surg. 1986; 15: 503-506.
- Crocker DJ, Cavalaris CJ, Finch R. Intraoral minor salivary gland tumors. Report of thirty-eight cases. Oral Surg Oral Med Oral Pathol. 1970; 29: 60-68.
- Jalisi M. Oncocytoma of the accessory salivary glands. J Laryngol Otol. 1968; 82: 257-259.
- Sato S, Watanabe T. Case of oncocytoma of the hard palate; a statistical survey on the cases of palatal neoplasms in japan. Jibiinkoka. 1964; 36: 855-860.
- Matsuda N, Kato J, Imano K, Imai S, Nonaka T. A case of oncocytoma of the right cheek (author's transl). Nihon Koku Geka Gakkai Zasshi. 1974; 20: 278-280.
- Shahi S, Bhandari TR, Thapa PB, Shrestha D. Buccal oncocytoma: Report of a case and literature review. Ann Med Surg (Lond). 2019; 43: 82-84.
- Regezi JA, Lloyd RV, Zarbo RJ, McClatchey KD. Minor salivary gland tumors: a histologic and immunohistochemical study. Cancer. 1985; 55: 108–115.
- Camara AC, Kelner N, Kauffman CMF, Lima KP, Henriques ACG, de Castro JFL. Oncocytoma of an intraoral minor salivary gland: case report and review of literature. Applied Cancer Research. 2005; 25: 90-92.
- Hung T. Electron microscopic observations on oncocytoma removed from the hard palate. Jibiinkoka. 1969; 41: 867-876.
- Palakshappa SG, Bansal V, Reddy V, Kamarthi N. Oncocytoma of minor salivary gland involving the retromolar region: A rare entity. J Oral Maxillofac Pathol. 2014; 18: 127-130.
- Kochhar L, Kumar S, Deka RC, Bose S. Oncocytoma of the minor salivary glands of hard palate. Indian J Otolaryngol. 1990; 42: 132–133.
- Hayashi S, Kawabe R, Umino T. Two cases of oxyphilic adenoma of the palate. Journal Japan Stomatological Society. 1985; 34: 344.
- Yilmaz N, Gonulol E, Bereket CM, Karaka C, Temiz P. An uncommon benign tumor of oral minor salivary glands: a case of oncocytoma. J Dent Fac Ataturk Univ. 2011; 4: 77–79.
- Alberto PL, Ashim S, Megan K, Wei Z, Nestor G, Matthew Z, et al. Salivary Gland Oncocytomas. A Systematic Review. Head Neck Pathol. 2024; 18: 126.
- Shinmura K, Kato H, Kawanishi Y, Kamo T, Inoue Y, Yoshimura K, et al. BSND is a Novel Immunohistochemical Marker for Oncocytic Salivary Gland Tumors. Pathol Oncol Res. 2018; 24: 439-444.
- Katabi N. Oncocytoid Salivary Tumors: Differential Diagnosis and Utility of Newly Described Immunohistochemistry. Head Neck Pathol. 2024; 18: 20.
|