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Mortazavi, Farid, Tamaddon, Paria, Ketabi, Ali, Haghighi, Hanieh, Khajeheian, Kiana, Haghani, Masoud, Mahmoudi, Tahereh, Masjoodi, Sadegh, Negahdary, Masoud, Sattarahmady, Naghmeh. (1404). Selenium-Curcumin-PEG Nanoparticles Radiosensitization for Intensity-Modulated Radiation Therapy of Lung Tumor Cells: In Vitro Synergistic Combination Therapy. سامانه مدیریت نشریات علمی, (), -. doi: 10.31661/jbpe.v0i0.2502-1887
Farid Mortazavi; Paria Tamaddon; Ali Ketabi; Hanieh Haghighi; Kiana Khajeheian; Masoud Haghani; Tahereh Mahmoudi; Sadegh Masjoodi; Masoud Negahdary; Naghmeh Sattarahmady. "Selenium-Curcumin-PEG Nanoparticles Radiosensitization for Intensity-Modulated Radiation Therapy of Lung Tumor Cells: In Vitro Synergistic Combination Therapy". سامانه مدیریت نشریات علمی, , , 1404, -. doi: 10.31661/jbpe.v0i0.2502-1887
Mortazavi, Farid, Tamaddon, Paria, Ketabi, Ali, Haghighi, Hanieh, Khajeheian, Kiana, Haghani, Masoud, Mahmoudi, Tahereh, Masjoodi, Sadegh, Negahdary, Masoud, Sattarahmady, Naghmeh. (1404). 'Selenium-Curcumin-PEG Nanoparticles Radiosensitization for Intensity-Modulated Radiation Therapy of Lung Tumor Cells: In Vitro Synergistic Combination Therapy', سامانه مدیریت نشریات علمی, (), pp. -. doi: 10.31661/jbpe.v0i0.2502-1887
Mortazavi, Farid, Tamaddon, Paria, Ketabi, Ali, Haghighi, Hanieh, Khajeheian, Kiana, Haghani, Masoud, Mahmoudi, Tahereh, Masjoodi, Sadegh, Negahdary, Masoud, Sattarahmady, Naghmeh. Selenium-Curcumin-PEG Nanoparticles Radiosensitization for Intensity-Modulated Radiation Therapy of Lung Tumor Cells: In Vitro Synergistic Combination Therapy. سامانه مدیریت نشریات علمی, 1404; (): -. doi: 10.31661/jbpe.v0i0.2502-1887

Selenium-Curcumin-PEG Nanoparticles Radiosensitization for Intensity-Modulated Radiation Therapy of Lung Tumor Cells: In Vitro Synergistic Combination Therapy

Journal of Biomedical Physics and Engineering
مقالات آماده انتشار، اصلاح شده برای چاپ، انتشار آنلاین از تاریخ 15 اردیبهشت 1404    اصل مقاله (1.53 M)
نوع مقاله: Original Research
شناسه دیجیتال (DOI): 10.31661/jbpe.v0i0.2502-1887
نویسندگان
Farid Mortazavi1، 2؛ Paria Tamaddon2؛ Ali Ketabi1، 3؛ Hanieh Haghighi4؛ Kiana Khajeheian2؛ Masoud Haghani4، 5؛ Tahereh Mahmoudi4، 2؛ Sadegh Masjoodi6؛ Masoud Negahdary7، 8؛ Naghmeh Sattarahmady* 4، 2
1Nanomedicine and Nanobiology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
2Department of Medical Physics and Engineering, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
3Physics Unit, Department of Radio-oncology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
4Nanomedicine and Nanobiology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
5Department of Radiology, School of Paramedical Science, Shiraz University of Medical Sciences, Shiraz, Iran
6Neuroscience Research Centre, Shiraz University of Medical Sciences, Shiraz, Iran
7Department of Biomedical Engineering, Texas A&M University, 600 Discovery Drive, College Station, TX, 77840-3006, USA
8Center for Remote Health Technologies & Systems, Texas A&M Engineering Experiment Station, 600 Discovery Drive, College Station, TX, 77840-3006, USA
چکیده
Background: Lung cancer is a leading cause of cancer-related mortality worldwide, underscoring the need for the development of more effective treatment strategies. Radiotherapy (RT), particularly intensity-modulated radiation therapy (IMRT), has enhanced tumor targeting while minimizing damage to healthy tissues. Nevertheless, radioresistance and challenges posed by the tumor microenvironment limit its efficacy.
Objective: Selenium-curcumin-polyethylene glycol 600 nanoparticles (Se-Cur-PEG NPs) analyzed as radiosensitizers in IMRT for lung cancer treatment.
Material and Methods: In this experimental study, Se-Cur-PEG NPs were synthesized and characterized for their potential as radiosensitizers.
Results: The in vitro toxicity of Se-Cur-PEG NPs against A549 lung cancer cells was evaluated using MTT assays, demonstrating a dose-dependent reduction in cell viability. The combination of Se-Cur-PEG NPs (50 µg mL-1) with IMRT (4 Gy) resulted in a significant enhancement in cell death compared to either treatment alone, indicating a strong synergistic effect (CI=1.21) and a notable sensitizer enhancement ratio (SER=2.5). Intracellular ROS generation analysis confirmed that Se-Cur-PEG NPs amplified IMRT-induced oxidative stress, contributing to increased cancer cell toxicity. 
Conclusion: These findings suggest that Se-Cur-PEG NPs hold promise as effective radiosensitizers, potentially improving lung cancer RT outcomes.
کلیدواژه‌ها
Intensity-Modulated؛ Lung Neoplasms؛ Selenium nanoparticles؛ Oxidative Stress؛ Radiation-Sensitizing Agents
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