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The Effect of Vitamin K Supplementation on Glycemic Indices in Adults: A Systematic Review and Meta- Analysis of Clinical Trials | ||
| International Journal of Nutrition Sciences | ||
| مقاله 1، دوره 10، شماره 2، شهریور 2025، صفحه 186-198 اصل مقاله (1.42 M) | ||
| نوع مقاله: Review Article | ||
| شناسه دیجیتال (DOI): 10.30476/ijns.2025.103594.1336 | ||
| نویسندگان | ||
| Saba Khatapoush1؛ Mohsen Mohit1؛ Fatemeh Mansouri Shirazi1؛ Mahsa Moazen2؛ Armin Ebrahimzadeh1؛ Najmeh Hejazi* 2 | ||
| 1Student Research Committee, Department of Clinical Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran | ||
| 2Department of Clinical Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran | ||
| چکیده | ||
| Background: Vitamin K supplementation was shown to be effective on glucose hemostasis and insulin sensitivity in some previous studies, but the results are controversial. The purpose of this meta-analysis was to investigate the effect of vitamin K supplementation on glycemic indices including fasting blood sugar (FBS), hemoglobin A1c (HbA1c), fasting insulin (FI), homeostatic model assessment for insulin resistance (HOMA-IR), quantitative insulin-sensitivity check index (QUICKI) and homeostasis model assessment of β-cell function (HOMA-β). Methods: The systematic search of literatures was performed on electronic databases of PubMed, Scopus, and Web of Science databases up to December, 2024. The weighted mean difference (WMD) and 95% confidence intervals (95% CI) were calculated to evaluate the pooled effect size using the random-effect model. The heterogeneity was evaluated using I-square (I2) statistics. Subgroup analysis was done to evaluate the potential sources of heterogeneity. Results: Among all of the eligible studies, six randomized clinical trials (RCTs) were included in this meta-analysis. The results showed a significant effect of vitamin K supplementation on some glycemic indices including FI (WMD: -1.87; 95% CI: -2.64, -1.09), HbA1c (WMD: -0.89; 95% CI: -1.40, -0.38) and HOMA-IR (WMD: -0.35; 95% CI: -0.39, -0.31). Also, the effect of vitamin K supplementation on other glycemic indices including FBS (WMD: -4.74; 95% CI: -10.56, 1.09), HOMA-β (WMD: -0.36; 95% CI: -1.44, 0.73) were not a significant effect. Conclusion: The findings of this study indicated that vitamin K supplementation can positively affect FI, HbA1c, and HOMA-IR levels. | ||
تازه های تحقیق | ||
Najmeh Hejazi (Google Scholar) | ||
| کلیدواژه‌ها | ||
| Vitamin K؛ Glycemic indices؛ Fasting blood sugar؛ Insulin؛ Adult | ||
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آمار تعداد مشاهده مقاله: 101 تعداد دریافت فایل اصل مقاله: 134 |
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