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Vatankhah, Pooya, Khosravi, Mohammad Bagher, Eghbal, Mohammad Hossein, Asmarian, Naeimehossadat, Sahmeddini, Mohammad Ali, Khalili, Fatemeh, Ghazanfar Tehran, Samaneh, Nikoupour, Hamed, Shamsaeefar, Alireza, Kazemi, Kourosh, Sohrabi Nazari, Sahar, Nikeghbalian, Saman, Malekhosseini, Seyed Ali. (1404). Characteristics and Outcome of Partial Liver Transplant among Pediatrics in a Referral Transplant Center in Iran from 2010 to 2020. سامانه مدیریت نشریات علمی, (), -. doi: 10.30476/ijms.2024.102949.3608
Pooya Vatankhah; Mohammad Bagher Khosravi; Mohammad Hossein Eghbal; Naeimehossadat Asmarian; Mohammad Ali Sahmeddini; Fatemeh Khalili; Samaneh Ghazanfar Tehran; Hamed Nikoupour; Alireza Shamsaeefar; Kourosh Kazemi; Sahar Sohrabi Nazari; Saman Nikeghbalian; Seyed Ali Malekhosseini. "Characteristics and Outcome of Partial Liver Transplant among Pediatrics in a Referral Transplant Center in Iran from 2010 to 2020". سامانه مدیریت نشریات علمی, , , 1404, -. doi: 10.30476/ijms.2024.102949.3608
Vatankhah, Pooya, Khosravi, Mohammad Bagher, Eghbal, Mohammad Hossein, Asmarian, Naeimehossadat, Sahmeddini, Mohammad Ali, Khalili, Fatemeh, Ghazanfar Tehran, Samaneh, Nikoupour, Hamed, Shamsaeefar, Alireza, Kazemi, Kourosh, Sohrabi Nazari, Sahar, Nikeghbalian, Saman, Malekhosseini, Seyed Ali. (1404). 'Characteristics and Outcome of Partial Liver Transplant among Pediatrics in a Referral Transplant Center in Iran from 2010 to 2020', سامانه مدیریت نشریات علمی, (), pp. -. doi: 10.30476/ijms.2024.102949.3608
Vatankhah, Pooya, Khosravi, Mohammad Bagher, Eghbal, Mohammad Hossein, Asmarian, Naeimehossadat, Sahmeddini, Mohammad Ali, Khalili, Fatemeh, Ghazanfar Tehran, Samaneh, Nikoupour, Hamed, Shamsaeefar, Alireza, Kazemi, Kourosh, Sohrabi Nazari, Sahar, Nikeghbalian, Saman, Malekhosseini, Seyed Ali. Characteristics and Outcome of Partial Liver Transplant among Pediatrics in a Referral Transplant Center in Iran from 2010 to 2020. سامانه مدیریت نشریات علمی, 1404; (): -. doi: 10.30476/ijms.2024.102949.3608

Characteristics and Outcome of Partial Liver Transplant among Pediatrics in a Referral Transplant Center in Iran from 2010 to 2020

Iranian Journal of Medical Sciences
مقالات آماده انتشار، اصلاح شده برای چاپ، انتشار آنلاین از تاریخ 27 فروردین 1404    اصل مقاله (376.17 K)
نوع مقاله: Original Article(s)
شناسه دیجیتال (DOI): 10.30476/ijms.2024.102949.3608
نویسندگان
Pooya Vatankhah1، 2؛ Mohammad Bagher Khosravi* 1؛ Mohammad Hossein Eghbal1؛ Naeimehossadat Asmarian1؛ Mohammad Ali Sahmeddini1؛ Fatemeh Khalili1؛ Samaneh Ghazanfar Tehran2، 3؛ Hamed Nikoupour2؛ Alireza Shamsaeefar4؛ Kourosh Kazemi2؛ Sahar Sohrabi Nazari2؛ Saman Nikeghbalian2؛ Seyed Ali Malekhosseini2
1Anesthesiology and Critical Care Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
2Shiraz Transplant Center, Abu-Alisina Hospital, Shiraz University of Medical Sciences, Shiraz, Iran
3Anesthesiology Research Center, Department of Anesthesiology, Alzahra Hospital, Guilan University of Medical Sciences, Rasht, Iran
4Department of Surgery, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
چکیده
Background: Liver transplantation (LT) is a critical intervention for pediatric patients with advanced liver failure. This study aimed to assess the impact of perioperative factors on LT outcomes in pediatric patients.
Methods: This retrospective cohort study, conducted from 2010-2020, included 563 pediatric patients who underwent LT in Shiraz, Iran. Most patients received liver grafts from living donors due to cholestatic and metabolic diseases, and all had complete medical and laboratory records. Data were analyzed using various regression models (Cox, linear, and logistic) in SPSS software (version 22).
Results: Of the 563 patients who underwent LT, 436 received livers from living donors and 127 from deceased donors. The primary diagnoses included cholestatic diseases (44.4%) and metabolic diseases (34.1%). Post-transplant rejection and mortality rates were 21.1% (119 patients) and 36.1% (203 patients), respectively. Preoperative factors associated with rejection included weight (HR=1.01, P=0.01) and albumin (HR=0.69, P=0.03). Postoperative factors influencing rejection included platelet transfusion (HR=2.12, P=0.03), primary non-function (PNF) (HR=4.6, P=0.01), cytomegalovirus (CMV)(HR=1.78, P=0.005), and convulsion (HR=1.93, P=0.007). Preoperative factors that affect mortality were age (HR=0.89, P<0.001), alanine aminotransferase (ALT) (HR=1, P=0.047), and hemoglobin levels (HR=0.91, P=0.03). Intraoperative factors influencing mortality included cold ischemia duration (HR=0.98, P=0.048) and anhepatic blood loss (HR=1.02, P<0.001). Postoperative factors associated with mortality included fresh frozen plasma (FFP) transfusion (HR=1.7, P=0.004), bleeding (HR=2.17, P=0.009), bowel perforation (HR=2.55, P=0.01), and PNF (HR=11.24, P<0.001). 
Conclusion: Optimizing perioperative care practices could significantly improve LT outcomes in pediatric patients.
کلیدواژه‌ها
Pediatrics؛ Liver transplantation؛ Mortality؛ Graft rejection؛ Reperfusion
مراجع
 

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