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KHALID, MOHAMMED, Kumar BS, Ashok, NS, Disha, A, Chaithanya. (1403). Mechanism of Interaction between Nanoparticles and the Body: Molecular, Cellular, and Tissular Levels – a review. سامانه مدیریت نشریات علمی, 11(1), 73-86. doi: 10.30476/tips.2024.103004.1245
MOHAMMED KHALID; Ashok Kumar BS; Disha NS; Chaithanya A. "Mechanism of Interaction between Nanoparticles and the Body: Molecular, Cellular, and Tissular Levels – a review". سامانه مدیریت نشریات علمی, 11, 1, 1403, 73-86. doi: 10.30476/tips.2024.103004.1245
KHALID, MOHAMMED, Kumar BS, Ashok, NS, Disha, A, Chaithanya. (1403). 'Mechanism of Interaction between Nanoparticles and the Body: Molecular, Cellular, and Tissular Levels – a review', سامانه مدیریت نشریات علمی, 11(1), pp. 73-86. doi: 10.30476/tips.2024.103004.1245
KHALID, MOHAMMED, Kumar BS, Ashok, NS, Disha, A, Chaithanya. Mechanism of Interaction between Nanoparticles and the Body: Molecular, Cellular, and Tissular Levels – a review. سامانه مدیریت نشریات علمی, 1403; 11(1): 73-86. doi: 10.30476/tips.2024.103004.1245

Mechanism of Interaction between Nanoparticles and the Body: Molecular, Cellular, and Tissular Levels – a review

Trends in Pharmaceutical Sciences and Technologies
مقاله 7، دوره 11، شماره 1، خرداد 2025، صفحه 73-86    اصل مقاله (418.08 K)
نوع مقاله: Review Article
شناسه دیجیتال (DOI): 10.30476/tips.2024.103004.1245
نویسندگان
MOHAMMED KHALID* 1؛ Ashok Kumar BS2؛ Disha NS3؛ Chaithanya A3
1Department of Pharmaceutics, R.L Jalappa College of Pharmacy, Sri Devaraj Urs Academy Higher Education and Research (a Deemed to be University), Tamaka, Kolar, India.
2Department of Pharmacognosy, R.L Jalappa College of Pharmacy, Sri Devaraj Urs Academy Higher Education and Research (a Deemed to be University), Tamaka, Kolar, India.
3Department of Pharmaceutical Chemistry, R.L Jalappa College of Pharmacy, Sri Devaraj Urs Academy Higher Education and Research (a Deemed to be University), Tamaka, Kolar, India.
چکیده
Nanoparticles (NPs), ranging from 1 to 100 nanometers, exhibit unique properties that enable their use in medical applications such as drug delivery, diagnostics, and therapies. Their interactions with biological systems occur at molecular, cellular, and tissue levels, significantly influencing their behavior and efficacy. At the molecular level, NPs form a dynamic protein corona in biological fluids, affecting cellular uptake and biodistribution. NPs also interact with lipids and nucleic acids, impacting membrane integrity and gene delivery. Cellular uptake of NPs involves various endocytic pathways, influencing intracellular trafficking and potential cytotoxicity. Tissue-level interactions determine NP biodistribution, with accumulation in organs like the liver, spleen, and brain posing both therapeutic opportunities and safety concerns. Comprehensive studies on NP safety, biocompatibility, and regulatory guidelines are essential for advancing nanomedicine. This review delves into the mechanisms of these interactions, referencing key studies and highlighting their implications for the development of nanomedicine.

تازه های تحقیق

Mohammed Khalid (Google Scholar)

Ashok Kumar BS (Google Scholar)

کلیدواژه‌ها
Nanoparticles؛ Molecular؛ Cellular؛ Tissue؛ Efficacy
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