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The Effect of Banana (Musa nana Lour.) Peel Extract and Omega-3 on Biochemical and Histopathological Characteritics in Rat Model of Polycystic Ovary Syndrome | ||
| International Journal of Nutrition Sciences | ||
| مقاله 10، دوره 10، شماره 1، خرداد 2025، صفحه 93-103 اصل مقاله (1.76 M) | ||
| نوع مقاله: Original Article | ||
| شناسه دیجیتال (DOI): 10.30476/ijns.2025.101331.1297 | ||
| نویسندگان | ||
| Jamal Yazdani1؛ Mohammad-Jafar Dehzad1؛ Mohammad Mehdi Ommati2، 3؛ Reza Heidari3؛ Mohammad Reza Arabnezhad4؛ Najmeh Hejazi* 5؛ Afsaneh Ahmadi5 | ||
| 1Department of Clinical Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran | ||
| 2Henan Key Laboratory of Environmental and Animal Product Safety, College of Animal Science and Technology, Henan University of Science and Technology, Luoyang 471000, Henan, China | ||
| 3Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran | ||
| 4Department of Toxicology and Pharmacology, School of Pharmacy, Kerman University of Medical Sciences, Kerman, Iran | ||
| 5Nutrition Research Center, Department of Clinical Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran | ||
| چکیده | ||
| Background: In women of reproductive age, polycystic ovary syndrome (PCOS) is a prevalent endocrine condition. This study assessed the effect of banana (Musa nana Lour.) peel extract and omega-3 on biochemical and histopathological features in rat model of PCOS. Methods: After PCOS induction, 56 adult female rats were randomly divided into seven groups. In group 1, healthy rats were given 20 mg/kg/day of normal saline. Group 2 comprised PCOS rats receiving saline as 20 mg/kg/day. Group 3 included rats with PCOS receiving 240 mg/kg/day omega-3. Group 4 consisted of rats with PCOS receiving 6 mL/kg/day of banana peel extract. Group 5 contained rats with PCOS receiving 12 mL/kg/day banana peel extract. Group 6 enrolled rats with PCOS taking 240 mg/kg/day omega-3 and 12 mL/kg/day banana peel extract. Group 7 consisted of rats with PCOS treated with 200 mg/kg/day metformin. Serum biochemical parameters and ovarian oxidative stress were evaluated together with histological assessment. The duration of treatment for all groups was 8 weeks. Results: Glycemic indices, serum triglyceride level, serum testosterone concentration, oxidative stress, and body weight significantly decreased. The ovarian tissue pathology in the animals treated with banana peel extract and omega-3 in comparison to the PCOS control group showed an improvement (p<0.05). Conclusion: Omega-3 supplementation with banana peel extract as an antioxidant may have beneficial effects on biochemical parameters and pathological demonstrations of PCOS. | ||
تازه های تحقیق | ||
Najmeh Hejazi (Google Scholar) | ||
| کلیدواژه‌ها | ||
| Banana؛ Omega 3؛ Polycystic ovary syndrome؛ Histopathology؛ Insulin resistance | ||
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