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Mirzaeiyan, Marziyeh, Akhavan, Ali, Amouheidari, Alireza, Adibi, Atoosa, Hemati, Simin, Etehadtavakol, Mahnaz, Khanahmad, Hossein, Shokrani, Parvaneh. (1404). Dosimetric and Radiobiological Comparison of Three-Dimensional Conformal Radiotherapy and Helical Tomotherapy in Whole Pelvic Radiotherapy of Prostate Cancer Patients. سامانه مدیریت نشریات علمی, 15(4), 333-340. doi: 10.31661/jbpe.v0i0.2301-1587
Marziyeh Mirzaeiyan; Ali Akhavan; Alireza Amouheidari; Atoosa Adibi; Simin Hemati; Mahnaz Etehadtavakol; Hossein Khanahmad; Parvaneh Shokrani. "Dosimetric and Radiobiological Comparison of Three-Dimensional Conformal Radiotherapy and Helical Tomotherapy in Whole Pelvic Radiotherapy of Prostate Cancer Patients". سامانه مدیریت نشریات علمی, 15, 4, 1404, 333-340. doi: 10.31661/jbpe.v0i0.2301-1587
Mirzaeiyan, Marziyeh, Akhavan, Ali, Amouheidari, Alireza, Adibi, Atoosa, Hemati, Simin, Etehadtavakol, Mahnaz, Khanahmad, Hossein, Shokrani, Parvaneh. (1404). 'Dosimetric and Radiobiological Comparison of Three-Dimensional Conformal Radiotherapy and Helical Tomotherapy in Whole Pelvic Radiotherapy of Prostate Cancer Patients', سامانه مدیریت نشریات علمی, 15(4), pp. 333-340. doi: 10.31661/jbpe.v0i0.2301-1587
Mirzaeiyan, Marziyeh, Akhavan, Ali, Amouheidari, Alireza, Adibi, Atoosa, Hemati, Simin, Etehadtavakol, Mahnaz, Khanahmad, Hossein, Shokrani, Parvaneh. Dosimetric and Radiobiological Comparison of Three-Dimensional Conformal Radiotherapy and Helical Tomotherapy in Whole Pelvic Radiotherapy of Prostate Cancer Patients. سامانه مدیریت نشریات علمی, 1404; 15(4): 333-340. doi: 10.31661/jbpe.v0i0.2301-1587

Dosimetric and Radiobiological Comparison of Three-Dimensional Conformal Radiotherapy and Helical Tomotherapy in Whole Pelvic Radiotherapy of Prostate Cancer Patients

Journal of Biomedical Physics and Engineering
مقاله 4، دوره 15، شماره 4 - شماره پیاپی 1، آبان 2025، صفحه 333-340    اصل مقاله (624.55 K)
نوع مقاله: Original Research
شناسه دیجیتال (DOI): 10.31661/jbpe.v0i0.2301-1587
نویسندگان
Marziyeh Mirzaeiyan1؛ Ali Akhavan2؛ Alireza Amouheidari3؛ Atoosa Adibi4؛ Simin Hemati2؛ Mahnaz Etehadtavakol1؛ Hossein Khanahmad5؛ Parvaneh Shokrani* 1
1Department of Medical Physics, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
2Department of Radiotherapy Oncology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
3Department of Radiation Oncology, Isfahan Milad Hospital, Isfahan, Iran
4Department of Radiology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
5Department of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
چکیده
Background: Modern radiotherapy techniques can destroy tumors with less harm to surrounding normal tissues. Normal Tissue Complication Probability (NTCP) models are useful to evaluate treatment plans.
Objective: This study aimed to use the Quantitative Analysis of Normal Tissue Effects in the Clinic (QUANTEC) program to evaluate dose-volume indicators and radiobiological parameters for complications of the rectum and bladder in prostate cancer patients undergoing pelvic radiotherapy.
Material and Methods: In this retrospective cross-sectional study, treatment planning information was gathered from 35 patients with pelvic lymph node involvement. Of these, 17 and 18 were treated using the three-dimensional Conformal Radiotherapy Technique (3D-CRT) and the Helical Tomotherapy (HT) technique, respectively. The Lyman-Kutcher-Burman and Relative Seriality models were used in conjunction with dose-volume histograms to calculate the NTCP values for the rectum and bladder.
Results: In the HT group compared to the 3D-CRT group, the values of D-Mean, V-40, V-50, V-60, and V-65 were lower for both the rectum and bladder. The NTCP values for grade 2 rectal bleeding, proctitis, and bladder toxicity were lower in the HT group. The dose-volume data of 67% of the HT patients satisfied all QUANTEC criteria, while only 30% of the 3D-CRT those met criteria. 
Conclusion: The QUANTEC criteria were satisfied for the rectum and bladder in the HT and 3D-CRT groups, except for V-50, V-60, and V-65 of the rectum in 3D-CRT patients. The NTCP values for both organs were lower in the HT group than in the 3D-CRT group.

تازه های تحقیق

Marziyeh Mirzaeiyan (Google Scholar)

Parvaneh Shokrani (Google Scholar)

کلیدواژه‌ها
Radiotherapy, Intensity-Modulated؛ Radiotherapy, Conformal؛ Prostate؛ Radiation Injuries؛ Rectum
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