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Shavandi, Mehrdad, Yazdani, Yasaman, Asar, Shirin, Mohammadi, Arash, Mohammadi-noori, Ehsan, Kiani, Amir. (1401). The Effect of Oral Administration of Silymarin on Serum Levels of Tumor Necrosis Factor-α and Interleukin-1ß in Patients with Rheumatoid Arthritis. سامانه مدیریت نشریات علمی, 19(4), 427-435. doi: 10.22034/iji.2022.90456.2007
Mehrdad Shavandi; Yasaman Yazdani; Shirin Asar; Arash Mohammadi; Ehsan Mohammadi-noori; Amir Kiani. "The Effect of Oral Administration of Silymarin on Serum Levels of Tumor Necrosis Factor-α and Interleukin-1ß in Patients with Rheumatoid Arthritis". سامانه مدیریت نشریات علمی, 19, 4, 1401, 427-435. doi: 10.22034/iji.2022.90456.2007
Shavandi, Mehrdad, Yazdani, Yasaman, Asar, Shirin, Mohammadi, Arash, Mohammadi-noori, Ehsan, Kiani, Amir. (1401). 'The Effect of Oral Administration of Silymarin on Serum Levels of Tumor Necrosis Factor-α and Interleukin-1ß in Patients with Rheumatoid Arthritis', سامانه مدیریت نشریات علمی, 19(4), pp. 427-435. doi: 10.22034/iji.2022.90456.2007
Shavandi, Mehrdad, Yazdani, Yasaman, Asar, Shirin, Mohammadi, Arash, Mohammadi-noori, Ehsan, Kiani, Amir. The Effect of Oral Administration of Silymarin on Serum Levels of Tumor Necrosis Factor-α and Interleukin-1ß in Patients with Rheumatoid Arthritis. سامانه مدیریت نشریات علمی, 1401; 19(4): 427-435. doi: 10.22034/iji.2022.90456.2007

The Effect of Oral Administration of Silymarin on Serum Levels of Tumor Necrosis Factor-α and Interleukin-1ß in Patients with Rheumatoid Arthritis

Iranian Journal of Immunology
دوره 19، شماره 4، اسفند 2022، صفحه 427-435    اصل مقاله (540.82 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22034/iji.2022.90456.2007
نویسندگان
Mehrdad Shavandi1، 2؛ Yasaman Yazdani3؛ Shirin Asar4؛ Arash Mohammadi5؛ Ehsan Mohammadi-noori6؛ Amir Kiani* 7
1Students’ Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran
2Department of Clinical Pharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
3Department of Epidemiology and Biostatistics, Schulich School of Medicine & Dentistry, Western University, London, Ontario, Canada
4Department of Internal Medicine, Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran
5School of Dentistry, Kermanshah University of Medical Sciences, Kermanshah, Iran
6Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran
7Regenerative Medicine Research Center (RMRC), Kermanshah University of Medical Sciences, Kermanshah, Iran
چکیده
Background: Rheumatoid Arthritis (RA) is a systemic chronic autoimmune disease. Several inflammatory agents play key roles in RA pathogenesis, among which tumor necrosis factor-alpha (TNF-α) and interleukin 1 beta (IL-1β) are of great importance. Silymarin is a potent anti-oxidant extracted from Silybummarianum L. seeds.
Objective: To study the effect of silymarin on serum levels of TNF-α and IL-1β in patients with RA.
Methods: Patients with stable RA received 140 mg of silymarin, 3 times a day, for 3 months. Serum samples were collected before and after the treatment. Both TNF-α and IL-1β serum levels were measured by ELISA.
Results: 42 patients (14.3% male, and 85.7% female, with a mean age of 47.59±12.8 years old) completed the treatment course. There was no significant difference in the overall mean concentration of either TNF-α (p=0.14) or IL-1β (p=0.27) in all 42 patients after the treatment with silymarin.
Conclusion: The addition of silymarin to the treatment regimen of patients with stable RA has no significant effect on the serum levels of TNF-α and IL-1β, however, this study needs further evaluation with a larger sample size.
کلیدواژه‌ها
IL-1β؛ Rheumatoid Arthritis؛ Silymarin؛ TNF-α
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