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Li, Defu, Li, Hongbing, Li, Wei, Zhu, Tingting. (1401). Anti-Ro52 Antibody as a Protective Factor for Pulmonary Fibrosis in Primary Sjögren's Syndrome. سامانه مدیریت نشریات علمی, 19(2), 161-171. doi: 10.22034/iji.2022.91412.2077
Defu Li; Hongbing Li; Wei Li; Tingting Zhu. "Anti-Ro52 Antibody as a Protective Factor for Pulmonary Fibrosis in Primary Sjögren's Syndrome". سامانه مدیریت نشریات علمی, 19, 2, 1401, 161-171. doi: 10.22034/iji.2022.91412.2077
Li, Defu, Li, Hongbing, Li, Wei, Zhu, Tingting. (1401). 'Anti-Ro52 Antibody as a Protective Factor for Pulmonary Fibrosis in Primary Sjögren's Syndrome', سامانه مدیریت نشریات علمی, 19(2), pp. 161-171. doi: 10.22034/iji.2022.91412.2077
Li, Defu, Li, Hongbing, Li, Wei, Zhu, Tingting. Anti-Ro52 Antibody as a Protective Factor for Pulmonary Fibrosis in Primary Sjögren's Syndrome. سامانه مدیریت نشریات علمی, 1401; 19(2): 161-171. doi: 10.22034/iji.2022.91412.2077

Anti-Ro52 Antibody as a Protective Factor for Pulmonary Fibrosis in Primary Sjögren's Syndrome

Iranian Journal of Immunology
مقاله 4، دوره 19، شماره 2، شهریور 2022، صفحه 161-171    اصل مقاله (1.4 M)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22034/iji.2022.91412.2077
نویسندگان
Defu Li1، 2؛ Hongbing Li3؛ Wei Li1؛ Tingting Zhu* 2
1Department of Radiology, Fuyong People's Hospital of Shenzhen Baoan, Shenzhen 518103, China
2Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
3Department of Radiology, Fuyong People's Hospital of Shenzhen Baoan, Shenzhen 518103, China
چکیده
Background: Pulmonary fibrosis is common in primary Sjögren's syndrome (pSS)-related interstitial lung disease (ILD). However, research is lacking on the diagnostic immunological examination of pSS-related pulmonary fibrosis. Particularly, the value of detecting anti-Ro52 antibody in pulmonary fibrosis is unclear. Objective: To evaluate the potential diagnostic value of anti-SSA, anti-SSB, and anti-Ro52 autoantibodies as markers of pSS-related pulmonary fibrosis. Methods: One-hundred seventy-nine patients with pSS were analyzed retrospectively at our hospital. They were divided into the fibrosis and non-fibrosis groups. Pulmonary fibrosis was classified as mild, moderate, or severe based on the patients' computed tomography (CT) findings. Laboratory examinations, including anti-SSA, anti-SSB, and anti-Ro52 antibody evaluations, were performed. The influencing factors of pulmonary fibrosis were analyzed using logistic regression. Results: Chest CT revealed pulmonary fibrosis in 45 patients with pSS (25.1%). The positive rates of anti-SSA and anti-Ro52 antibodies in the fibrosis group were lower than in the non-fibrosis group (P=0.04, P=0.001). The frequency of anti-Ro52 antibody showed no significant differences between mild-to-moderate (53.8%) and severe (47.3%) pulmonary fibrosis. The anti-Ro52 antibody was identified as a potentially protective factor against pSS (P=0.041). Conclusions: Patients with pSS and pulmonary fibrosis had a low frequency of anti-SSA and anti-Ro52 antibodies. In patients with pSS and negative anti-Ro52 antibody, a chest CT is recommended to further understand the patients' condition.
کلیدواژه‌ها
Anti-Ro52 antibody؛ Computed tomography؛ Primary Sjögren’s syndrome؛ Pulmonary fibrosis
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