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Miri, Niloufar Sadat, Saadat, Payam, Azadmehr, Abbas, Oladnabi, Morteza, Daraei, Abdolreza. (1399). Toll-Like Receptor (TLR)-9 rs352140 Polymorphism is an Immunopathology Protective Factor in Parkinson's Disease in the Northern Iranian Population. سامانه مدیریت نشریات علمی, 17(4), 313-323. doi: 10.22034/iji.2020.87454.1803
Niloufar Sadat Miri; Payam Saadat; Abbas Azadmehr; Morteza Oladnabi; Abdolreza Daraei. "Toll-Like Receptor (TLR)-9 rs352140 Polymorphism is an Immunopathology Protective Factor in Parkinson's Disease in the Northern Iranian Population". سامانه مدیریت نشریات علمی, 17, 4, 1399, 313-323. doi: 10.22034/iji.2020.87454.1803
Miri, Niloufar Sadat, Saadat, Payam, Azadmehr, Abbas, Oladnabi, Morteza, Daraei, Abdolreza. (1399). 'Toll-Like Receptor (TLR)-9 rs352140 Polymorphism is an Immunopathology Protective Factor in Parkinson's Disease in the Northern Iranian Population', سامانه مدیریت نشریات علمی, 17(4), pp. 313-323. doi: 10.22034/iji.2020.87454.1803
Miri, Niloufar Sadat, Saadat, Payam, Azadmehr, Abbas, Oladnabi, Morteza, Daraei, Abdolreza. Toll-Like Receptor (TLR)-9 rs352140 Polymorphism is an Immunopathology Protective Factor in Parkinson's Disease in the Northern Iranian Population. سامانه مدیریت نشریات علمی, 1399; 17(4): 313-323. doi: 10.22034/iji.2020.87454.1803

Toll-Like Receptor (TLR)-9 rs352140 Polymorphism is an Immunopathology Protective Factor in Parkinson's Disease in the Northern Iranian Population

Iranian Journal of Immunology
مقاله 6، دوره 17، شماره 4، اسفند 2020، صفحه 313-323    اصل مقاله (252.97 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22034/iji.2020.87454.1803
نویسندگان
Niloufar Sadat Miri1؛ Payam Saadat2؛ Abbas Azadmehr* 1؛ Morteza Oladnabi3؛ Abdolreza Daraei1
1Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran
2Mobility Impairment Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.
3Gorgan Congenital Malformations Research Center, Golestan University of Medical Sciences, Gorgan, Iran
چکیده
Background: Neuroinflammation and immunopathology in Parkinson's disease (PD) are believed to be associated with genetic and environmental factors. Objective: We conducted the current study to evaluate the Toll-like receptors (TLR4 and TLR9) genes polymorphism in patients with Parkinson's disease in northern Iran. Methods: We extracted DNA from peripheral blood samples of 100 sporadic cases of Parkinson's disease and 100 healthy-matched controls with the mean age of 69.98 and 71.94 years, respectively. Subsequently, single-nucleotide polymorphisms (SNPs) of TLR4 and TLR9 were genotyped using restriction fragment length polymorphism-polymerase chain reaction (RFLP-PCR). Results were confirmed employing Sanger sequencing. For the analysis of our data, we used SNPStats and SPSS 22 software. Results: Our findings indicated that the allele distribution for rs352140 of TLR9 gene was significantly different in the PD group compared with the healthy controls (p=0.02). Moreover, rs352140 T allele was observed to be correlated with PD reduced risk (TT + TC vs. CC). The dominant rs352140 model was approved as the most acceptable inheritance model for fitting the data (OR 0.41, 95% CI 0.23-0.75, p=0.0031). Additionally, haplotype analysis revealed a significant correlation between TLR9 polymorphisms and Parkinson's disease. Conclusion: The results of this study indicated that rs352140T of TLR9 gene was a protective factor in Parkinson's disease. Furthermore, this SNP could be regarded as a prognostic factor. However, this conclusion should be confirmed by further investigations.
کلیدواژه‌ها
Parkinson’s Disease؛ Single-Nucleotide Polymorphisms (SNPs)؛ Toll-Like Receptors 4؛ Toll-Like Receptors 9
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