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Yousefian, Bahram, Firoozabadi, Seyed Mohammad, Mokhtari-Dizaji, Manijhe. (1401). Magnetoporation: New Method for Permeabilization of Cancerous Cells to Hydrophilic Drugs. سامانه مدیریت نشریات علمی, 12(2), 205-210. doi: 10.31661/jbpe.v0i0.1256
Bahram Yousefian; Seyed Mohammad Firoozabadi; Manijhe Mokhtari-Dizaji. "Magnetoporation: New Method for Permeabilization of Cancerous Cells to Hydrophilic Drugs". سامانه مدیریت نشریات علمی, 12, 2, 1401, 205-210. doi: 10.31661/jbpe.v0i0.1256
Yousefian, Bahram, Firoozabadi, Seyed Mohammad, Mokhtari-Dizaji, Manijhe. (1401). 'Magnetoporation: New Method for Permeabilization of Cancerous Cells to Hydrophilic Drugs', سامانه مدیریت نشریات علمی, 12(2), pp. 205-210. doi: 10.31661/jbpe.v0i0.1256
Yousefian, Bahram, Firoozabadi, Seyed Mohammad, Mokhtari-Dizaji, Manijhe. Magnetoporation: New Method for Permeabilization of Cancerous Cells to Hydrophilic Drugs. سامانه مدیریت نشریات علمی, 1401; 12(2): 205-210. doi: 10.31661/jbpe.v0i0.1256

Magnetoporation: New Method for Permeabilization of Cancerous Cells to Hydrophilic Drugs

Journal of Biomedical Physics and Engineering
مقاله 11، دوره 12، شماره 2، تیر 2022، صفحه 205-210    اصل مقاله (568.69 K)
نوع مقاله: Original Research
شناسه دیجیتال (DOI): 10.31661/jbpe.v0i0.1256
نویسندگان
Bahram Yousefian1؛ Seyed Mohammad Firoozabadi* 2؛ Manijhe Mokhtari-Dizaji2
1PhD, Department of Radiology, Faculty of Allied Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
2PhD, Department of Medical Physics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
چکیده
Background: In the present study, we investigated the application of pulsed magnetic field (MF) (3.5 T, 1 Hz, 8 square-wave/160 µs) permeabilization on murine breast adenocarcinoma cells when administering bleomycin (BLM) in vivo.
Objective: This cross-over study aims to find a noninvasive method to facilitate penetration of hydrophilic anti-cancer drugs through the cancerous cells membrane into the cytosoll in order to minimize the side effects of the chemotherapy treatments of tumors.
Material and Methods: In this cross-over study, a total of 50 female Balb/c mice were tumorized via homograft. After about 2 weeks, magnetic pulses (3.5 T, 1 Hz, 8 square-wave/160 µs) were applied to tumor-bearing mice 3 min after intratumoral BLM solution injection. Tumor volume was measured every 48 h during 22 days.
Results: The results showed that the difference between the BLM plus 3.5 T MF group versus the sham control or sham MF groups was significant. Uptake of BLM molecules by tumoral cells in the BLM plus 3.5 T MF group versus the BLM control group was 7- folds higher that this result was statistically insignificant (p <0.05, SEM=266.8676, analysis of variance).
Conclusion: Significant cell permeabilization to BLM requires greater MF strength or exposure time. Further investigation is necessary.
کلیدواژه‌ها
Chemotherapy؛ Magnetic Fields؛ Permeabilization؛ In Vivo؛ Bleomycin؛ Balb/C؛ Adenocarcinoma
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مراجع
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