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Shiri, Zahra, Mansouri, Reza, Haghshenas, Mohammad Reza, Talei, Abdolrasoul, Erfani, Nasrollah. (1398). FOXP3 Genetic Variation at Position -2383 C/T (rs3761549) in Patients with Breast Cancer. سامانه مدیریت نشریات علمی, 10(4), 299-304. doi: 10.30476/mejc.2019.78638.
Zahra Shiri; Reza Mansouri; Mohammad Reza Haghshenas; Abdolrasoul Talei; Nasrollah Erfani. "FOXP3 Genetic Variation at Position -2383 C/T (rs3761549) in Patients with Breast Cancer". سامانه مدیریت نشریات علمی, 10, 4, 1398, 299-304. doi: 10.30476/mejc.2019.78638.
Shiri, Zahra, Mansouri, Reza, Haghshenas, Mohammad Reza, Talei, Abdolrasoul, Erfani, Nasrollah. (1398). 'FOXP3 Genetic Variation at Position -2383 C/T (rs3761549) in Patients with Breast Cancer', سامانه مدیریت نشریات علمی, 10(4), pp. 299-304. doi: 10.30476/mejc.2019.78638.
Shiri, Zahra, Mansouri, Reza, Haghshenas, Mohammad Reza, Talei, Abdolrasoul, Erfani, Nasrollah. FOXP3 Genetic Variation at Position -2383 C/T (rs3761549) in Patients with Breast Cancer. سامانه مدیریت نشریات علمی, 1398; 10(4): 299-304. doi: 10.30476/mejc.2019.78638.

FOXP3 Genetic Variation at Position -2383 C/T (rs3761549) in Patients with Breast Cancer

Middle East Journal of Cancer
مقاله 3، دوره 10، شماره 4 - شماره پیاپی 40، دی 2019، صفحه 299-304    اصل مقاله (582.89 K)
نوع مقاله: Original Article(s)
شناسه دیجیتال (DOI): 10.30476/mejc.2019.78638.
نویسندگان
Zahra Shiri1؛ Reza Mansouri1، 2؛ Mohammad Reza Haghshenas3؛ Abdolrasoul Talei4، 5؛ Nasrollah Erfani* 6
1Department of Immunology, Faculty of Medicine, International Branch of Shahid Sadoughi University of Medical Sciences, Yazd, Iran
2Hematology and Oncology Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
3Shiraz Institute for Cancer Research, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
4Breast Disease Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
5Department of Surgery, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
6Department of Immunology and Shiraz Institute for Cancer Research, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
چکیده
Background:We investigated the possibility of an association between the C-2383T polymorphism (rs3761549) in the promoter region of the FOXP3 gene with breast cancer.
Methods: The study groups consisted of 250 women diagnosed with breast cancer (case group) and 250 healthy women (control group). Polymerase chain reactionrestriction fragment length polymorphism was performed for genotyping.
Results: Breast cancer cases had a C allele frequency of 455 (91%) and T allele frequency of 45 (9%). The control group had a C allele frequency of 468 (93.6%) and 32 (6.4%) for the T allele. The CC genotype was present in 206 (82.4%) patients, 43 (17.2%) patients had the CT genotype, and the TT genotype was observed in 1 (0.4%) patient. In the control group, 219 (87.6%) had the CC genotype, whereas 30 (12%) had the CT genotype, and 1 (0.4%) had the TT genotype. Statistical analysis revealed no significant differences in the distribution of alleles and genotypes between patients and controls (P>0.05). There was no significant association between genotype distribution and patients' clinicopathological factors.
Conclusion: Our results do not support an association between the FOXP3 -2383 C/T polymorphism and breast cancer in a population from southern Iran.
کلیدواژه‌ها
Breast cancer؛ FOXP3 gene؛ Single nucleotide polymorphism؛ PCR-RFLP
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