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Hormozi, Asef, Zarifkar, Asadollah, Rostami, Bahar, Naghibalhossaini, Fakhraddin. (1398). An Experimental Study on Spinal Cord µ-Opioid and α2-Adrenergic Receptors mRNA Expression Following Stress-Induced Hyperalgesia in Male Rats. سامانه مدیریت نشریات علمی, 44(5), 397-405. doi: 10.30476/ijms.2019.44958
Asef Hormozi; Asadollah Zarifkar; Bahar Rostami; Fakhraddin Naghibalhossaini. "An Experimental Study on Spinal Cord µ-Opioid and α2-Adrenergic Receptors mRNA Expression Following Stress-Induced Hyperalgesia in Male Rats". سامانه مدیریت نشریات علمی, 44, 5, 1398, 397-405. doi: 10.30476/ijms.2019.44958
Hormozi, Asef, Zarifkar, Asadollah, Rostami, Bahar, Naghibalhossaini, Fakhraddin. (1398). 'An Experimental Study on Spinal Cord µ-Opioid and α2-Adrenergic Receptors mRNA Expression Following Stress-Induced Hyperalgesia in Male Rats', سامانه مدیریت نشریات علمی, 44(5), pp. 397-405. doi: 10.30476/ijms.2019.44958
Hormozi, Asef, Zarifkar, Asadollah, Rostami, Bahar, Naghibalhossaini, Fakhraddin. An Experimental Study on Spinal Cord µ-Opioid and α2-Adrenergic Receptors mRNA Expression Following Stress-Induced Hyperalgesia in Male Rats. سامانه مدیریت نشریات علمی, 1398; 44(5): 397-405. doi: 10.30476/ijms.2019.44958

An Experimental Study on Spinal Cord µ-Opioid and α2-Adrenergic Receptors mRNA Expression Following Stress-Induced Hyperalgesia in Male Rats

Iranian Journal of Medical Sciences
مقاله 5، دوره 44، شماره 5، آذر 2019، صفحه 397-405    اصل مقاله (1.04 M)
نوع مقاله: Original Article(s)
شناسه دیجیتال (DOI): 10.30476/ijms.2019.44958
نویسندگان
Asef Hormozi1؛ Asadollah Zarifkar* 2؛ Bahar Rostami1؛ Fakhraddin Naghibalhossaini3
1Department of Physiology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
2Department of Physiology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran; and Shiraz Neuroscience Research Center, Shiraz University of Medical Sciences, Shiraz, Iran; and Department of Neuroscience, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran
3Department of Biochemistry, Shiraz University of Medical Sciences, School of Medicine, Shiraz, Iran; and Autoimmune Research Center, Shiraz University of Medical Sciences, School of Medicine, Shiraz, Iran
چکیده
Background: Intense stress can change pain perception and induce hyperalgesia; a phenomenon called stress-induced hyperalgesia (SIH). However, the neurobiological mechanism of this effect remains unclear. The present study aimed to investigate the effect of the spinal cord µ-opioid receptors (MOR) and α2-adrenergic receptors (α2-AR) on pain sensation in rats with SIH. Methods: Eighteen Sprague-Dawley male rats, weighing 200-250 g, were randomly divided into two groups (n=9 per group), namely the control and stress group. The stress group was evoked by random 1-hour daily foot-shock stress (0.8 mA for 10 seconds, 1 minute apart) for 3 weeks using a communication box. The tail-flick and formalin tests were performed in both groups on day 22. The real-time RT-PCR technique was used to observe MOR and α2-AR mRNA levels at the L4-L5 lumbar spinal cord. Statistical analysis was performed using the GraphPad Prism 5 software (San Diego, CA, USA). Student’s t test was applied for comparisons between the groups. P
کلیدواژه‌ها
Stress؛ Hyperalgesia؛ Spinal cord؛ Receptors, opioid, mu؛ Adrenergic alpha-2 receptor antagonists
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