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Sağmak Tartar, Ayşe, Ozer Balın, Şafak, Akbulut, Ayhan, Yardım, Meltem, Aydın, Suleyman. (1398). Roles of Dermcidin, Salusin-α, Salusin-β and TNF-α in the Pathogenesis of Human Brucellosis. سامانه مدیریت نشریات علمی, 16(2), 182-189. doi: 10.22034/iji.2019.80261
Ayşe Sağmak Tartar; Şafak Ozer Balın; Ayhan Akbulut; Meltem Yardım; Suleyman Aydın. "Roles of Dermcidin, Salusin-α, Salusin-β and TNF-α in the Pathogenesis of Human Brucellosis". سامانه مدیریت نشریات علمی, 16, 2, 1398, 182-189. doi: 10.22034/iji.2019.80261
Sağmak Tartar, Ayşe, Ozer Balın, Şafak, Akbulut, Ayhan, Yardım, Meltem, Aydın, Suleyman. (1398). 'Roles of Dermcidin, Salusin-α, Salusin-β and TNF-α in the Pathogenesis of Human Brucellosis', سامانه مدیریت نشریات علمی, 16(2), pp. 182-189. doi: 10.22034/iji.2019.80261
Sağmak Tartar, Ayşe, Ozer Balın, Şafak, Akbulut, Ayhan, Yardım, Meltem, Aydın, Suleyman. Roles of Dermcidin, Salusin-α, Salusin-β and TNF-α in the Pathogenesis of Human Brucellosis. سامانه مدیریت نشریات علمی, 1398; 16(2): 182-189. doi: 10.22034/iji.2019.80261

Roles of Dermcidin, Salusin-α, Salusin-β and TNF-α in the Pathogenesis of Human Brucellosis

Iranian Journal of Immunology
مقاله 9، دوره 16، شماره 2، شهریور 2019، صفحه 182-189    اصل مقاله (785.47 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22034/iji.2019.80261
نویسندگان
Ayşe Sağmak Tartar* 1؛ Şafak Ozer Balın1؛ Ayhan Akbulut1؛ Meltem Yardım2؛ Suleyman Aydın2
1Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Firat University, Elazig, Turkey
2Department of Biochemistry, Faculty of Medicine, Firat University, Elazig, Turkey
چکیده
Background:Brucella spp. are facultative intracellular pathogens that can cause chronic infections in many tissues and organs. Objectives: To investigate serum dermcidin, salusin-alpha, salusin-beta and TNF-alpha levels and their correlation with each other in patients with acute brucellosis. Methods: From 50 patients hospitalized upon diagnosis of acute brucellosis, blood samples were collected and dermcidin, salusin-alpha, salusin-beta and TNF-alpha levels in serum samples were measured using an ELISA assay. The control group included 40 volunteers. Results: Brucellosis group had significantly lower plasma dermcidin, salusin- alpha, salusin-beta levels compared to the healthy control group (respectively p:0.008, p<0.001, p<0.001). Moreover, Brucellosis group had significantly higher plasma TNF-alpha levels comparisons with the controls (p=0.002). In the examination of the correlation between TNF-alpha and dermcidin, salusin-alpha and salusin-beta in the brucellosis group, only a negative correlation was found between salusin-beta and TNF-alpha. In the control group, there was a positive and statistically significant correlation between salusin-beta and TNF-alpha. Conclusion: Dermcidin, salusin-alpha, and, particularly salusin-beta levels are important in Brucella pathogenesis. The paradoxical correlation between TNF-alpha and salusin-beta in patients with brucellosis and control group is remarkable. However, there is a need for extensive studies conducted with more patients to further elucidate this topic.
کلیدواژه‌ها
Brucellosis؛ Dermcidin؛ Salusin-Alpha؛ Salusin-Beta؛ TNF-Alpha
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