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Fakhari, Shohreh, Bashiri, Hamed, Ghaderi, Bayazid, Tari, Kaveh, Jalili, Ali. (1398). CD93 is Selectively Expressed on Human Myeloma Cells but Not on B Lymphocytes. سامانه مدیریت نشریات علمی, 16(2), 142-150. doi: 10.22034/iji.2019.80257
Shohreh Fakhari; Hamed Bashiri; Bayazid Ghaderi; Kaveh Tari; Ali Jalili. "CD93 is Selectively Expressed on Human Myeloma Cells but Not on B Lymphocytes". سامانه مدیریت نشریات علمی, 16, 2, 1398, 142-150. doi: 10.22034/iji.2019.80257
Fakhari, Shohreh, Bashiri, Hamed, Ghaderi, Bayazid, Tari, Kaveh, Jalili, Ali. (1398). 'CD93 is Selectively Expressed on Human Myeloma Cells but Not on B Lymphocytes', سامانه مدیریت نشریات علمی, 16(2), pp. 142-150. doi: 10.22034/iji.2019.80257
Fakhari, Shohreh, Bashiri, Hamed, Ghaderi, Bayazid, Tari, Kaveh, Jalili, Ali. CD93 is Selectively Expressed on Human Myeloma Cells but Not on B Lymphocytes. سامانه مدیریت نشریات علمی, 1398; 16(2): 142-150. doi: 10.22034/iji.2019.80257

CD93 is Selectively Expressed on Human Myeloma Cells but Not on B Lymphocytes

Iranian Journal of Immunology
مقاله 5، دوره 16، شماره 2، شهریور 2019، صفحه 142-150    اصل مقاله (922.74 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22034/iji.2019.80257
نویسندگان
Shohreh Fakhari1، 2؛ Hamed Bashiri1؛ Bayazid Ghaderi1؛ Kaveh Tari1؛ Ali Jalili* 1، 2
1Cancer and Immunology Research Center, Kurdistan University of Medical Sciences, Sanandaj, Iran
2Department of Immunology, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran
چکیده
Background: CD93 has originally been known as a C1q receptor, and many studies have demonstrated that CD93 is expressed on hematopoietic stem cells, B cell progenitors, myeloid and monocytic cells. Moreover, CD93 is shown to be expressed on long-lived plasma cells, and CD93 deficient-mice display an impairment in plasma cell development. Objective: To investigate the expression of CD93 on multiple myeloma (MM) cells. Methods: Human MM and B cell lines were cultured, and the expression of CD93 was examined on these cells by quantitative Reverse Transcription Polymerase Chain Reaction (qRT-PCR) and Fluorescence Activated Cell Sorting (FACS). In addition, CD19+ primary B cells and CD19-/CD138+ primary MM cells were isolated by MACS columns, and CD93 expression was further analyzed on these cells. Results: qRT-PCR data showed that CD93 expression at mRNA level was much higher in MM cell lines compared with B cell lines. In addition, MM cell lines expressed a higher amount of surface CD93 at protein level compared with B cell lines. More importantly, CD93 expression was significantly higher in CD19-/CD138+ primary MM cells than in CD19+ primary B cells isolated from the bone marrow of patients with MM. Conclusion: We demonstrated that CD93 is expressed on myeloma cells and, that CD93 could play a key role in the pathogenesis of MM. Further studies are necessary to explore this possible role.
کلیدواژه‌ها
C1q؛ CD93؛ Multiple Myeloma
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