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Cytotoxic Effect of Luteolin on Human Colorectal Cancer Cell Line (HCT-15): Crucial Involvement of Reactive Oxygen Species | ||
| Middle East Journal of Cancer | ||
| مقاله 5، دوره 4، شماره 4، دی 2013، صفحه 175-180 اصل مقاله (237.33 K) | ||
| نوع مقاله: Brief Communication | ||
| نویسندگان | ||
| Ashok Kumar Pandurangan* ؛ Sudhandiran Ganapasam | ||
| Department of Biochemistry, University of Madras, Chennai, Tamil Nadu, India | ||
| چکیده | ||
| Background: Colorectal cancer, a major health concern worldwide, is the third most common form of cancer and second leading cause of cancer-related deaths. The flavonoids are naturally occurring diphenylpropanoids ubiquitous in plant foods and important components of the human diet. Luteolin, a bioflavonoid, possesses many beneficial effects including antioxidant, anti-inflammatory, anti-allergic activities. Methods:We used the HCT-15 colon adenocarcinoma cell line in this study. Cells were treated with luteolin (100 µM).Results: Membrane damage markers such as alkaline phosphatase and lactate dehydrogenase were analyzed in a time-dependent manner. Luteolin increased reactive oxygen species in a time-dependent manner. DNA damage, a hallmark of apoptosis, was induced by luteolin as analyzed by agarose gel electrophoresis.Conclusion: Luteolin acts as a potential cytotoxic agent that can be used to treat colorectal cancer. | ||
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