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Robinson, Sara, Soliman, Amr, Karkouri, Mehdi, Omer, Hoda, Greenson, Joel. (1388). Differences in Molecular Pathologic Characteristics of Pancreatic Adenocarcinoma between Egyptian and Moroccan Patients. سامانه مدیریت نشریات علمی, 1(1), 27-36.
Sara Robinson; Amr S. Soliman; Mehdi Karkouri; Hoda Gad Omer; Joel F. Greenson. "Differences in Molecular Pathologic Characteristics of Pancreatic Adenocarcinoma between Egyptian and Moroccan Patients". سامانه مدیریت نشریات علمی, 1, 1, 1388, 27-36.
Robinson, Sara, Soliman, Amr, Karkouri, Mehdi, Omer, Hoda, Greenson, Joel. (1388). 'Differences in Molecular Pathologic Characteristics of Pancreatic Adenocarcinoma between Egyptian and Moroccan Patients', سامانه مدیریت نشریات علمی, 1(1), pp. 27-36.
Robinson, Sara, Soliman, Amr, Karkouri, Mehdi, Omer, Hoda, Greenson, Joel. Differences in Molecular Pathologic Characteristics of Pancreatic Adenocarcinoma between Egyptian and Moroccan Patients. سامانه مدیریت نشریات علمی, 1388; 1(1): 27-36.

Differences in Molecular Pathologic Characteristics of Pancreatic Adenocarcinoma between Egyptian and Moroccan Patients

Middle East Journal of Cancer
مقاله 5، دوره 1، شماره 1، فروردین 2010، صفحه 27-36    اصل مقاله (102.37 K)
نوع مقاله: Original Article(s)
نویسندگان
Sara Robinson1؛ Amr S. Soliman* 1؛ Mehdi Karkouri2؛ Hoda Gad Omer3؛ Joel F. Greenson4
1Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, Michigan, USA
2Department of Pathology, Mohammed V University, Casablanca, Morocco
3Department of Pathology, Tanta Cancer Center, Tanta, Egypt
4Department of Pathology, University of Michigan School of Medicine, Ann Arbor, Michigan, USA
چکیده
Introduction: Pancreatic cancer has not been well studied, especially in developing countries.Materials and Methods: We studied the variations in genetic mutations in pancreatic adenocarcinoma between Moroccan and Egyptian populations. The molecular pathology of 30 tumors from a large hospital in Casablanca, Morocco were examined and compared with the findings of 44 tumors from the Gharbiah Governate in Egypt. K-ras mutations in codons12 and 13 in addition to p53 mutations in exons 5-8 were evaluated.Results: Overall, differences in the rates of K-ras mutations were not statistically significant (48.00 and 34.09%, respectively); however differences in rates of p53 mutations were statistically significant with p53 mutations more common in Moroccan tumors than in Egyptian tumors (46.67 and 16.28%, respectively). GTmutations of the K-ras gene were most commonly seen Egyptian tumors, whereas GAmutations were the most common type of mutations in Moroccan tumors. Logistic regression analysis showed that a p53 mutation in any exon as well as a p53 mutation in exon 5 predicted the country of residence and those mutations occurred more frequently in Moroccan patients. Conclusion: Our study shows that differences exist within the Arab population in the molecular pathology of both the K-ras and p53 genes. Further studies are necessary to clarify the differences in molecular pathways of pancreatic cancer in the Middle East and to investigate the role of environmental and/or genetic factors related to those pathways.
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