LinkedIn

 آمار

تعداد نشریات20
تعداد شماره‌ها1,191
تعداد مقالات10,861
تعداد مشاهده مقاله73,141,402
تعداد دریافت فایل اصل مقاله13,103,240
Eldeeb, Hany, Abozeed, Waleed, Hunter, David, Shaikh, Shaffi. (1390). Neoadjuvant Chemotherapy in Esophageal Cancer: Single Institution Experience. سامانه مدیریت نشریات علمی, 2(Issue 3-4), 105-112.
Hany Eldeeb; Waleed Abozeed; David Hunter; Shaffi Shaikh. "Neoadjuvant Chemotherapy in Esophageal Cancer: Single Institution Experience". سامانه مدیریت نشریات علمی, 2, Issue 3-4, 1390, 105-112.
Eldeeb, Hany, Abozeed, Waleed, Hunter, David, Shaikh, Shaffi. (1390). 'Neoadjuvant Chemotherapy in Esophageal Cancer: Single Institution Experience', سامانه مدیریت نشریات علمی, 2(Issue 3-4), pp. 105-112.
Eldeeb, Hany, Abozeed, Waleed, Hunter, David, Shaikh, Shaffi. Neoadjuvant Chemotherapy in Esophageal Cancer: Single Institution Experience. سامانه مدیریت نشریات علمی, 1390; 2(Issue 3-4): 105-112.

Neoadjuvant Chemotherapy in Esophageal Cancer: Single Institution Experience

Middle East Journal of Cancer
مقاله 3، دوره 2، Issue 3-4، مهر 2011، صفحه 105-112    اصل مقاله (294.53 K)
نوع مقاله: Original Article(s)
نویسندگان
Hany Eldeeb* 1؛ Waleed Abozeed2؛ David Hunter3؛ Shaffi Shaikh4
1Oncology Centre, Northampton General Hospital, Cliftonville, Northampton, NN1 5BD, United Kingdom
2Department of Clinical Oncology and Nuclear Medicine, Mansoura University Hospital, Mansoura, Egypt
3Department of Surgery, Northampton General Hospital, Cliftonville, Northampton, NN1 5BD, United Kingdom
4Department of Family and Community Medicine, College of Medicine, King Saud University, Saudi Arabia
چکیده
Background: Esophageal cancer is a major clinical problem that has a generally poor prognosis. As a result, there has been interest in combining surgery with neoadjuvant chemotherapy in an attempt to improve clinical outcomes. Evidence for clinical benefit from preoperative chemotherapy exists but it is not clear which patients (stage, tumor location, and histology) will benefit the most from this preoperative treatment.Methods: This study retrospectively analyzed the outcome of 71 patients with operable esophageal carcinoma treated at Northamptonshire Oncology Centre, UK from January 2001 until July 2008. Patients were treated with two cycles of neoadjuvant chemotherapy followed by surgery. Data were analyzed by Kaplan-Meier plots, Cox regression modeling and chi-squared test.Results:Median patient’s age was 64 years. Male patients represented 83% of the cases. Of patients, 63% had an ECOG performance status of 1. Surgical resection was done for 63 (88.7%) patients. Two year overall survival in this cohort was 5.6%. Univariate analysis identified only surgical resection to be associated with better prognosis (P<0.0001). Multivariate analysis identified surgical resection (P<0.0001) and pathology type (P=0.007) to be the significant independent prognostic factors for survival.Conclusion: In this retrospective study, survival data for operable esophageal cancer is poor despite the use of neoadjuvant chemotherapy. Lack of a dedicated upper gastrointestinal surgeon and unavailability of PET scan staging during the study period might have attributed to the poor outcome.
آمار
تعداد مشاهده مقاله: 4,060
تعداد دریافت فایل اصل مقاله: 1,252


سامانه مدیریت نشریات علمی. قدرت گرفته از سیناوب