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Modanloo, Hamed, Eftekharıan, Hamıdreza, Arabiun, Hamidreza. (1397). Postoperative Pain Management after Impacted Third Molar Surgery with Preoperative Oral Lamotrigine, a Randomized, Double-blind, Placebo-Controlled Trial. سامانه مدیریت نشریات علمی, 19(3), 189-196. doi: 10.30476/dentjods.2018.41811
Hamed Modanloo; Hamıdreza Eftekharıan; Hamidreza Arabiun. "Postoperative Pain Management after Impacted Third Molar Surgery with Preoperative Oral Lamotrigine, a Randomized, Double-blind, Placebo-Controlled Trial". سامانه مدیریت نشریات علمی, 19, 3, 1397, 189-196. doi: 10.30476/dentjods.2018.41811
Modanloo, Hamed, Eftekharıan, Hamıdreza, Arabiun, Hamidreza. (1397). 'Postoperative Pain Management after Impacted Third Molar Surgery with Preoperative Oral Lamotrigine, a Randomized, Double-blind, Placebo-Controlled Trial', سامانه مدیریت نشریات علمی, 19(3), pp. 189-196. doi: 10.30476/dentjods.2018.41811
Modanloo, Hamed, Eftekharıan, Hamıdreza, Arabiun, Hamidreza. Postoperative Pain Management after Impacted Third Molar Surgery with Preoperative Oral Lamotrigine, a Randomized, Double-blind, Placebo-Controlled Trial. سامانه مدیریت نشریات علمی, 1397; 19(3): 189-196. doi: 10.30476/dentjods.2018.41811

Postoperative Pain Management after Impacted Third Molar Surgery with Preoperative Oral Lamotrigine, a Randomized, Double-blind, Placebo-Controlled Trial

Journal of Dentistry
مقاله 4، دوره 19، شماره 3، آذر 2018، صفحه 189-196    اصل مقاله (243.75 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.30476/dentjods.2018.41811
نویسندگان
Hamed Modanloo1؛ Hamıdreza Eftekharıan* 2؛ Hamidreza Arabiun2
1Postgraduate Dept. of Oral and Maxillofacial Surgery, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.
2Dept. of Oral and Maxillofacial Surgery, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.
چکیده
Statement of the Problem: Extraction of the impacted third molar is often associated with severe postoperative pains, management of which are a big challenge. Lamotrigine is a new antiepileptic drug with pre-emptive analgesic properties, which is hypothesized to alleviate postoperative pain.Purpose: This study aimed to evaluate the efficacy of pre-operative administration of single oral 200 mg lamotrigine in reducing the postoperative pain of impacted third molar surgery.Materials and Method: In this randomized controlled trial, 100 adult patients were divided into two groups (n= 50) to receive either 200 mg oral lamotrigine or placebo 1 hour before the removal of impacted third molar. The patients were monitored for 4 hours in the recovery room and pain intensity was measured through visual analogue scale (VAS) for the next 12 hours at 30-minute intervals. The time and number of rescue analgesics used in 12 hours was also recorded.Results: Two groups were not statistically significantly different regarding the severity of postoperative pain. (p= 0.512)Conclusion: Accordingly, pre-emptive administration of lamotrigine was not effective in diminishing the postoperative acute pain of impacted third molar extraction.Key Words Lamotrigine; Third Molar; Pain Management;  
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