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Zhi, Yue, Gao, Peng, Li, Wei, Zhang, Jie, Gao, Fengling, Zhang, Jichun, Lin, Haitao. (1397). Soluble CD163 Levels and CD163+CD14+ Monocyte/Macrophage Counts in Patients with Asthma. سامانه مدیریت نشریات علمی, 15(3), 239-245. doi: 10.22034/iji.2018.39393
Yue Zhi; Peng Gao; Wei Li; Jie Zhang; Fengling Gao; Jichun Zhang; Haitao Lin. "Soluble CD163 Levels and CD163+CD14+ Monocyte/Macrophage Counts in Patients with Asthma". سامانه مدیریت نشریات علمی, 15, 3, 1397, 239-245. doi: 10.22034/iji.2018.39393
Zhi, Yue, Gao, Peng, Li, Wei, Zhang, Jie, Gao, Fengling, Zhang, Jichun, Lin, Haitao. (1397). 'Soluble CD163 Levels and CD163+CD14+ Monocyte/Macrophage Counts in Patients with Asthma', سامانه مدیریت نشریات علمی, 15(3), pp. 239-245. doi: 10.22034/iji.2018.39393
Zhi, Yue, Gao, Peng, Li, Wei, Zhang, Jie, Gao, Fengling, Zhang, Jichun, Lin, Haitao. Soluble CD163 Levels and CD163+CD14+ Monocyte/Macrophage Counts in Patients with Asthma. سامانه مدیریت نشریات علمی, 1397; 15(3): 239-245. doi: 10.22034/iji.2018.39393

Soluble CD163 Levels and CD163+CD14+ Monocyte/Macrophage Counts in Patients with Asthma

Iranian Journal of Immunology
مقاله 8، دوره 15، شماره 3، آذر 2018، صفحه 239-245    اصل مقاله (214.17 K)
نوع مقاله: Short Paper
شناسه دیجیتال (DOI): 10.22034/iji.2018.39393
نویسندگان
Yue Zhi1، 2؛ Peng Gao3؛ Wei Li3؛ Jie Zhang* 3؛ Fengling Gao2؛ Jichun Zhang2؛ Haitao Lin2
1Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Jilin University,
2Department of Respiratory, Changchun Center Hospital, Changchun, Jilin, China
3Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Jilin University, Changchun, Jilin, China
چکیده
Background: CD163-expressing macrophages are involved in the inflammatory response in asthma. Objective: To assess sputum and serum soluble CD163 (sCD163) and cytokine levels in patients with asthma. Further discussed was the difference between sCD163 and other classic inflammatory mediators. Methods: Sputum was successfully induced in asthma patients (n=85) and healthy controls (n=21). Interleukin (IL)-4, IL-5, IL-1β, IL-8, IL-9, IL-6, and sCD163 levels in sputum were measured. CD163+ monocytes in blood were evaluated using flow cytometry. Results: Sputum sCD163 level significantly increased in asthma (median: 22.4 pg/ml; IQR, 11.52-42.91), unlike healthy controls (10.54 pg/ml;9.85-23.5; P<0.001). Sputum sCD163 (P=0.020) and serum sCD163 (P=0.032) levels were significantly higher in patients with severe asthma compared to those with mild/moderate asthma. Percentage of CD163+ monocytes in patients with asthma was significantly lower than the controls (P<0.001). Conclusion: Increased sCD163 levels in sputum are associated with the impairment of lung function.
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