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Cataño Cañizalez, Yolanda, Uresti Rivera, Edith, Garcia Jacobo, Rocio, Portales Perez, Diana, Bastian, Yadira, Rodriguez Rivera, J, Gonzalez Amaro, Roberto, Enciso Moreno, Jose, Garcia Hernandez, Mariana. (1397). Increased Levels of AIM2 and Circulating Mitochondrial DNA in Type 2 Diabetes. سامانه مدیریت نشریات علمی, 15(2), 142-155. doi: 10.22034/iji.2018.39378
Yolanda Cataño Cañizalez; Edith Uresti Rivera; Rocio Garcia Jacobo; Diana Portales Perez; Yadira Bastian; J Rodriguez Rivera; Roberto Gonzalez Amaro; Jose Enciso Moreno; Mariana Garcia Hernandez. "Increased Levels of AIM2 and Circulating Mitochondrial DNA in Type 2 Diabetes". سامانه مدیریت نشریات علمی, 15, 2, 1397, 142-155. doi: 10.22034/iji.2018.39378
Cataño Cañizalez, Yolanda, Uresti Rivera, Edith, Garcia Jacobo, Rocio, Portales Perez, Diana, Bastian, Yadira, Rodriguez Rivera, J, Gonzalez Amaro, Roberto, Enciso Moreno, Jose, Garcia Hernandez, Mariana. (1397). 'Increased Levels of AIM2 and Circulating Mitochondrial DNA in Type 2 Diabetes', سامانه مدیریت نشریات علمی, 15(2), pp. 142-155. doi: 10.22034/iji.2018.39378
Cataño Cañizalez, Yolanda, Uresti Rivera, Edith, Garcia Jacobo, Rocio, Portales Perez, Diana, Bastian, Yadira, Rodriguez Rivera, J, Gonzalez Amaro, Roberto, Enciso Moreno, Jose, Garcia Hernandez, Mariana. Increased Levels of AIM2 and Circulating Mitochondrial DNA in Type 2 Diabetes. سامانه مدیریت نشریات علمی, 1397; 15(2): 142-155. doi: 10.22034/iji.2018.39378

Increased Levels of AIM2 and Circulating Mitochondrial DNA in Type 2 Diabetes

Iranian Journal of Immunology
مقاله 6، دوره 15، شماره 2، شهریور 2018، صفحه 142-155    اصل مقاله (475.47 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22034/iji.2018.39378
نویسندگان
Yolanda Cataño Cañizalez1؛ Edith Uresti Rivera2؛ Rocio Garcia Jacobo1؛ Diana Portales Perez2؛ Yadira Bastian3؛ J Rodriguez Rivera4؛ Roberto Gonzalez Amaro3؛ Jose Enciso Moreno1؛ Mariana Garcia Hernandez* 1
1Medical Research Unit-Zacatecas, Mexican Institute for Social Security-IMSS, Zacatecas, Mexico
2Research Center for Health Sciences and Biomedicine, UASLP, San Luis Potosí, Mexico
3National Council of Science and Technology (CONACyT), Mexico
4Department of Endocrinology, Hospital Central “Dr. Ignacio Morones Prieto”, San Luis Potosí, Mexico,
چکیده
Background: Chronic inflammation has critical role in Type 2 diabetes (T2D), in which IL-1β contributes in insulin resistance and beta cell dysfunction. The activation of NLRP3 and AIM2 by endogens ligands, such as mtDNA can lead to the release of active form of IL-1β. Objective: To evaluate AIM2 expression and activation as well as circulating mtDNA levels in T2D patients. Methods: AIM2 expression was analyzed by flow cytometry, it’s activity was assessed by measuring in vitro release of IL-1β induced by Poly (dA:dT), and mtDNA copy number was determined by quantitative real-time polymerase chain reaction. Results: Increased percent of AIM2+ cells were detected in monocytes from patients with T2D. Moreover, increased levels of IL-1β in monocytes cultures from T2D patients compared to healthy controls were observed. Also, association between AIM2+ cells and hyperglycemia (r=0.4385, P=0.0095) and triglycerides levels (r=0.5112, P=0.002) and waist-hip ratio (r=0.4710, P=0.0049) were detected. Likewise, the mtDNA copy number was augmented in T2D patients compared to control group. The mtDNA copies number was associated with body mass index (r=0.4231, P=0.0008) and TNF-α levels (r=0.5231, P=0.0005). In addition, increased levels of IL-12p70, TNF-a, IL-10, IL-6, IL-8 and IL-1β were detected in a serum from T2D patients. Conclusion: These results suggest the involvement of AIM2 and mtDNA in the inflammatory process seen in T2D.
کلیدواژه‌ها
AIM2؛ Cell-free mtDNA؛ IL-1β؛ Inflammasome؛ Type 2 Diabetes
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