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Roomandeh, Narges, Saremi, AboTaleb, Arasteh, Javad, Pak, Fatemeh, Mirmohammadkhani, Majid, Kokhaei, Parviz, Zare, Ahad. (1396). Comparing Serum Levels of Th17 and Treg Cytokines in Women with Unexplained Recurrent Spontaneous Abortion and Fertile Women. سامانه مدیریت نشریات علمی, 15(1), 59-67. doi: 10.22034/iji.2018.39341
Narges Roomandeh; AboTaleb Saremi; Javad Arasteh; Fatemeh Pak; Majid Mirmohammadkhani; Parviz Kokhaei; Ahad Zare. "Comparing Serum Levels of Th17 and Treg Cytokines in Women with Unexplained Recurrent Spontaneous Abortion and Fertile Women". سامانه مدیریت نشریات علمی, 15, 1, 1396, 59-67. doi: 10.22034/iji.2018.39341
Roomandeh, Narges, Saremi, AboTaleb, Arasteh, Javad, Pak, Fatemeh, Mirmohammadkhani, Majid, Kokhaei, Parviz, Zare, Ahad. (1396). 'Comparing Serum Levels of Th17 and Treg Cytokines in Women with Unexplained Recurrent Spontaneous Abortion and Fertile Women', سامانه مدیریت نشریات علمی, 15(1), pp. 59-67. doi: 10.22034/iji.2018.39341
Roomandeh, Narges, Saremi, AboTaleb, Arasteh, Javad, Pak, Fatemeh, Mirmohammadkhani, Majid, Kokhaei, Parviz, Zare, Ahad. Comparing Serum Levels of Th17 and Treg Cytokines in Women with Unexplained Recurrent Spontaneous Abortion and Fertile Women. سامانه مدیریت نشریات علمی, 1396; 15(1): 59-67. doi: 10.22034/iji.2018.39341

Comparing Serum Levels of Th17 and Treg Cytokines in Women with Unexplained Recurrent Spontaneous Abortion and Fertile Women

Iranian Journal of Immunology
مقاله 6، دوره 15، شماره 1، خرداد 2018، صفحه 59-67    اصل مقاله (281.14 K)
نوع مقاله: Short Paper
شناسه دیجیتال (DOI): 10.22034/iji.2018.39341
نویسندگان
Narges Roomandeh1، 2؛ AboTaleb Saremi2؛ Javad Arasteh3؛ Fatemeh Pak4؛ Majid Mirmohammadkhani5؛ Parviz Kokhaei* 6، 7؛ Ahad Zare* 2
1Student Research Committee and Department of Immunology, Faculty of Medicine, Semnan University of Medical Sciences, Semnan,
2Sarem Fertility and Infertility Research Center (SAFIR) and Sarem Cell Research Center (SCRC), Sarem Women’s Hospital, Tehran, Iran
3Department of Biology, Faculty of Basic Sciences, Islamic Azad University Central Tehran Branch, Tehran,
4Cancer Research Center and Department of Immunology, Faculty of Medicine, Semnan University of Medical Sciences, Semnan, Iran,
5Research Center for Social Determinants of Health, Semnan University of Medical Sciences, Semnan, Iran
6Cancer Research Center and Department of Immunology, Faculty of Medicine
7Immune and Gene Therapy Lab, Cancer Centre Karolinska, Karolinska University Hospital, Stockholm, Sweden
چکیده
Background: Increased evidences have shown that unexplained recurrent spontaneous abortion (URSA) is associated with inflammatory responses and breakage of immunological autotolerance. Therefore, the balance between Th17 and Treg cells may elucidate the pathophysiology of URSA. Objective: To investigate the serum concentration of regulatory and inflammatory cytokines associated with Treg and Th17 in both normal and URSA females. Methods: Forty-six women with URSA and 28 non-pregnant control women with at least one successful pregnancy were included. Serum was obtained from both groups and stored at -70°C. The serum concentrations of IL-17, IL-21, IL-22, IL-10, and TGF-β were quantitatively determined by ELISA. Results: The levels of IL-17, IL-21, and IL-22 in sera were significantly higher (P<0.001, P=0.01 and P<0.001, respectively) and TGF-β serum concentration was significantly lower (P=0.02) in URSA women compared with normal controls. Conclusion: Our results suggest that enhancement in Th17-associated cytokine levels and reduction in TGF-β may be one of the factors involved in URSA.
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