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Sohrabi, Maryam, Alahgholi-Hajibehzad, Mahdi, Gholami Mahmoodian, Zahra, Hosseini Siyar, Sayed Ali, Zamani, Alireza. (1396). Effect of Cinnamon and Turmeric Aqueous Extracts on Serum Interleukin-17F Level of High Fructose-Fed Rats. سامانه مدیریت نشریات علمی, 15(1), 38-46. doi: 10.22034/iji.2018.39339
Maryam Sohrabi; Mahdi Alahgholi-Hajibehzad; Zahra Gholami Mahmoodian; Sayed Ali Hosseini Siyar; Alireza Zamani. "Effect of Cinnamon and Turmeric Aqueous Extracts on Serum Interleukin-17F Level of High Fructose-Fed Rats". سامانه مدیریت نشریات علمی, 15, 1, 1396, 38-46. doi: 10.22034/iji.2018.39339
Sohrabi, Maryam, Alahgholi-Hajibehzad, Mahdi, Gholami Mahmoodian, Zahra, Hosseini Siyar, Sayed Ali, Zamani, Alireza. (1396). 'Effect of Cinnamon and Turmeric Aqueous Extracts on Serum Interleukin-17F Level of High Fructose-Fed Rats', سامانه مدیریت نشریات علمی, 15(1), pp. 38-46. doi: 10.22034/iji.2018.39339
Sohrabi, Maryam, Alahgholi-Hajibehzad, Mahdi, Gholami Mahmoodian, Zahra, Hosseini Siyar, Sayed Ali, Zamani, Alireza. Effect of Cinnamon and Turmeric Aqueous Extracts on Serum Interleukin-17F Level of High Fructose-Fed Rats. سامانه مدیریت نشریات علمی, 1396; 15(1): 38-46. doi: 10.22034/iji.2018.39339

Effect of Cinnamon and Turmeric Aqueous Extracts on Serum Interleukin-17F Level of High Fructose-Fed Rats

Iranian Journal of Immunology
مقاله 4، دوره 15، شماره 1، خرداد 2018، صفحه 38-46    اصل مقاله (154.6 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22034/iji.2018.39339
نویسندگان
Maryam Sohrabi1؛ Mahdi Alahgholi-Hajibehzad2، 3؛ Zahra Gholami Mahmoodian1؛ Sayed Ali Hosseini Siyar4؛ Alireza Zamani* 2، 3
1Department of Anatomy, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
2Department of Immunology, School of Medicine,
3Molecular Immunology Research Group, Research Center for Molecular Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
4Department of Animal Science, Agriculture Faculty, Bu-Ali Sina University, Hamadan, Iran
چکیده
 
Background: Studies have indicated that extraweight and obesity induce chronic inflammation, which can lead to other diseases such as cancers. Objective: To evaluate the effects of two weight-lowering and anti-inflammatory agents including cinnamon, and turmeric, on serum levels of interleukin-17 (IL-17) as a pro-inflammatory cytokine. Methods: In this study, 64 rats were designated in eight groups. The control group received normal diet. The other groups were fed with normal diet plus high cinnamon (3 mg/ml), high turmeric (3 mg/ml), high-fructose solution (30%), fructose solution with low (0.15 mg/ml) and high doses (3 mg/ml) of cinnamon and turmeric three times per week. The serum level of IL-17F was measured by enzyme-linked immunosorbent assay (ELISA). Results: High fructose consumption led to an increase in the weight and serum level of IL-17. While, feeding with cinnamon and turmeric caused to decline weight but, surprisingly increased IL-17F levels. Conclusion: Although, some studies have showed that cinnamon and turmeric supplementation decreased IL-17F under the standard diet, in the presence of high fructose diet and extraweight their effects were reversed and caused an increase in serum level of IL-17F.
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