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Lavu, Vamsi, Venkatesan, Vettriselvi, Venugopal, Priyanka, Lakkakula, Bhaskar Venkata Kameswara Subrahmanya, Paul, Solomon Franklin Durairaj, Peria, Kumarasamy, Rao, Suresh Ranga. (1395). Clinical Relevance of Cytokines Gene Polymorphisms and Protein Levels in Gingival Cervical Fluid from Chronic Periodontitis Patients. سامانه مدیریت نشریات علمی, 14(1), 51-58. doi: 10.22034/iji.2017.39288
Vamsi Lavu; Vettriselvi Venkatesan; Priyanka Venugopal; Bhaskar Venkata Kameswara Subrahmanya Lakkakula; Solomon Franklin Durairaj Paul; Kumarasamy Peria; Suresh Ranga Rao. "Clinical Relevance of Cytokines Gene Polymorphisms and Protein Levels in Gingival Cervical Fluid from Chronic Periodontitis Patients". سامانه مدیریت نشریات علمی, 14, 1, 1395, 51-58. doi: 10.22034/iji.2017.39288
Lavu, Vamsi, Venkatesan, Vettriselvi, Venugopal, Priyanka, Lakkakula, Bhaskar Venkata Kameswara Subrahmanya, Paul, Solomon Franklin Durairaj, Peria, Kumarasamy, Rao, Suresh Ranga. (1395). 'Clinical Relevance of Cytokines Gene Polymorphisms and Protein Levels in Gingival Cervical Fluid from Chronic Periodontitis Patients', سامانه مدیریت نشریات علمی, 14(1), pp. 51-58. doi: 10.22034/iji.2017.39288
Lavu, Vamsi, Venkatesan, Vettriselvi, Venugopal, Priyanka, Lakkakula, Bhaskar Venkata Kameswara Subrahmanya, Paul, Solomon Franklin Durairaj, Peria, Kumarasamy, Rao, Suresh Ranga. Clinical Relevance of Cytokines Gene Polymorphisms and Protein Levels in Gingival Cervical Fluid from Chronic Periodontitis Patients. سامانه مدیریت نشریات علمی, 1395; 14(1): 51-58. doi: 10.22034/iji.2017.39288

Clinical Relevance of Cytokines Gene Polymorphisms and Protein Levels in Gingival Cervical Fluid from Chronic Periodontitis Patients

Iranian Journal of Immunology
مقاله 5، دوره 14، شماره 1، خرداد 2017، صفحه 51-58    اصل مقاله (258.41 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22034/iji.2017.39288
نویسندگان
Vamsi Lavu1؛ Vettriselvi Venkatesan2؛ Priyanka Venugopal2؛ Bhaskar Venkata Kameswara Subrahmanya Lakkakula3؛ Solomon Franklin Durairaj Paul2؛ Kumarasamy Peria4؛ Suresh Ranga Rao* 1
1Department of Periodontics, Faculty of Dental Sciences, Sri Ramachandra University, Chennai, India
2Department of Human Genetics, College of Biomedical Sciences, Sri Ramachandra University, Chennai, Tamil Nadu, India
3Department of Medical Genetics, Sickle Cell Institute Chhattisgarh, Raipur, Chhattisgarh, Iran
4Tamil Nadu Veterinary and Agricultural Sciences University, Tami Nadu, India
چکیده
Background: Cytokines are suggested to play a role in periodontitis. Objective: To determine and compare the levels of Interleukin-1 beta (IL-1β) and Tumor necrosis factor alpha (TNF-α) in gingival crevicular fluid (GCF) samples amongst healthy individuals and  those with chronic periodontitis. Further to compare the GCF cytokine levels in three genotype classes defined by the respective gene polymorphisms. Methods: The study was conducted on 41 chronic periodontitis patients and 40 healthy volunteers. IL-1β and TNF-α were quantified in GCF by cytometric bead array. DNA was extracted from peripheral blood samples and genotyping of IL1B +3954C/T (rs1143634) IL1B -511G/A (rs16944), TNFA -1031T/C (rs1799964) and TNFA -863C/A (rs1800630) polymorphisms were performed using Sanger sequencing and Taqman SNP genotyping assays methods. Results: Both IL-1β and TNF-α levels were significantly higher in chronic periodontitis group compared to the controls. IL-1β and TNF-α levels did not significantly differ in genotype classes of the respective polymorphism (IL1B -511G/A, TNFA -1031T/C and TNFA -863C/A). However, individuals with CT genotype of IL1B +3954C/T showed higher levels of IL-1β in the gingival crevicular fluid (ANOVA p<0.05). Conclusion: The results of this study revealed the presence of higher levels of IL-1β and TNF-α in subjects with periodontitis and genetic control of IL-1β levels in our samples of Indians. 
کلیدواژه‌ها
Gene؛ Gingival Crevicular Fluid؛ Interleukin-1 beta؛ Polymorphism؛ Allele؛ Tumor Necrosis Factor- alpha
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