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Mansouri, Reza, Akbari, Firoozeh, Vodjgani, Mohammad, Mahboudi, Fereidoun, Kalantar, Fathollah, Mirahmadian, Mahroo. (1386). Serum Cytokines Profiles in Iranian Patients with Preeclampsia. سامانه مدیریت نشریات علمی, 4(3), 179-185. doi: 10.22034/iji.2007.17196
Reza Mansouri; Firoozeh Akbari; Mohammad Vodjgani; Fereidoun Mahboudi; Fathollah Kalantar; Mahroo Mirahmadian. "Serum Cytokines Profiles in Iranian Patients with Preeclampsia". سامانه مدیریت نشریات علمی, 4, 3, 1386, 179-185. doi: 10.22034/iji.2007.17196
Mansouri, Reza, Akbari, Firoozeh, Vodjgani, Mohammad, Mahboudi, Fereidoun, Kalantar, Fathollah, Mirahmadian, Mahroo. (1386). 'Serum Cytokines Profiles in Iranian Patients with Preeclampsia', سامانه مدیریت نشریات علمی, 4(3), pp. 179-185. doi: 10.22034/iji.2007.17196
Mansouri, Reza, Akbari, Firoozeh, Vodjgani, Mohammad, Mahboudi, Fereidoun, Kalantar, Fathollah, Mirahmadian, Mahroo. Serum Cytokines Profiles in Iranian Patients with Preeclampsia. سامانه مدیریت نشریات علمی, 1386; 4(3): 179-185. doi: 10.22034/iji.2007.17196

Serum Cytokines Profiles in Iranian Patients with Preeclampsia

Iranian Journal of Immunology
مقاله 7، دوره 4، شماره 3، اسفند 2007، صفحه 179-185    اصل مقاله (154.02 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22034/iji.2007.17196
نویسندگان
Reza Mansouri1؛ Firoozeh Akbari2؛ Mohammad Vodjgani1؛ Fereidoun Mahboudi3؛ Fathollah Kalantar1؛ Mahroo Mirahmadian* 1
1Department of Immunology, School of Medicine, Medical sciences / University of Tehran
2Department of Obstetrics and Gynaecology, School of Medicine, Medical sciences / University of Tehran
3Biotechnology Research Center, Pasteur Institute of Iran, Tehran Iran
چکیده
Background: Preeclampsia is a major cause of mortality and morbidity and is also a leading cause of preterm birth and intrauterine growth retardation. Several studies have reported abnormal levels of cytokines in women with preeclampsia.
Objectives: To detect serum levels of various cytokines in pregnant women with and without preeclampsia in the third trimester of pregnancy.
Methods: Thirty patients with preeclampsia and thirty normal pregnant women were enrolled in the study. Blood samples were taken and serum levels of IFN γ, IL-12p70, IL-18, IL-15, IL-4 and IL-10 were measured by enzyme-linked immunosorbent assay (ELISA).
Results: Preeclamptic women had significantly increased levels of circulating IL-12p70 (p < 0.05), IL-18 (p < 0.001), IL-4 (p < 0.001), IL-15 (p < 0.05) and IFN γ (p < 0.001). By contrast, circulating levels of IL-10 were not significantly different between the two groups.
Conclusions: The present study supports the hypothesis of altered immune response in preeclampsia and suggests that dysregulation of cytokine expression occurs in preeclampsia with increased levels of IFN γ, IL-12p70, IL-15, IL-18 and IL-4.
کلیدواژه‌ها
Preeclampsia؛ Cytokines؛ ELISA
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