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Memarian, Ali, Jeddi Tehrani, Mahmood, Vossough, Parvaneh, Sharifian, Ramazan Ali, Rabbani, Hodjatallah, Shokri, Fazel. (1386). Expression Profile of Wnt Molecules in Leukemic Cells from Iranian Patients with Acute Myeloblastic Leukemia. سامانه مدیریت نشریات علمی, 4(3), 145-154. doi: 10.22034/iji.2007.17191
Ali Memarian; Mahmood Jeddi Tehrani; Parvaneh Vossough; Ramazan Ali Sharifian; Hodjatallah Rabbani; Fazel Shokri. "Expression Profile of Wnt Molecules in Leukemic Cells from Iranian Patients with Acute Myeloblastic Leukemia". سامانه مدیریت نشریات علمی, 4, 3, 1386, 145-154. doi: 10.22034/iji.2007.17191
Memarian, Ali, Jeddi Tehrani, Mahmood, Vossough, Parvaneh, Sharifian, Ramazan Ali, Rabbani, Hodjatallah, Shokri, Fazel. (1386). 'Expression Profile of Wnt Molecules in Leukemic Cells from Iranian Patients with Acute Myeloblastic Leukemia', سامانه مدیریت نشریات علمی, 4(3), pp. 145-154. doi: 10.22034/iji.2007.17191
Memarian, Ali, Jeddi Tehrani, Mahmood, Vossough, Parvaneh, Sharifian, Ramazan Ali, Rabbani, Hodjatallah, Shokri, Fazel. Expression Profile of Wnt Molecules in Leukemic Cells from Iranian Patients with Acute Myeloblastic Leukemia. سامانه مدیریت نشریات علمی, 1386; 4(3): 145-154. doi: 10.22034/iji.2007.17191

Expression Profile of Wnt Molecules in Leukemic Cells from Iranian Patients with Acute Myeloblastic Leukemia

Iranian Journal of Immunology
مقاله 2، دوره 4، شماره 3، اسفند 2007، صفحه 145-154    اصل مقاله (248.43 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22034/iji.2007.17191
نویسندگان
Ali Memarian1؛ Mahmood Jeddi Tehrani2، 3؛ Parvaneh Vossough4؛ Ramazan Ali Sharifian5؛ Hodjatallah Rabbani3، 6؛ Fazel Shokri* 1، 7
1Department of Immunology, School of Public Health, Medical Sciences / University of Tehran
2Monoclonal Antibody Research Center, Avesina Research Institute, Tehran, Iran
3Immune and Gene Therapy Lab, Cancer Center Karolinska, Karolinska Hospital, Stockholm, Sweden
4Clinic of Hematology, Ali-Asghar Hospital, Faculty of Medicine, Iran University of Medical Sciences
5Clinic of Hematology and Oncology, Vali-Asr Hospital, Faculty of Medicine, Medical Sciences / University of Tehran
6Nanobiotechnology Research Center, Avesina Research Institute
7National Cell Bank of Iran, Pasteur Institute of Iran, Tehran, Iran
چکیده
Background: Wnt molecules play a key role in growth, proliferation and development of some embryonic and adult organs as well as hematopoietic stem cells. Wnt signaling pathways are aberrantly activated in many tumor types, including solid tumors and hematologic malignancies.
Objective: To investigate the expression profile of a large number of Wnt genes in leukemic cells from Iranian patients with acute myeloblastic leukemia.
Methods: RT-PCR method was used to determine the Wnt genes expression in bone marrow (BM) and/or peripheral blood (PB) samples from 16 patients with AML and PB samples of 36 normal subjects.
Results: Among 14 Wnt molecules included in this study, Wnt-7A and Wnt-10A were significantly down-regulated (p = 0.002 and p < 0.0001, respectively) and Wnt-3 was significantly over-expressed (p < 0.02) in AML patients compared to normal subjects. No significant association was found between Wnt expression and FAB classification of the patients.
Conclusion: Our results demonstrated for the first time aberrant expression of Wnt-7A, Wnt-10A and Wnt-3 genes in Iranian AML patients. This may be of relevance to the tumorigenesis process in this malignancy.
کلیدواژه‌ها
Wnt؛ β-catenin؛ Acute Myeloblastic Leukemia؛ RT-PCR
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