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Rastin, Maryam, Hatef, Mohammad Reza, Tabasi, Nafise, Sheikh, Akram, Abbasi, Javid Morad, Mahmoudi, Mahmoud. (1386). Sex Hormones and Peripheral White Blood Cell Subsets in Systemic Lupus Erythematosus Patients. سامانه مدیریت نشریات علمی, 4(2), 110-115. doi: 10.22034/iji.2007.17187
Maryam Rastin; Mohammad Reza Hatef; Nafise Tabasi; Akram Sheikh; Javid Morad Abbasi; Mahmoud Mahmoudi. "Sex Hormones and Peripheral White Blood Cell Subsets in Systemic Lupus Erythematosus Patients". سامانه مدیریت نشریات علمی, 4, 2, 1386, 110-115. doi: 10.22034/iji.2007.17187
Rastin, Maryam, Hatef, Mohammad Reza, Tabasi, Nafise, Sheikh, Akram, Abbasi, Javid Morad, Mahmoudi, Mahmoud. (1386). 'Sex Hormones and Peripheral White Blood Cell Subsets in Systemic Lupus Erythematosus Patients', سامانه مدیریت نشریات علمی, 4(2), pp. 110-115. doi: 10.22034/iji.2007.17187
Rastin, Maryam, Hatef, Mohammad Reza, Tabasi, Nafise, Sheikh, Akram, Abbasi, Javid Morad, Mahmoudi, Mahmoud. Sex Hormones and Peripheral White Blood Cell Subsets in Systemic Lupus Erythematosus Patients. سامانه مدیریت نشریات علمی, 1386; 4(2): 110-115. doi: 10.22034/iji.2007.17187

Sex Hormones and Peripheral White Blood Cell Subsets in Systemic Lupus Erythematosus Patients

Iranian Journal of Immunology
مقاله 6، دوره 4، شماره 2، شهریور 2007، صفحه 110-115    اصل مقاله (147.91 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22034/iji.2007.17187
نویسندگان
Maryam Rastin1؛ Mohammad Reza Hatef2؛ Nafise Tabasi1؛ Akram Sheikh1؛ Javid Morad Abbasi1؛ Mahmoud Mahmoudi* 1
1Immunology Research Center, BuAli Research Institute, Medical School, Mashhad University of Medical Sciences, Mashhad, Iran
2Rheumatology Section, Emam Reza Hospital, Medical School, Mashhad University of Medical Sciences, Mashhad, Iran
چکیده
Background: Systemic Lupus Eyrythematosus (SLE) is an autoimmune disease charac-terized by antibodies to nuclear antigens, particularly anti-dsDNA. Imbalance between production and destruction of immune cells causes cytopenia. Sex hormones have im-munomodulatory effects; estrogen increases the production of autoantibodies in SLE prone NZB/NZW mice.
Objective: To investigate the relationship between sex hor-mones, anti-dsDNA, and lymphocyte subsets in Iranian patients with SLE.
Methods: 38 SLE patients (28 females and 10 males) meeting 4 of 11 ACR revised criteria for SLE classification, and 20 age and sex matched healthy individuals (10 females and 10 males) participated in this study. Lymphocyte subsets were analyzed using flow cy-tometric analysis. Serum anti-dsDNA levels and sex hormones concentrations were de-termined using commercial ELISA and RIA kits, respectively.
Results: The absolute count of white blood cells, lymphocytes, T lymphocytes (CD3+), T helper cells (CD3+CD4+), B cells (CD19+) and Nk cells (CD3- CD16+CD56+) in SLE patients di-minished significantly in comparison to control group (p<0.05). IgG anti-dsDNA anti-body levels were significantly higher in patients compared to controls as expected (p<0.05). Prolactin increased significantly, while DHEAS showed a significant decrease in SLE patients compared with the controls (p<0.05), however the level of estrogen did not have any significant difference in SLE patients in comparison to controls.
Conclusion: Increased concentration of prolactin together with a simultaneous decrease in serum DHEAS in SLE patients are associated with anti-dsDNA elevation and a decrease in almost all lymphocyte subsets.
کلیدواژه‌ها
SLE؛ Anti-dsDNA؛ Estrogen؛ Progestrone؛ Prolactin؛ DHEAS
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