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Matloubi, Hedieh, Vodjgani, Mohammad, Nasehi, Abbass Ali, Niknam, Mohammad Hossein, Kazemnejad, Anoushirvan, Salehi, Eisa, Aboufazeli, Tahereh, Gheflati, Zahra. (1385). Decreased T Cell Response to Mitogen and Increased Anti-cytoplasmic Antibody in Drug-Free Schizophrenic Patients. سامانه مدیریت نشریات علمی, 4(1), 32-37. doi: 10.22034/iji.2007.17177
Hedieh Matloubi; Mohammad Vodjgani; Abbass Ali Nasehi; Mohammad Hossein Niknam; Anoushirvan Kazemnejad; Eisa Salehi; Tahereh Aboufazeli; Zahra Gheflati. "Decreased T Cell Response to Mitogen and Increased Anti-cytoplasmic Antibody in Drug-Free Schizophrenic Patients". سامانه مدیریت نشریات علمی, 4, 1, 1385, 32-37. doi: 10.22034/iji.2007.17177
Matloubi, Hedieh, Vodjgani, Mohammad, Nasehi, Abbass Ali, Niknam, Mohammad Hossein, Kazemnejad, Anoushirvan, Salehi, Eisa, Aboufazeli, Tahereh, Gheflati, Zahra. (1385). 'Decreased T Cell Response to Mitogen and Increased Anti-cytoplasmic Antibody in Drug-Free Schizophrenic Patients', سامانه مدیریت نشریات علمی, 4(1), pp. 32-37. doi: 10.22034/iji.2007.17177
Matloubi, Hedieh, Vodjgani, Mohammad, Nasehi, Abbass Ali, Niknam, Mohammad Hossein, Kazemnejad, Anoushirvan, Salehi, Eisa, Aboufazeli, Tahereh, Gheflati, Zahra. Decreased T Cell Response to Mitogen and Increased Anti-cytoplasmic Antibody in Drug-Free Schizophrenic Patients. سامانه مدیریت نشریات علمی, 1385; 4(1): 32-37. doi: 10.22034/iji.2007.17177

Decreased T Cell Response to Mitogen and Increased Anti-cytoplasmic Antibody in Drug-Free Schizophrenic Patients

Iranian Journal of Immunology
مقاله 4، دوره 4، شماره 1، خرداد 2007، صفحه 32-37    اصل مقاله (68.19 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22034/iji.2007.17177
نویسندگان
Hedieh Matloubi1؛ Mohammad Vodjgani* 1؛ Abbass Ali Nasehi2؛ Mohammad Hossein Niknam1؛ Anoushirvan Kazemnejad3؛ Eisa Salehi1؛ Tahereh Aboufazeli1؛ Zahra Gheflati1
1Department of Immunology, Faculty of Medicine, Medical Sciences/University of Tehran
2Iran-Helal Institute of Applied Science and Technology
3Department of Statistics, Tarbiat Modarress University, Tehran, Iran
چکیده
Background: Apart from genetic and environmental factors, activation of autoreactive mechanisms has been proposed to play a role in the pathogenesis of schizophrenia. In re-cent years, considerable work has been carried out to understand the role and contribution of the immune system in this disease.
Objective: To investigate the T cell response to phytohaemagglutinin (PHA) and determine the serum levels of anti-nuclear antibody (ANA), anti-cytoplasmic antibody (ACA), and circulating immune complexes (CIC) in schizophrenic patients.
Methods: A total of 30 drug-free schizophrenic patients and 42 healthy controls were enrolled in this study. T cell proliferation in response to PHA was measured using Methyl Thiazol Tetrazolium test. ANA and ACA were measured by indi-rect immunofluorescence. CIC concentration was determined using poly ethylene glycol precipitation assay.
Results: Mean PHA response was 1.96 ± 0.83 in patients and 3.72±1.39 in healthy controls (p < 0.001). ANA and CIC concentrations were not signifi-cantly different between two groups. In addition, ACA was detected only in patients.
Conclusion: Increased production of ACA together with lower T cell response to mito-gens in our patients provides evidence for the involvement of autoimmune mechanisms in the pathogenesis of schizophrenia.
کلیدواژه‌ها
Schizophrenia؛ T Cell Proliferation؛ ANA؛ ACA؛ CIC
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