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Comparison of the Salivary Immu-noglobulin Concentration Levels between Children with Early Childhood Caries and Caries-Free Children | ||
| Iranian Journal of Immunology | ||
| مقاله 5، دوره 5، شماره 4، اسفند 2008، صفحه 217-221 اصل مقاله (89.16 K) | ||
| نوع مقاله: Original Article | ||
| شناسه دیجیتال (DOI): 10.22034/iji.2008.17171 | ||
| نویسندگان | ||
| Ali Bagherian1؛ Abdullah Jafarzadeh2؛ Mohsen Rezaeian3؛ Shima Ahmadi1؛ Mohammad Taghi Rezaity2 | ||
| 1Department of Pediatric Dentistry, Dental School | ||
| 2Department of Immunology | ||
| 3Department of Epidemiology, Medical School, Rafsanjan University of Medical Sciences, Rafsanjan, Iran | ||
| چکیده | ||
| Background: Early Childhood Caries (ECC) is one of the most common chronic child-hood diseases. In spite of the global decrease in dental caries in the past decades, ECC has become a significant problem in many developing countries and also in a few indus-trialized nations. Saliva as a host factor can play an important role in the process of den-tal caries. Objective: The aim of this study was to compare sIgA and IgG as saliva components between ECC and caries-free groups. Methods: In this cross-sectional study, samples of unstimulated saliva of 90 children (45 in ECC group & 45 in caries-free group) were taken with Scully method. Then the concentration levels of sIgA and IgG were measured with Enzyme Linked Immunosorbent Assay and Single Radial Im-munodiffusion methods. Results: Mean concentration levels of salivary sIgA and IgG were significantly higher among children with ECC (p<0.05). There was also a weak inverse correlation between sIgA level and DMFT index in ECC group but it was not statistically significant (p=0.056). Conclusion: The high concentration of salivary im-munoglobulin in children with ECC may be associated with an increased antigenic load, leading to high production of antibodies. | ||
| کلیدواژهها | ||
| dental caries؛ immunoglobulins؛ Saliva | ||
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