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Omrani, Mir Davood, Mokhtari, Mohammad Reza, Tagizadae, Ali, Bagheri, Morteza, Ahmad-Poor, Pedram. (1387). Association of CCR5-59029 A/G and CCR2-V64I Variants with Renal Allograft Survival. سامانه مدیریت نشریات علمی, 5(4), 201-206. doi: 10.22034/iji.2008.17168
Mir Davood Omrani; Mohammad Reza Mokhtari; Ali Tagizadae; Morteza Bagheri; Pedram Ahmad-Poor. "Association of CCR5-59029 A/G and CCR2-V64I Variants with Renal Allograft Survival". سامانه مدیریت نشریات علمی, 5, 4, 1387, 201-206. doi: 10.22034/iji.2008.17168
Omrani, Mir Davood, Mokhtari, Mohammad Reza, Tagizadae, Ali, Bagheri, Morteza, Ahmad-Poor, Pedram. (1387). 'Association of CCR5-59029 A/G and CCR2-V64I Variants with Renal Allograft Survival', سامانه مدیریت نشریات علمی, 5(4), pp. 201-206. doi: 10.22034/iji.2008.17168
Omrani, Mir Davood, Mokhtari, Mohammad Reza, Tagizadae, Ali, Bagheri, Morteza, Ahmad-Poor, Pedram. Association of CCR5-59029 A/G and CCR2-V64I Variants with Renal Allograft Survival. سامانه مدیریت نشریات علمی, 1387; 5(4): 201-206. doi: 10.22034/iji.2008.17168

Association of CCR5-59029 A/G and CCR2-V64I Variants with Renal Allograft Survival

Iranian Journal of Immunology
مقاله 2، دوره 5، شماره 4، اسفند 2008، صفحه 201-206    اصل مقاله (241.93 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22034/iji.2008.17168
نویسندگان
Mir Davood Omrani* 1؛ Mohammad Reza Mokhtari2؛ Ali Tagizadae2؛ Morteza Bagheri1؛ Pedram Ahmad-Poor2
1Department of Genetics
2Department of Urology and Nephrology, Uromia University of Medical Science, Uromia, Iran
چکیده
Background: Despite advances in the medical care of renal transplant recipients which have led to an improvement in allograft survival, renal allograft rejection is still a major ob-stacle to successful organ transplantation. Understanding the mechanisms contributing to allograft rejection will be of great importance for the development of efficient antirejection strategies.
Objective: The aim of current investigation was to study the impact of polymor-phisms of CCR5Δ32, CCR5- 59029 A/G and CCR2-V64I on renal allograft survival.
Methods: Using PCR and PCR-RFLP methods in 84 renal transplant recipients, the influ-ence of CCR5Δ32, CCR5- 59029 A/G and CCR2-V64I polymorphisms on renal allograft survival in two rejector and non-rejector groups were examined. Rejector group was de-fined as having rejection before 1 year and non-rejector group had stable graft function at least for 5 years.
Results: Significant reductions were found in the risk of renal transplant rejection in recipients possessing the CCR2-64I (A) allele (p=0.03) or 59029-A allele (p=0.03) compared to non-rejector group. There were no significant differences in the fre-quency of CCR5Δ32 polymorphism in rejector group compared to non-rejector group (p>0.05).
Conclusion: It was possible to conclude that the chemokine receptors CCR2-V64I (A) and CCR5- 59029 A alleles may influence renal allograft survival.
کلیدواژه‌ها
Chemokine Receptors؛ Genetic Polymorphism؛ Genotyping؛ Graft Re-jections؛ Graft Survival؛ renal transplantation
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