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Jahadi Hosseini, Hamid Reza, Kamali Sarvestani, Eskanadar, Akbari, Mitra, Mosallaei, Mahnaz. (1387). Effect of Fas -670 A/G Gene Polymorphism on Corneal Allograft Endothelial Rejection. سامانه مدیریت نشریات علمی, 6(1), 28-32. doi: 10.22034/iji.2009.17070
Hamid Reza Jahadi Hosseini; Eskanadar Kamali Sarvestani; Mitra Akbari; Mahnaz Mosallaei. "Effect of Fas -670 A/G Gene Polymorphism on Corneal Allograft Endothelial Rejection". سامانه مدیریت نشریات علمی, 6, 1, 1387, 28-32. doi: 10.22034/iji.2009.17070
Jahadi Hosseini, Hamid Reza, Kamali Sarvestani, Eskanadar, Akbari, Mitra, Mosallaei, Mahnaz. (1387). 'Effect of Fas -670 A/G Gene Polymorphism on Corneal Allograft Endothelial Rejection', سامانه مدیریت نشریات علمی, 6(1), pp. 28-32. doi: 10.22034/iji.2009.17070
Jahadi Hosseini, Hamid Reza, Kamali Sarvestani, Eskanadar, Akbari, Mitra, Mosallaei, Mahnaz. Effect of Fas -670 A/G Gene Polymorphism on Corneal Allograft Endothelial Rejection. سامانه مدیریت نشریات علمی, 1387; 6(1): 28-32. doi: 10.22034/iji.2009.17070

Effect of Fas -670 A/G Gene Polymorphism on Corneal Allograft Endothelial Rejection

Iranian Journal of Immunology
مقاله 4، دوره 6، شماره 1، خرداد 2009، صفحه 28-32    اصل مقاله (224.72 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22034/iji.2009.17070
نویسندگان
Hamid Reza Jahadi Hosseini* 1، 2؛ Eskanadar Kamali Sarvestani3؛ Mitra Akbari1، 2؛ Mahnaz Mosallaei1، 2
1Department of Ophthalmology
2Poostchi Eye Research Center, Autoimmune Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
3Department of Immunology
چکیده
Background: Human cornea expresses functional Fas-ligand capable of killing Fas+ activated lymphocytes. Fas expression is partly regulated by -670 A/G polymorphism in the promoter region of Fas gene.
Objective: The aim of the present study is to determine the association between Fas-670A/G polymorphism and survival of corneal transplantation.
Methods: In 276 graft recipients who mainly underwent penetrating keratoplasty because of keratoconus, bullous keratopathy and corneal opacity, Fas -670 A/G polymorphism was determined by allele specific oligonucleotide polymerase chain reaction (ASO-PCR) techniques.
Results: There was no statistically significant relationship between Fas -670 A/G polymorphism and rejection episode (p=0.35). Moreover, the relationship between this polymorphism and rejection episode outcome (transplant recovery vs failure) was not statistically significant (p=0.13).
Conclusion: The results of the present study show no significant correlation between corneal graft rejection, rejection recovery and Fas -670A/G gene polymorphism.
کلیدواژه‌ها
Corneal Transplantation؛ Fas Ligand؛ Rejection
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